Effects of maternal care on brain development : molecular mechanism of mother-infant interactions

• Project/Area Number: 18591220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: MIKI Takanori Kagawa University, 医学部, 准教授 (30274294)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA Toshifumi 神戸大学, 農学部, 助教 (10380156) ; MATSUMOTO Yoshiki 香川大学, 医学部, 助教 (90335844) ; WARITA Katsuhiko 香川大学, 医学部, 助教 (40452669) ; TAKEUCHI Yoshiki 香川大学, 医学部, 教授 (20116619) ; KUSAKA Takashi 香川大学, 医学部附属病院, 講師 (50274288) ; ITOH Susumu 香川大学, 医学部, 教授 (80145052) ; 李 京烈 香川大学, 医学部, 助手 (00403775)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,080,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 母仔分離 / ストレス / 養育環境 / 母子間相互作用 / 脆弱性分子基盤 / 神経栄養因子 / 脳・神経発達 / 精神神経機能 / 母仔分離ストレス / 脳発達 / 脆弱性基盤 / ミエリン関連たんぱく質 / OMGp / 神経回路網形成 / エピジェネテック / 脳の脆弱性基盤 / 発達 / エネルギー代謝 / Prohibitin (PHB) / 脂肪 / BDNF mRNA / サイトカイン / 発達・成長 / Real-time RT-PCR

Research Abstract

Wistar male rats were separated from their mothers for 3 hours each day between PND10 and 15 (MD group). Nurotrophin ligand and receptor expressions were analyzed. The expression of BDNF/TrkB in MD rats was enhanced in both mRNA and protein levels. In contrast, no significant difference in NGF/TrkA expression level was observed between these groups. On the other hand, OMgp expression was elevated in MD animals. Abnormal fluctuations in those trophic factors cause organic changes, and ultimately lead to functional disturbance.

Research Products

• [Journal Article] Alcohol or Their Combination on Cholinergic Markers in the Frontal Cortex and Hippocampus of Rat. (2010)
  • Author(s): Jamal M, Ameno K, Miki T, Tanaka N, Ohkubo E, Kinoshita H. Effects of Systemic Nicotine
  • Journal Title: Neurochem Res. (in press)
  • Peer Reviewed
• [Journal Article] Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors: No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus (2010)
  • Author(s): Ueno T, Miki T, Wang ZY, Yokoyama T, Lee KY, Kusaka T, Warita K, Sumitani K, Matsumoto Y, Yakura T, Liu JQ, Bedi KS, Takeuchi Y.
  • Journal Title: Current Neurobiol. 1 Pages: 40-45
  • Peer Reviewed
• [Journal Article] GABA expression in c-Fos immunoreactive neurons of the rat periaqueductal gray induced by electroacupuncture at the point of Zusanli. (2010)
  • Author(s): Fusumada K, Yokoyama T, Miki T, Matsumoto Y, Warita K, Wang ZY, Yakura T, Liu JQ, Takeuch Y.
  • Journal Title: Current Neurobiol. 1 Pages: 10-13
  • Peer Reviewed
• [Journal Article] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum (2010)
  • Author(s): Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y
  • Journal Title: Neuroscience 165 Pages: 485-491
  • Peer Reviewed
• [Journal Article] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum (2010)
  • Author(s): Zhi-Yu Wang
  • Journal Title: Neuroscience 165 Pages: 485-491
  • Peer Reviewed
• [Journal Article] Effects of short-term ethanol ingestion on the expression of neurotrophins and their receptors : No changes in the expression of the glial-derived neurotrophic factor in the mouse hippocampus (2010)
  • Author(s): Takashi Ueno
  • Journal Title: Current Neurobiology 1 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models (2009)
  • Author(s): Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K, Ijiri I, Kinoshita H.
  • Journal Title: Brain Res. 27 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets (2009)
  • Author(s): Kusaka T, Ueno M, Miki T, Kuboi T, Nakamura S, Koyano K, Ijichi S, Yasuda S, Okubo K, Kawada K, Namba M, Nishida T, Imai T, Isobe K, Itoh S.
