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Association between COMT gene polymorphism and the frontal cortex function with near-infrared monitoring system : comparative study among ADHD and their families.

Research Project

Project/Area Number 18591314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa Medical University

Principal Investigator

JIBIKI Itsuki (2007-2008)  Kanazawa Medical University, 医学部, 教授 (60110532)

榎戸 芙佐子 (2006)  金沢医科大学, 医学部, 助教授 (80102052)

Co-Investigator(Kenkyū-buntansha) 廣保 究  金沢医科大学, 医学部, 助教 (20410318)
字引 逸亀  金沢医科大学, 医学部, 教授 (60110532)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,730,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsADHD / COMT / 衝動性 / 新奇性追求 / DRD4 / DAT1 / ドパミン遺伝子多型 / ドーパミン / 遺伝子多型 / 前頭葉機能 / 近赤外線酸素モニター / 家族 / COMT多型 / ドーパミン分解能 / 強迫性症状 / 自閉性症状 / 認知機能
Research Abstract

ADHD(注意欠陥多動障害)は遺伝的に複雑な疾患であるが遺伝性は0.76と報告されている。15人のADHD(男性12、女性3、全員が混合型)と家族の49人でドパミン系遺伝子多型を分析した。COMTはValine/Valine型が一般対照群より多く(ADHD本人7/15、家族16/34)、DRD4では7-repeat alleleはなかったが5-repeatが2人いた。DAT1は1家族4人を除く残り45名が10-repeat alleleだった。遺伝子多型と衝動性、新奇性追求の指標との関連性は統計的有意差がなかった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (3 results)

All 2008 2006

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] Symposium : How can we define the AD/HD concept and reach the diagnosis through objective assessment of behavioral symptoms in children? Symptomatology of AD/HD considered from qualitative aspects of obsessive-compulsive and autistic behaviors.2006

    • Author(s)
      Fusako Enokido, Fukumi Kitamoto, Masako Ohara, Itsuki Jibiki
    • Journal Title

      17^<th> International Association for Child and Adolescent Psychiatry and Allied Professions Congress. Abstract Book

      Pages: 226-226

    • Related Report
      2006 Annual Research Report
  • [Presentation] ADHDとその家族におけるCOMTおよびDRD4の解析2008

    • Author(s)
      榎戸芙佐子, 北本福美, 小泉葉月, 地引逸亀, 堀内真希
    • Organizer
      第49回日本児童青年精神医学会
    • Place of Presentation
      広島市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Symposium AD/HD Symptomatology of AD/HD considered from qualitative aspects of obsessive-compulsive and autistic behaviors2006

    • Author(s)
      Fusako Enokid, Fukumi Kitamoto, Masako Ohara, Itsuki Jibiki.
    • Organizer
      17th IACAPAP World Congress, 2006
    • Place of Presentation
      Melbourne
    • Year and Date
      2006-09-12
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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