Pathophysiology of the cerebral hypoxia-ischemia-Evaluation using magnetic resonance spectroscopic imaging

• Project/Area Number: 18591216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MIYASAKA Naoyuki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 講師 (70313252)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
• Keywords: magnetic resonance spectroscopic imaging / cerebral hypoxia-ischemia / perinatal brain damage / spectroscopic imaging / cerebral hypoxia / asphyxia / magnetic resonance imaging / BO mapping / automatic shimming / rat brain / mouse brain

Research Abstract

小動物において非侵襲的に脳内生化学的変化を測定できる、magnetic resonance spectroscopicimaging 法を開発した。また本方法を用いて、脳性麻痺の主要な原因である低酸素性虚血性脳症の病態生理を研究し、新生児においては持続的な低酸素よりも、間歇的な低酸素の方が脳に有害であることが明らかとなった。

Research Products

• [Journal Article] Experimentalischemic brain edema : norphological andmagnetic resonance imaging findings (2007)
  • Author(s): Kuroiwa T, Miyasaka N, FengYu Z, Yamada I, Nakane M, Nagaoka T, Tamura A, Ohno K
  • Journal Title: Neurosurgical focus 22 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Efficacyof recombinant annexin 2 for fibrinolytictherapy in a rat embolic stroke model (2007)
  • Author(s): Tanaka Y, Ishii H, Hiraoka M, Miyasaka N, Kuroiwa T, Hajjar KA, Nagaoka T, Duong TQ, Ohno K, Yoshida M
  • Journal Title: Amagnetic resonance imaging study、Brain Research 1165 Pages: 135-143
  • Peer Reviewed
• [Journal Article] Chronic intermittentbut not constant hypoxia decreasesNAA/Cr ratios in neonatal mousehippocampus and thalamus (2007)
  • Author(s): Douglas RM, Miyasaka N, Takahashi K, Latuszek-Barrantes A, Haddad GG, Hetherington HP
  • Journal Title: AmericanJournal of Physiology-RegulatoryIntegrative & Comparative Physiology 292(3)
  • Peer Reviewed
• [Journal Article] Chronic intermittent but not constant hypoxia decreases NAA/Cr ratios in neonatal mouse hippocampus and thalamus (2007)
  • Author(s): Douglas RM
  • Journal Title: American Journal of Physiology-Regulatory Inte grative & Comparative Physiology. 292 Pages: 1254-1259
  • Peer Reviewed
• [Journal Article] Fully Automated Shim MappingMethod For Spectroscopic Imaging of theMouse Brain at 9.4T (2006)
  • Author(s): Miyasaka. N, Takahashi K, Hetherington HP
  • Journal Title: Magnetic Resonance in Medicine 55 Pages: 198-202
  • Peer Reviewed
• [Journal Article] 1H NMR Spectroscopic Imaging of the Mouse Brain at 9.4T (2006)
  • Author(s): Miyasaka. N, Takahashi K, Hetherington HP
  • Journal Title: Journal ofMagnetic Resonance Imaging 24 Pages: 908-913
  • Peer Reviewed
• [Journal Article] 1H NMR Spectroscopic Imaging of the Mouse Brain at 9.4T (2006)
  • Author(s): Naoyuki Miyasaka
  • Journal Title: Journal of Magnetic Resonance Imaging 24 Pages: 908-908
• [Presentation] 1H Mrspectroscopic imaging of the mousebrain-周産期脳障害の病態解明の試み (2008)
  • Author(s): 宮坂尚幸、久保田俊郎
  • Organizer: 第60回日本産科婦人科学会学術講演会
  • Place of Presentation: パシフィコ横浜
• [Presentation] B0 mappingを用いた自動shimming法の開発とマウス脳1H-Mrspectroscopic imagingへの応用 (2008)
  • Author(s): 宮坂尚幸
  • Organizer: 第36回日本磁気共鳴医学会大会
  • Place of Presentation: 旭川
• [Presentation] 1H MRspectroscopicimagingofthemousebrain-周産期脳障害の病態解明の試み (2008)
  • Author(s): 宮坂尚幸, 久保田俊郎
  • Organizer: 第60回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
• [Presentation] BO mappingを用いた自動 shimming 法の開発とマウス脳 1H-MR spectroscopic imaging への応用 (2008)
  • Author(s): 宮坂尚幸
  • Organizer: 第36回日本磁気共鳴医学会大会
  • Place of Presentation: 旭川
• [Presentation] MRIによるラット脳機能画像-周産期脳障害の病態解明の試み (2007)
  • Author(s): 宮坂尚幸、久保田俊郎
  • Organizer: 第59回日本産科婦人科学会学術講演会
  • Place of Presentation: 京都