  • Journal Title: Pediatr Res. 65 Pages: 317-22
  • Peer Reviewed
• [Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models (2009)
  • Author(s): Mostofa Jamal
  • Journal Title: Brain Research 1295 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets (2009)
  • Author(s): Kusaka T, Ueno M, Miki T, Kuboi T, Nakamura S, Koyano K, Ijichi S, Yasuda S, Okubo K, Kawada K, Namba M, Nishida T, Imai T, Isobe K, Itoh S
  • Journal Title: Pediatr Res. 65 Pages: 317-22
  • Peer Reviewed
• [Journal Article] Japan Standard Stroke Registry Study Group. Predictors of ntracerebral hemorrhage severity and its outcome in Japanese stroke patients (2009)
  • Author(s): Hosomi N, Naya T, Ohkita H, Mukai M, Nakamura T, Ueno M, Dobashi H, Murao K, Masugata H, Miki T, Kohno M, Kobayashi S, Koziol JA
  • Journal Title: Cerebrovasc Dis. 7 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Relationship between cerebral oxygenation and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets (2009)
  • Author(s): Kusaka, et al.
  • Journal Title: Pediatr Res 65 Pages: 317-22
  • Peer Reviewed
• [Journal Article] Japan standard Stroke Registry study Group. Predictors of intracerebral hemorrhage severity and its outcome in Japanese stroke patients (2009)
  • Author(s): Hosomi, et al.
  • Journal Title: Cerebrovasc Dis 27 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus. (2008)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, Bedi KS, Itoh S, Nakamura Y, Takeuchi Y
  • Journal Title: Acta Neurobiol Exp. 68 Pages: 484-493
  • Peer Reviewed
• [Journal Article] Ethanol neurotoxicity and dentate gyrus development. (2008)
  • Author(s): Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita Y, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh, S, Takeuchi Y
  • Journal Title: Congenital Anomalies 48 Pages: 110-117
  • NAID: 10027387376
  • Peer Reviewed
• [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice (2008)
  • Author(s): Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima YI, Sasahara M, Funa K
  • Journal Title: Mol Cell Neurosci. 37 Pages: 507-518
  • Peer Reviewed
• [Journal Article] Activin A and equine chorionic gonadotropin recover reproductive dysfunction induced by neonatal exposure to an estrogenic endocrine disruptor in adult male mice. (2008)
  • Author(s): Warita K, Okamoto K, Mutoh KI, Hasegawa Y, Yue ZP, Yokoyama T, Matsumoto Y, Miki T, Takeuchi Y, Kitagawa H, Sugawara T, Hoshi N.
  • Journal Title: Biol Reprod. 78 Pages: 59-67
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus (2008)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, S Bedi K, Itoh S, Nakamura Y, Takeuchi Y.
  • Journal Title: Acta Neurobiol Exp (Wars) 68 Pages: 484-93
  • Peer Reviewed
• [Journal Article] Ethanol neurotoxicity and dentate gyrus development (2008)
  • Author(s): Miki T, Yokoyama T, Sumitani K, Kusaka T, Warita K, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh S, Takeuchi Y.
  • Journal Title: Congenit Anom (Kyoto) 48 Pages: 110-7
  • NAID: 10027387376
  • Peer Reviewed
• [Journal Article] Plasma brain natriuretic peptide as a surrogate marker for ardioembolic stroke (2008)
  • Author(s): Yukiiri K, Hosomi N, Naya T, Takahashi T, Ohkita H, Mukai M, Masugata H, Murao K, Ueno M, Nakamura T, Dobashi H, Miki T, Kuroda Y, Kohno M.
  • Journal Title: BMC Neurol 11 ; 8 Pages: 45-45
  • Peer Reviewed
• [Journal Article] Dietary protein modulates circadian changes in core body temperature and metabolic rate in rats (2008)
  • Author(s): Yamaoka I, Nakayama M, Miki T, Yokoyama T,Takeuchi Y.
  • Journal Title: J Physiol Sci. 58
  • NAID: 10022597776
  • Peer Reviewed
• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus. (2008)
  • Author(s): Miki, et al.
  • Journal Title: Acta Neurobiol Exp (Wars) 68 Pages: 484-93
  • Peer Reviewed
• [Journal Article] Ethanol neurotoxicity and dentate gyrus development (2008)
  • Author(s): Miki, et al.
  • Journal Title: Congenit Anom (Kyoto) 48 Pages: 110-117
  • NAID: 10027387376
  • Peer Reviewed
• [Journal Article] Dietary protein modulates circadian changes in core body temperature and metabolic rate in rats (2008)
  • Author(s): Yamaoka, et al.
