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Molecular mechanisms of schizophrenia and pharmacogenetics in the treatment of schizophrenia

Research Project

Project/Area Number 18591319
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SHINKAI Takahiro  University of Occupational and Environmental Health, Japan, 医学部, 講師 (20352304)

Co-Investigator(Kenkyū-buntansha) HORI Hiroko  産業医科大学, 医学部, 非常勤助教 (80412641)
OHMORI Osamu  産業医科大学, 医学部, 非常勤講師 (70248558)
MATSUMOTO Chima  産業医科大学, 医学部, 非常勤助教 (80421329)
NAOE Yui  産業医科大学, 医学部, 専門修練医 (10421330)
UTSUNOMIYA Kensuke  産業医科大学, 医学部, 助教 (90425314)
FUKUNAKA Yuko  産業医科大学, 医学部, 専門修練医 (60441854)
INOUE Yoshiaki  産業医科大学, 医学部, 助教 (10461550)
YAMAGUCHI Wakana  産業医科大学, 医学部, 専門修練医 (20461551)
中村 純  産業医科大学, 医学部, 教授 (40148804)
坂田 深一  産業医科大学, 医学部, 助教 (80425313)
Co-Investigator(Renkei-kenkyūsha) NAKAMUARA Jun  産業医科大学, 医学部, 教授 (40148804)
SAKATA Shinichi  産業医科大学, 医学部, 助教 (80425313)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords統合失調症 / 遺伝子多型 / 関連研究 / 遅発性ジスキネジア / 水中毒 / オーダーメイド医療
Research Abstract

統合失調症の脆弱性(病気のかかりやすさ)、治療薬の効き目、さらに副作用の出やすさについて、遺伝的要因が関わっているという考えがあります。本研究は、それぞれ関与が予想される遺伝子の個人差を調べ、病気の診断、予防、治療に役立てようとするものです。研究した対象数がそれほど多くはなく、決定的とはいえませんが、いくつかの知見が得られました。このような研究結果が蓄積・確認されると、統合失調症のより無駄のなく合理的な診断や治療に寄与していくものと思われます。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (52 results)

All 2009 2008 2007 2006

All Journal Article (28 results) (of which Peer Reviewed: 23 results) Presentation (22 results) Book (2 results)

  • [Journal Article] Association analysis between the C-1291G polymorphism in the promoter region of the adrenergic α2A receptor gene and polydipsia in schizophrenia.2009

    • Author(s)
      Yamaguchi W, Shinkai T, Inoue Y, Utsunomiya K, Sakata S, Fukunaka Y, Yamada K, Chen HI, Hwang R, Ohmori O, Nakamura J.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between a functional polymorphism in the promoter region of the neuropeptide Y gene (-485C>T) and schizophrenia.2009

    • Author(s)
      Inoue Y, Shinkai T, Utsunomiya K, Sakata S, Fukunaka Y, Yamaguchi W, Yamada K, Chen HI, Hwang R, Ohmori O, Nakamura J.
    • Journal Title

      Neurosci Lett. 452(1)

      Pages: 72-4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis between the C-1291G polymorphism in the promoter region of the adrenergic α 2A receptor gene and polydipsia in schizophrenia.2009

    • Author(s)
      Yamaguchi, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology and biological psychiatry 33

      Pages: 499-502

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MDR1 gene in tardive dyskinesia scale scores : Comparison of strategies for quantitative trait haplotype analysis.2009

    • Author(s)
      De Luca, et al.
    • Journal Title

      Schizophrenia Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations : evidence from a case-control study and meta-analysis.2008

    • Author(s)
      Utsunomiya K, Shinkai T, De Luca V, Hwang R, Sakata S, Fukunaka Y, Chen HI, Ohmori O, Nakamura J.
    • Journal Title

      Neurosci Lett. 444(2)

      Pages: 161-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional polymorphism of the human multidrug resistance gene (MDR1) and polydipsia-hyponatremia in schizophrenia2008

    • Author(s)
      Shinkai T, De Luca V, Utsunomiya K, Sakata S, Inoue Y, Fukunaka Y, Hwang R, Ohmori O, Kennedy JL, Nakamura J.
    • Journal Title

      Neuromolecular Med. 10(4)

      Pages: 362-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations : evidence from a case-control study and meta-analysis.2008

    • Author(s)
      Utsunomiya, et al.
    • Journal Title

      Neuroscience letters 444

      Pages: 161-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between a functional polymorphism in the promoter region of the neuropeptide Y gene (-485C>T) and schizophrenia.2008

    • Author(s)
      Inoue, et al.
    • Journal Title

      Neuroscience letters 452

      Pages: 72-74

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional polymorphism of the human multidrug resistance gene (MDR1) and polydipsia-hyponatremia in schizophrenia.2008

