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Study of Cannabinoid Receptor Agonist in Asthma Therapy

Research Project

Project/Area Number 18591202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionDokkyo Medical University

Principal Investigator

SHIGEMI Yoshihara  Dokkyo Medical University, Pediatrics, Associate Professor (80220713)

Co-Investigator(Kenkyū-buntansha) ABE Toshio  Dokkyo Medical University, Pediatrics, Research Associate (40221048)
YAMADA Yumi  Dokkyo Medical University, Pediatrics, Research Associate (00306200)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥1,810,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
KeywordsCannabinoid agonist / WIN55212-2 / guinea pig / airway inflammation / asthma / neurosenic inflammation / therapy / WIN 55212-2
Research Abstract

We investigated that Cannabinoid receptor agonist (WIN55212-2) inhibits antigen-induced plasma extravasation by in guinea pig airways. Plasma extravasation was assessed by the photometric measurement of the extravasated Evans blue after formamide extravasation. In sensitized guinea pigs pretreated with phosphoramidon, WIN55212-2 (0.1 mg/kg iv) significant/7 inhibited plasma extravasation evoked by ovalbumin aerosol (5%, 2min) by 87.2% in the trachea and 66.5% in the main bronchi. Pretreated with WIN55212-2 (0.1, 0.01 and 0.001mg/kg iv) dose-dependentry reduced antigen-induced plasma extravasation in the sensitized guinea pig trachea and main bronchi. A cannabinoid CB2 receptor antagonist, SR144528, reduced the inhibitory effects of WIN55212-2, but not a cannabinoid CB1 receptor antagonist, SR141716A. These findings suggest that WIN55212-2 inhibits the activation of C-fibers via cannabinoid CB2 receptors and reduced airway neurogenic inflammatory reactions in vivo.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (12 results)

All 2007 2006

All Journal Article (10 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] 気管支喘息と神ペプチド2007

    • Author(s)
      阿部 利夫、吉原 重美
    • Journal Title

      アレルギー、免疫 14

      Pages: 878-883

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Asthma and Neuropeptide(in Japanese)2007

    • Author(s)
      Abe T, Yoshihara, S
    • Journal Title

      Medical Journal, Allergology and Inmunology 14

      Pages: 878-883

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma2007

    • Author(s)
      Hatsushika K, Yoshihara S, et. al.
    • Journal Title

      Clin Exp Allergy 37

      Pages: 1165-1174

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下気道の神経原性炎症におけるバニロイド受容体の役割2007

    • Author(s)
      吉原 重美
    • Journal Title

      アレルギーと神経ペプチド 3

      Pages: 18-18

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 抗原誘発気道血漿漏出反応に対するカンナビノイド合成アゴニスト(WIN55212-2)の抑制効果2007

    • Author(s)
      福田 啓伸、吉原 重美
    • Journal Title

      日本アレルギー学会誌 56

      Pages: 1141-1141

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Cannabinoid receptor agonists inhibit Ca^<2+> influx to synaptosomes from rat brain2006

    • Author(s)
      Yoshihara S, et. al.
    • Journal Title

      Pharmacology 76

      Pages: 157-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] カンナビノイド受容体を介した気道神経原性炎症の制御2006

    • Author(s)
      吉原 重美
    • Journal Title

      アレルギーと神ペプチド 2

      Pages: 4-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cannabinoid receptor agonists inhibit Ca^<2+> influx to synaptosomes from rat brain2006

    • Author(s)
      Yoshihara S, Morimoto H, Ohori M, Yamada Y, Abe T, Arisaka, O
    • Journal Title

      Pharmacology 76

      Pages: 157-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Control of neurogenic inflammation and Cannabinoid receptor(in Japanese)2006

    • Author(s)
      Yoshihara, S
    • Journal Title

      Nihonigakukan Allergy and Neuropeptide 2

      Pages: 4-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A neuroactive steroid inhibits guinea-pig airway sensory nerves via Maxi-K^+ channels activation.2006

    • Author(s)
      Yoshihara S et al.
    • Journal Title

      Int Arch Allergy Immunol 141

      Pages: 31-36

    • Related Report
      2006 Annual Research Report
  • [Presentation] 抗原誘発気退血漿漏出反応に対するカンナビノイド合成アゴニスト(WIN55212-2)の抑制効果2007

    • Author(s)
      福田 啓伸、吉原 重美, 他
    • Organizer
      第57回日本アレルギー学会秋季学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibitory effect of antigen-induced plasma extravasation by Cannabinoid receptor agonist(WIN55212-2) in guinea pig airways2007

    • Author(s)
      Fukuda H, Yoshihara S, Ono M, Yamada Y, Nishida M, Arisaka, O
    • Organizer
      The 57th Annual Meeting of Japanese Society of Allergology
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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