  • Journal Title: J Physiol Sci 58 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Plasma brain natriuretic peptide as a surrogate marker for cardioembolic stroke (2008)
  • Author(s): Yukiiri, et al.
  • Journal Title: BMC Neurol 8 Pages: 45-45
  • Peer Reviewed
• [Journal Article] Dietary protein modulates circadian changes in core body temperature and metabolic rate in rats. (2008)
  • Author(s): Yamaoka I, Nakayama M, Miki T, Yokoyama T, Takeuchi Y.
  • Journal Title: JPhysiol Sci 58 Pages: 75-81
  • NAID: 10022597776
  • Peer Reviewed
• [Journal Article] 母性剥奪症侯群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ (2008)
  • Author(s): 三木 崇範
  • Journal Title: 日本未熟児新生児学会雑誌 20 Pages: 35-40
  • NAID: 10022598474
  • Peer Reviewed
• [Journal Article] Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde (2007)
  • Author(s): Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, Ijiri I
  • Journal Title: Neuroscience 144 Pages: 232-238
  • Peer Reviewed
• [Journal Article] The effect of prenatal X-irradiation on the developing cerebral cortex of rats. A quantitative assessment of glial cells in the somatosensory cortex (2007)
  • Author(s): Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumoto Y, Warita K, Lee NS, Fukui Y, Takeuchi Y
  • Journal Title: Int J Dev Neurosci. 25 Pages: 293-297
  • Peer Reviewed
• [Journal Article] The effect of prenatal X-irradiation on the developing cerebral cortex of rats.ll: A quantitative assessment of glial cells in the somatosensory cortex (2007)
  • Author(s): Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumoto Y, Warita K, Lee NS, Fukui Y, Takeuchi Y.
  • Journal Title: Int J Dev Neurosci. 25 Pages: 293-297
  • Peer Reviewed
• [Journal Article] Accumulation of triosephosphate isomerase,with sequence homology to Beta amyloid,peptides in vessel walls of the newborn piglet hippocampus (2007)
  • Author(s): Kusaka T, Ueno M, Miki T, et. al.
  • Journal Title: Microsc Res Tech. 70 Pages: 648-655
  • Peer Reviewed
• [Journal Article] c-Fos expression in the periaqueductal gray is induced by electroacupuncture in the rat,with possible reference to GABAergic neurons. (2007)
  • Author(s): Fusumada K, Yokoyama T, Miki T, Wang ZY, Yang W, Lee NS, Endo Y, Takeuchi Y.
  • Journal Title: Okajimas FoliaAnat Jpn 84 Pages: 1-9
  • NAID: 130004495030
  • Peer Reviewed
• [Journal Article] Changes in cholinergic function in the frontal cortex and hippocampus of ratexposed to ethanol and acetaldehyde. (2007)
  • Author(s): Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, ljiri I
  • Journal Title: Neuroscience 144 Pages: 232-238
  • Peer Reviewed
• [Journal Article] Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde. (2007)
  • Author(s): Jamal M et al.
  • Journal Title: Neuroscience 144・1 Pages: 232-238
• [Journal Article] Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption (2006)
  • Author(s): Okamoto H, Miki T, Lee KY, Yokoyama T, Kuma H, Wang ZY, Gu H, Li HP, Matsumoto Y, Irawan S, Bedi KS, Nakamura Y, Takeuchi Y
  • Journal Title: Neurosci Lett. 406 Pages: 76-80
  • Peer Reviewed
• [Journal Article] Age-related changes in growth hormone-immunoreactive cells in the anterior pituitary gland of Jcl: Wistar-TgN (ARGHGEN) 1Nts rats (Mini rats) (2006)
  • Author(s): Matsumoto Y, Tsukamoto Y, Miki T, Ogawa K, Lee KY, Yokoyama T, Satriotomo I, Li HP, Gu H, Wang ZY, Karasawa S, Ueda S, Sasaki F, Takeuchi Y.
  • Journal Title: Congenit Anom. (Kyoto) 46 Pages: 188-93
  • NAID: 10027385949
  • Peer Reviewed
• [Journal Article] Changes of parvalbumin immunoreactive neurons and GFAP immunoreactive astrocytes in the rat lateral geniculate nucleus following monocular enucleation. (2006)
  • Author(s): Gonzalez D et al.
  • Journal Title: Neurosci Lett. 395・2 Pages: 149-154
• [Journal Article] Age-related changes in growth hormone-immunoreactive cells in the anterior pituitary gland of Jcl : Wistar-TgN (ARGHGEN) 1Nts rats (Mini rats). (2006)
  • Author(s): Matsumoto Y et al.
