Search for susceptibility genes in relation to the abnormalities of brain morphology or exploratory eye movements in schizophrenia

• Project/Area Number: 18591277
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Toyama
• Principal Investigator: TSUNODA Masahiko University of Toyama, 大学病院, 講師 (30322762)
• Co-Investigator(Kenkyū-buntansha): 鈴木 道雄 富山大学, 大学院・医学薬学研究部, 教授 (40236013) ; 住吉 太幹 富山大学, 大学院・医学薬学研究部, 准教授 (80286062) ; 高橋 努 (高橋 務) 富山大学, 大学院・医学薬学研究部, 助教 (60345577) ; 倉知 正佳 富山大学, 大学院・医学薬学研究部, 教授 (80019603) ; 恒枝 宏史 富山大学, 大学院・医学薬学研究部, 准教授 (20332661)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Michio 富山大学, 大学院・医学薬学研究部, 教授 (40236013) ; SUMIYOSHI Tomiki 富山大学, 大学院・医学薬学研究部, 准教授 (80286062) ; TAKAHASHI Tsutomu 富山大学, 大学院・医学薬学研究部, 助教 (60345577) ; KURACHI Masayoshi 富山大学, 大学院・医学薬学研究部, 教授 (80019603) ; TSUNEKI Hiroshi 富山大学, 大学院・医学薬学研究部, 准教授 (20332661)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,220,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 統合失調症 / 脳形態 / 疾患感受性遺伝子 / 探索眼球運動 / 疾患感受性遣伝子

Research Abstract

インフォームド・コンセントの得られた統合失調症患者と健常者において、高解像度三次元MRIを撮像し各脳部位を測定し、その脳の形態学的変化と種々の候補遺伝子の多型との関係を調べた結果、非常に興味深い知見が得られた。

Research Products

• [Journal Article] Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia (2009)
  • Author(s): Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawamura Y, Zhou S-Y, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
  • Journal Title: Psychiatry Research : Neuroimaging 172 Pages: 128-135
  • Peer Reviewed
• [Journal Article] Exploratory eye movement dysfunction as a discriminator for schizophrenia: A large sample study using a newly developed digital computerized system (2009)
  • Author(s): Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T
  • Journal Title: Eur Arch Psychiatry Clin Neurosci 259 Pages: 186-194
  • Peer Reviewed
• [Journal Article] The Disrupted in -Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. (2009)
  • Author(s): Tsutomu Takahashi, et al.
  • Journal Title: Psychiatry Research 172 Pages: 128-135
  • Peer Reviewed
• [Journal Article] Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons (2008)
  • Author(s): Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Tsuneki H, Kawasaki Y, Shi-Yu Zhou, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
  • Journal Title: Neurosci Lett 435 Pages: 34-39
  • Peer Reviewed
• [Journal Article] The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesion interthalamica and medial temporal lobe structures (2008)
  • Author(s): Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Maeno N Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
  • Journal Title: Progress in Neuro-Psychopharmacolo& Biological Psychiatry 32 Pages: 1236-1242
  • Peer Reviewed
• [Journal Article] Calcineirin A gamma and B gene expression in the whole blood in Japanese patients with schizophrenia (2008)
  • Author(s): Murata M, Tsunoda M, Sumiyoshi T, Sumiyoshi C, Matsuoka T, Suzuki M, Ito H, Kurachi M
  • Journal Title: Progress in Neuro-Psychopharmacolo & Biological Psychiatry 32 Pages: 1000-1004
  • Peer Reviewed
• [Journal Article] Effect of MK-801 on gene expressions in the amygdale of rats (2008)
  • Author(s): Matsuoka T, Tsunoda M, Sumiyoshi T, Takasaki I, Tabuchi Y, Seo T, Tanaka k, Uehara T, Itoh H, Suzuki M, Kurachi M
  • Journal Title: Synapse 62 Pages: 1-7
  • Peer Reviewed
• [Journal Article] The association of genotypic combination of the DRD3 and BDNF polymorphisms on adhesio inthalamica and medial temporal lobe structures. (2008)
  • Author(s): Tsutomu Takahashi, et al.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 Pages: 1236-1242
  • Peer Reviewed
• [Journal Article] Calcineurin A gamma and B gene expression in the whole blood in Japanese patients with schizophrenia (2008)
  • Author(s): Masahiko Murata, et al
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 Pages: 1000-1004
  • Peer Reviewed
• [Journal Article] Association between the brain-derived neurotrophic factor Va166Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons. (2008)
  • Author(s): Takahashi T., Suzuki M., Tsunoda M., Kawamura Y., Takahashi N., Tsuneki H., et. al.
  • Journal Title: Neuroscience Letters 435 Pages: 34-39
  • Peer Reviewed
• [Journal Article] Effect of MK-801 on gene expressions in the amygdale of rats. (2008)
  • Author(s): Matsuoka T., Tsunoda M., et. Al
  • Journal Title: Synapse 62 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Novel G423S mutation of human α7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase c-dependent mechanism. Mol (2007)
  • Author(s): Tsuneki H., Kobayashi S., Takagi K., Kagawa S., Tsunoda M., Murata M., Matsuoka T., Wada T., Kurachi M., Kimura I. and Sasaoka T
  • Journal Title: Pharmacol 71 Pages: 777-786
  • Peer Reviewed
• [Journal Article] Novel G423S mutation of human α7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependentmechanism. (2007)
  • Author(s): Tsuneki H., Kobayashi S., Takagi K., Kagawa S., Tsunoda M., Murata M., et. al.
  • Journal Title: Molecular Pharmacology 71 Pages: 777-786
  • Peer Reviewed
• [Presentation] Association between the BDNF Val66Met polymorphism and brain Morphology in schizophrenia. (2008)
  • Author(s): Masahiko Tsunoda, et al.
  • Organizer: The 2nd World Federation of Societies of Biological Psychiatry (WFSBP) Asia-Pacific Congress
  • Place of Presentation: 富山
  • Year and Date: 2008-09-13
• [Presentation] Genotypic interaction effect of DRD3 and BDNF on the adhesio interthalamica and hippocampus. (2008)
  • Author(s): Masahiko Tsunoda, et al.
  • Organizer: The 2nd World Federation of Societies of Biological Psychiatry (WFSBP) Asia-Pacific Congress
  • Place of Presentation: 富山
  • Year and Date: 2008-09-13
• [Presentation] Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons (2008)
  • Author(s): Tsunoda M
  • Organizer: 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: Toyama
• [Presentation] The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesion interthalamica and medial temporal lobe structures (2008)
  • Author(s): Tsunoda M, Suzuki M, Kawamura Y, Takahashi N, Maeno N, Kawasaki Y, Shi-Yu Zhou, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
  • Organizer: 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: Toyama
• [Presentation] Effect of MK-801 on gene expressions in the amygdale of rats (2008)
  • Author(s): Matsuoka T, Tsunoda M, Sumiyoshi T, Takasaki I, Tabuchi Y, Seo T, Tanaka k, Uehara T, Itoh H, Suzuki M, Kurachi M
  • Organizer: CINP
  • Place of Presentation: Munchen
• [Presentation] Structural brain changes underlying vulnerability to schizophrenia. In symposium (organized by Yui K. and Suzuki M.): Stress in the Development of Schizophrenia (2007)
  • Author(s): Suzuki M
  • Organizer: The 2nd World Conference of Stress
  • Place of Presentation: Budapest