| Project/Area Number |
18591220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
MIKI Takanori Kagawa University, 医学部, 准教授 (30274294)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Toshifumi 神戸大学, 農学部, 助教 (10380156)
MATSUMOTO Yoshiki 香川大学, 医学部, 助教 (90335844)
WARITA Katsuhiko 香川大学, 医学部, 助教 (40452669)
TAKEUCHI Yoshiki 香川大学, 医学部, 教授 (20116619)
KUSAKA Takashi 香川大学, 医学部附属病院, 講師 (50274288)
ITOH Susumu 香川大学, 医学部, 教授 (80145052)
李 京烈 香川大学, 医学部, 助手 (00403775)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,080,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | 母仔分離 / ストレス / 養育環境 / 母子間相互作用 / 脆弱性分子基盤 / 神経栄養因子 / 脳・神経発達 / 精神神経機能 / 母仔分離ストレス / 脳発達 / 脆弱性基盤 / ミエリン関連たんぱく質 / OMGp / 神経回路網形成 / エピジェネテック / 脳の脆弱性基盤 / 発達 / エネルギー代謝 / Prohibitin (PHB) / 脂肪 / BDNF mRNA / サイトカイン / 発達・成長 / Real-time RT-PCR |
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| Research Abstract |
Wistar male rats were separated from their mothers for 3 hours each day between PND10 and 15 (MD group). Nurotrophin ligand and receptor expressions were analyzed. The expression of BDNF/TrkB in MD rats was enhanced in both mRNA and protein levels. In contrast, no significant difference in NGF/TrkA expression level was observed between these groups. On the other hand, OMgp expression was elevated in MD animals. Abnormal fluctuations in those trophic factors cause organic changes, and ultimately lead to functional disturbance.
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