  • Journal Title: Congenit Anom(Kyoto) 46・4 Pages: 188-193
  • NAID: 10027385949
• [Journal Article] Regional differences in vulnerability of the cerebellar foliations of rats exposed to neonatal X-irradiation. (2006)
  • Author(s): Li HP et al.
  • Journal Title: Neurosci Lett. 402・1-2 Pages: 86-91
• [Journal Article] Effects of chronic ethanol administration on the expression levels of neurotrophic factors in the rat hippocampus. (2006)
  • Author(s): Okamoto H et al.
  • Journal Title: Okajimas Folia Anat Jpn. 83・1 Pages: 1-6
• [Journal Article] Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption. (2006)
  • Author(s): Okamoto H et al.
  • Journal Title: Neurosci Lett 406・1-2 Pages: 76-80
• [Journal Article] 母性剥奪症候群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ
  • Author(s): 三木崇範
  • Journal Title: 日本未熟児新生児学会雑誌 第20巻第1号 Pages: 35-40
  • Peer Reviewed
• [Journal Article] 子供の脳発達と養育環境-母性剥奪症候群のエピジェネティック解析
  • Author(s): 三木崇範
  • Journal Title: 財団法人成長科学協会研究年報 第31巻 Pages: 189-190
  • Peer Reviewed
• [Presentation] 短期間アルコール摂取マウス小脳の神経栄養因子リガンド/レセプター系の特異的応答性 (2010)
  • Author(s): 三木崇範、汪治宇、横山俊史、日下隆、住谷和則、割田克彦、松本由樹、矢倉富子、劉俊騫、王朝暉、竹内義喜
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 岩手県民会館
• [Presentation] Non-vesicular synaptic transport: WGA- HRP and Rab3A-siRNA studies (2010)
  • Author(s): Yakura T, Matsumoto Y, Miki T, Warita K, Wang ZY, Liu JQ, Mamoru F, Takeuchi Y.
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 岩手県民会館
• [Presentation] 短期間アルコール摂取マウス小脳の神経栄養因子リガンド/レセプター系の特異的応答性 (2010)
  • Author(s): 三木崇範
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館(盛岡)
• [Presentation] A protein conjugation of WGA essential for transsynaptic tracer in neuronal system: application for Amyloid-βin vivo (2009)
  • Author(s): Takeuchi Y, Matsumoto Y, Miki T, Warita K, Wang ZY, Yakura T, Liu JQ.
  • Organizer: International Symposium on Early Detection and Rehabilitation Technology of Dementia
  • Place of Presentation: 岡山大学
• [Presentation] WGA結合タンパクがもたらすシナプス膜輸送機構の新展開 (2009)
  • Author(s): 松本由樹、三木崇範、割田克彦、汪治宇、矢倉富子、劉俊騫、竹内義喜
  • Organizer: 第64回日本解剖学会地方会
  • Place of Presentation: 高知大学
• [Presentation] WGA-HRPによる順行性シナプス輸送:ラット迷走神経へのRab3A-siRNA投与 (2009)
  • Author(s): 竹内義喜、松本由樹、三木崇範、横山俊史、割田克彦、汪治宇、矢倉富子、藤田守
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Modulation of hypothalamopituitary axis in Mini rat: further studies with hypophysiotropic somatostatin and gonadotroph (2009)
  • Author(s): Matsumoto Y, Miki T, Tsukamoto Y, Warita K, Wang ZY, Yakura T, Karasawa S, Ueda S, Takeuchi Y.
