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Search for susceptibility genes in relation to the abnormalities of brain morphology or exploratory eye movements in schizophrenia

Research Project

Project/Area Number 18591277
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

TSUNODA Masahiko  University of Toyama, 大学病院, 講師 (30322762)

Co-Investigator(Kenkyū-buntansha) 鈴木 道雄  富山大学, 大学院・医学薬学研究部, 教授 (40236013)
住吉 太幹  富山大学, 大学院・医学薬学研究部, 准教授 (80286062)
高橋 努 (高橋 務)  富山大学, 大学院・医学薬学研究部, 助教 (60345577)
倉知 正佳  富山大学, 大学院・医学薬学研究部, 教授 (80019603)
恒枝 宏史  富山大学, 大学院・医学薬学研究部, 准教授 (20332661)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Michio  富山大学, 大学院・医学薬学研究部, 教授 (40236013)
SUMIYOSHI Tomiki  富山大学, 大学院・医学薬学研究部, 准教授 (80286062)
TAKAHASHI Tsutomu  富山大学, 大学院・医学薬学研究部, 助教 (60345577)
KURACHI Masayoshi  富山大学, 大学院・医学薬学研究部, 教授 (80019603)
TSUNEKI Hiroshi  富山大学, 大学院・医学薬学研究部, 准教授 (20332661)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,220,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords統合失調症 / 脳形態 / 疾患感受性遺伝子 / 探索眼球運動 / 疾患感受性遣伝子
Research Abstract

インフォームド・コンセントの得られた統合失調症患者と健常者において、高解像度三次元MRIを撮像し各脳部位を測定し、その脳の形態学的変化と種々の候補遺伝子の多型との関係を調べた結果、非常に興味深い知見が得られた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (6 results)

  • [Journal Article] Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia2009

    • Author(s)
      Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawamura Y, Zhou S-Y, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
    • Journal Title

      Psychiatry Research : Neuroimaging 172

      Pages: 128-135

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exploratory eye movement dysfunction as a discriminator for schizophrenia: A large sample study using a newly developed digital computerized system2009

    • Author(s)
      Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci 259

      Pages: 186-194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Disrupted in -Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.2009

    • Author(s)
      Tsutomu Takahashi, et al.
    • Journal Title

      Psychiatry Research 172

      Pages: 128-135

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons2008

    • Author(s)
      Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Tsuneki H, Kawasaki Y, Shi-Yu Zhou, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
    • Journal Title

      Neurosci Lett 435

      Pages: 34-39

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesion interthalamica and medial temporal lobe structures2008

    • Author(s)
      Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Maeno N Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
    • Journal Title

      Progress in Neuro-Psychopharmacolo& Biological Psychiatry 32

      Pages: 1236-1242

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcineirin A gamma and B gene expression in the whole blood in Japanese patients with schizophrenia2008

    • Author(s)
      Murata M, Tsunoda M, Sumiyoshi T, Sumiyoshi C, Matsuoka T, Suzuki M, Ito H, Kurachi M
    • Journal Title

      Progress in Neuro-Psychopharmacolo & Biological Psychiatry 32

      Pages: 1000-1004

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of MK-801 on gene expressions in the amygdale of rats2008

    • Author(s)
      Matsuoka T, Tsunoda M, Sumiyoshi T, Takasaki I, Tabuchi Y, Seo T, Tanaka k, Uehara T, Itoh H, Suzuki M, Kurachi M
    • Journal Title

      Synapse 62

      Pages: 1-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association of genotypic combination of the DRD3 and BDNF polymorphisms on adhesio inthalamica and medial temporal lobe structures.2008

    • Author(s)
      Tsutomu Takahashi, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 32

      Pages: 1236-1242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcineurin A gamma and B gene expression in the whole blood in Japanese patients with schizophrenia2008

    • Author(s)
      Masahiko Murata, et al
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 32

      Pages: 1000-1004

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between the brain-derived neurotrophic factor Va166Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons.2008

    • Author(s)
      Takahashi T., Suzuki M., Tsunoda M., Kawamura Y., Takahashi N., Tsuneki H., et. al.
    • Journal Title

      Neuroscience Letters 435

      Pages: 34-39

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of MK-801 on gene expressions in the amygdale of rats.2008

    • Author(s)
      Matsuoka T., Tsunoda M., et. Al
    • Journal Title

      Synapse 62

      Pages: 1-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel G423S mutation of human α7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase c-dependent mechanism. Mol2007

    • Author(s)
      Tsuneki H., Kobayashi S., Takagi K., Kagawa S., Tsunoda M., Murata M., Matsuoka T., Wada T., Kurachi M., Kimura I. and Sasaoka T
    • Journal Title

      Pharmacol 71

      Pages: 777-786

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel G423S mutation of human α7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependentmechanism.2007

    • Author(s)
      Tsuneki H., Kobayashi S., Takagi K., Kagawa S., Tsunoda M., Murata M., et. al.
    • Journal Title

      Molecular Pharmacology 71

      Pages: 777-786

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association between the BDNF Val66Met polymorphism and brain Morphology in schizophrenia.2008

    • Author(s)
      Masahiko Tsunoda, et al.
    • Organizer
      The 2nd World Federation of Societies of Biological Psychiatry (WFSBP) Asia-Pacific Congress
    • Place of Presentation
      富山
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genotypic interaction effect of DRD3 and BDNF on the adhesio interthalamica and hippocampus.2008

    • Author(s)
      Masahiko Tsunoda, et al.
    • Organizer
      The 2nd World Federation of Societies of Biological Psychiatry (WFSBP) Asia-Pacific Congress
    • Place of Presentation
      富山
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons2008

    • Author(s)
      Tsunoda M
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      Toyama
    • Related Report
      2008 Final Research Report
  • [Presentation] The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesion interthalamica and medial temporal lobe structures2008

    • Author(s)
      Tsunoda M, Suzuki M, Kawamura Y, Takahashi N, Maeno N, Kawasaki Y, Shi-Yu Zhou, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      Toyama
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of MK-801 on gene expressions in the amygdale of rats2008

    • Author(s)
      Matsuoka T, Tsunoda M, Sumiyoshi T, Takasaki I, Tabuchi Y, Seo T, Tanaka k, Uehara T, Itoh H, Suzuki M, Kurachi M
    • Organizer
      CINP
    • Place of Presentation
      Munchen
    • Related Report
      2008 Final Research Report
  • [Presentation] Structural brain changes underlying vulnerability to schizophrenia. In symposium (organized by Yui K. and Suzuki M.): Stress in the Development of Schizophrenia2007

    • Author(s)
      Suzuki M
    • Organizer
      The 2nd World Conference of Stress
    • Place of Presentation
      Budapest
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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