  • Organizer: The 8th World Congress on Neurohypophysial Hormones
  • Place of Presentation: 北九州国際会議場
• [Presentation] evaluation of anterograde synaptic transport of WGA-HRP in the rat (2009)
  • Author(s): 竹内義喜、三木崇範、横山俊史、松本由樹、割田克彦、汪治宇、上野貴士、藤田守
  • Organizer: 第114回日本解剖学会
  • Place of Presentation: 岡山理科大学
• [Presentation] Revaluation of anterograde synaptic transport of WGA-HRP in the rat (2009)
  • Author(s): 竹内義喜、三木崇範、横山俊史、松本由樹、割田克彦、汪治宇、上野貴士、藤田守
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学(岡山市)
• [Presentation] Revaluation of anterograde synaptic transport of WGA-HRP in the rat. (2009)
  • Author(s): 竹内義喜, 三木崇範, 横山俊史, 松本由樹, 割田克彦, 汪治宇, 上野貴士, 藤田守
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学(岡山市)
• [Presentation] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb. (2008)
  • Author(s): 松本由樹、三木崇範、谷賀、割田克彦、汪治宇、竹内義喜
  • Organizer: 第113回日本解剖学会
  • Place of Presentation: 大分大学
• [Presentation] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb (2008)
  • Author(s): 松本由樹、三木崇範、谷賀、割田克彦、汪治宇、竹内義喜
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部(由布市)
• [Presentation] ライディッヒ細胞株TTE1 におけるエストロゲン様化学物質曝露の影響 : ステロイドホルモン産生系遺伝子発現とヒストン修飾の変化 (2008)
  • Author(s): 割田克彦、三觜友子、菅原照夫、田渕圭章、松本由樹、三木崇範ら
  • Organizer: 第2回日本エピジェネティクス研究会年会
  • Place of Presentation: 東レ総合研修センター(三島市)
• [Presentation] 医学部における先天異常学教育-香川大学での試み- (2008)
  • Author(s): 三木崇範、割田克彦、松本由樹、日下隆、汪治宇、伊藤進、竹内義喜
  • Organizer: 第48回日本先天異常学会学術集会
  • Place of Presentation: 聖路加国際病院・聖路加看護大学(東京都)
• [Presentation] エストロゲン様化学物質曝露によるエストロゲンホルモン産生系遺伝子の発現変化とヒストンアセチル化解析 (2008)
  • Author(s): 割田克彦、三觜友子、菅原照夫、田渕圭章、松本由樹、三木崇範ら
  • Organizer: 第48回日本先天異常学会学術集会
  • Place of Presentation: 聖路加国際病院・聖路加看護大学(東京都)
• [Presentation] Y染色体腕間逆位を有するXY女性におけるSRY遺伝子のエピジェネティック異常 (2008)
  • Author(s): 三觜友子、割田克彦、菅原照夫、田渕圭章、高崎一郎、松本由樹、三木崇範ら
  • Organizer: 第48回日本先天異常学会学術集会
  • Place of Presentation: 聖路加国際病院・聖路加看護大学(東京都)
• [Presentation] ライディッヒ細胞株TTE1におけるエストロゲン様化学物質曝露の影響 : ステロイドホルモン産生系遺伝子発現とヒストン修飾の変化 (2008)
  • Author(s): 割田克彦, 三觜友子, 菅原照夫, 田渕圭章, 松本由樹, 三木崇範 ら
  • Organizer: 第2回日本エピジェネティクス研究会年会
  • Place of Presentation: 東レ総合研修センター(三島市)
• [Presentation] 医学部における先天異常学教育-香川大学での試み- (2008)
  • Author(s): 三木崇範, 割田克彦, 松本由樹, 日下隆, 汪治宇, 伊藤進, 竹内義喜
  • Organizer: 第48回日本先天異常学会学術集会
  • Place of Presentation: 聖路加国際病院ヽ聖路加看護大学(東京都)
• [Presentation] Early postnatal ethanol exposure alters the BDNF and neural interactions in the olfactory bulb (2008)
  • Author(s): 松本 由樹、三木 崇範, ら
  • Organizer: 第103回日本解剖学会
  • Place of Presentation: 由布市
• [Presentation] Takeuchi Y Short-term ethanol exposure caused changes in neurotrophins and its receptors expression in mice cerebellum. (2007)
  • Author(s): ang ZY, Miki T, Yokoyama T, Matsumoto Y, Warita K, Sumitani K, Lu F
  • Organizer: 第62回日本解剖学会地方会
  • Place of Presentation: 川崎医科大学
• [Presentation] Fos-immunoreactive neurons in the lateral central nucleus of amygdala activated by hypotension with special reference to the parabrachial nucleus in the rat (2007)
  • Author(s): akeuchi Y, Xie Q, Matsumoto Y, Warita K, Miki T.
  • Organizer: Italian Society of Neuroscience, Palazzo della Ragione e Palazzo della Gran Guardia
  • Place of Presentation: Verona, Italy
• [Presentation] Funa K A nobel enhancer of the PDGF beta-receptor gene activated uring the differentiation of neuroblastoma through GATA factor (2007)
  • Author(s): Matsumoto Y, Kaneko M, Yang W, Watt F, Warita K, Miki T, Takeuchi Y
  • Organizer: Italian Society of Neuroscience, Palazzo della Ragione e Palazzo della Gran Guardia
  • Place of Presentation: Verona, Italy
• [Presentation] 母性剥奪症侯群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ (2007)
  • Author(s): 三木崇範
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: サンポート高松
• [Presentation] 中枢神経発達時期におけるイソフルラン曝露の影響:嗅球における神経栄養因子の変化 (2007)
  • Author(s): 三木崇範、横山俊史、植木正明、汪治宇、割田克彦、松本由樹、前川信博、竹内義喜
  • Organizer: 第47回日本先天異常学会学術集会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 中枢神経発達時期におけるイソフルラン曝露の影響:臭球における神経栄養因子の変化 (2007)
  • Author(s): 三木 崇範
  • Organizer: 第47回日本先天異常学会学術集会
  • Place of Presentation: 名古屋市
• [Presentation] Short-term ethanol exposure caused changes in neurotrophins and its receptorexpressionin mice cerebellu. (2007)
  • Author(s): Zhi-Yu Wang, Miki T, et. al.
  • Organizer: 日本解剖学会第62回中国四国支部学術集会
  • Place of Presentation: 倉敷市
• [Presentation] 母性剥奪症侯群(Maternal Deprivation Syndrome)の発達神経科学的アプローチ (2007)
  • Author(s): 三木 崇範
  • Organizer: 第52回日本未熟児新生児学会
  • Place of Presentation: 高松市
• [Presentation] Neuroprotective Effects of Rare Sugar against Ethanol Toxicity; An Electron Microscopic Study in Mice Hippocampus. (2006)
  • Author(s): Takeuchi Y, Yokoyama T, Miki T, Wang ZY, Yang W, Ueno M.
  • Organizer: Rare Sugar Congress 2006 in Kagawa, The 3rd Symposium of International Society of Rare Sugars
  • Place of Presentation: かがわ国際会議場
• [Presentation] Activity of a novel PDGF b-receptor enhancer during the cel1 cycle and upon differentiation of neuroblastoma (2006)
  • Author(s): Yang W, Kaneko M, Matsumoto Y, Wang ZY, Yokoyama T, Miki T, Watt F, Funa K, Takeuchi Y.
  • Organizer: differentiation of neuroblastoma.第61回日本解剖学会地方会
  • Place of Presentation: 広島大学
• [Presentation] 母子間相互作用の発達神経科学解析;母性剥奪による脳発達への影響 (2006)
  • Author(s): 三木崇範、横山俊史、日下隆、汪治宇、松本由樹、楊衛文、伊藤進、竹内義喜
  • Organizer: 第6回日本赤ちゃん学会
  • Place of Presentation: 福井商工会議所
• [Presentation] 組織定量解析法(ステレオロジー)を用いた中枢神経系の機能解析 (2006)
  • Author(s): 三木崇範
  • Organizer: 第46回日本先天異常学会学術集会
  • Place of Presentation: 山形テルサ
• [Presentation] Activity of a novel PDGF beta-receptor enhancer during the cell cycle and upon differentiation of neuroblastoma (2006)
  • Author(s): Kaneko M, Yang W, Matsumoto Y, Watt F, Funa K.
  • Organizer: The 2nd IFOM-IEO, IFOM-IEO Campus
  • Place of Presentation: Milano, Italy
• [Presentation] 長期アルコール摂取によるラット海馬のミエリン構成たんぱく質mRNAの発現量変化 (2006)
  • Author(s): 三木崇範、横山俊史、李京烈、岡本華代、山岡一平、襖田和敏、今川智敬、竹内義喜
  • Organizer: 第111回日本解剖学会
  • Place of Presentation: 北里大学
• [Book] Effects of electric or magnetic brain stimulation on cortical and subcortical neuron functions in rats. (2007)
  • Author(s): Touge T, Gonzalez D, Miki T, Hiramine C, Takeuchi H.
  • Publisher: In Complex Medical Engineering, Springer
• [Book] Complex Medical Engineering (2007)
  • Author(s): Touge T, Gonzalez D, Miki T, Hiramine C, Takeuchi H
  • Total Pages: 6
  • Publisher: Effects of Electric or Magnetic Brain Stimulation on Cortical and Subcortical Neural Functions in Rats