    • Author(s)
      Shinkai, et al.
    • Journal Title

      NeuroMolecular Medicine 10

      Pages: 362-367

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia.2007

    • Author(s)
      Fukunaka Y, Shinkai T, Hwang R, Hori H, Utsunomiya K, Sakata S, Naoe Y, Shimizu K, Matsumoto C, Ohmori O, Nakamura J.
    • Journal Title

      Neuromolecular Med. 9(4)

      Pages: 292-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia : further evidence for a role in schizophrenia.2007

    • Author(s)
      Shinkai T, De Luca V, Hwang R, Muller DJ, Lanktree M, Zai G, Shaikh S, Wong G, Sicard T, Potapova N, Trakalo J, King N, Matsumoto C, Hori H, Wong AH, Ohmori O, Macciardi F, Nakamura J, Kennedy JL.
    • Journal Title

      Neuromolecular Med. 9(2)

      Pages: 169-77

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations : Evidence from a case-control study and meta-analysis.2007

    • Author(s)
      Naoe Y, Shinkai T, Hori H, Fukunaka Y, Utsunomiya K, Sakata S, Matsumoto C, Shimizu K, Hwang R, Ohmori O, Nakamura J.
    • Journal Title

      Neurosci Lett. 415(2)

      Pages: 108-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response.2007

    • Author(s)
      Hwang R, Shinkai T, De Luca V, Ni X, Potkin SG, Lieberman JA, Meltzer HY, Kennedy JL.
    • Journal Title

      J Psychopharmacol. 21(7)

      Pages: 718-27

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the brain-derived neurotrophic factor(BDNF)Val66Met polymorphism and schizophrenia in Asian populations:Evidence from a case-control study and meta-analysis2007

    • Author(s)
      Y.Naoe, et. al.
    • Journal Title

      Neuroscience letters 415(2)

      Pages: 108-112

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia:further evidence for a role in schizophrenia2007

    • Author(s)
      T.Shinkai, et. al.
    • Journal Title

      NeuroMolecular Medicine 9(2)

      Pages: 169-178

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of four dopamine D1 receptor gene polymorphisms and clozapine treatment response2007

    • Author(s)
      R.Hwang, et. al.
    • Journal Title

      Journal of psychopharmacology 21(7)

      Pages: 718-727

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia2007

    • Author(s)
      Y.Fukunaka, et. al.
    • Journal Title

      NeuroMolecular Medicine 9(4)

      Pages: 292-297

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗精神病薬による水中毒をどう予測するか2007

    • Author(s)
      新開 隆弘, 他
    • Journal Title

      臨床精神薬理 10(8)

      Pages: 1423-1431

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G72とD-アミノ酸酸化酵素(DAAO)2007

    • Author(s)
      新開 隆弘
    • Journal Title

      Schizophrenia Frontier 8(3)

      Pages: 34-41

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Association study between functional polymorphisms in the cytochrome P450 1A2 and 2D6 genes and polydipsia in schizophrenia.2006

    • Author(s)
      Matsumoto C, Shinkai T, De Luca V, Hori H, Hwang R, Ohmori O, Kennedy JL, Nakamura J.
    • Journal Title

      Neuromolecular Med. 8(3)

      Pages: 381-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between a functional NAD(P)H : quinone oxidoreductase gene polymorphism (Pro187Ser) and tardive dyskinesia.2006

    • Author(s)
      Hori H, Shinkai T, Matsumoto C, Ohmori O, Nakamura J.
    • Journal Title

      Neuromolecular Med. 8(3)

      Pages: 375-80

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment.2006

    • Author(s)
      Hwang R, Shinkai T, Deluca V, Macciardi F, Potkin S, Meltzer HY, Kennedy JL.
    • Journal Title

      Eur Neuropsychopharmacol. 16(4)

      Pages: 248-59

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia.2006

    • Author(s)
      Shinkai T, Muller DJ, De Luca V, Shaikh S, Matsumoto C, Hwang R, King N, Trakalo J, Potapova N, Zai G, Hori H, Ohmori O, Meltzer HY, Nakamura J, Kennedy JL.
    • Journal Title

      Psychiatry Res. 141(2)

      Pages: 123-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia.2006

    • Author(s)
      Shinkai T, Matsumoto C, Shaikh S, De Luca V, Muller DJ, Hwang R, King N, Trakalo J, Potapova N, Hori H, Ohmori O, Meltzer HY, Nakamura J, Kennedy JL
    • Journal Title

      Psychiatry Res. 141(2)

      Pages: 123-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study between functional polymorphisms in the cytochrome P450 1A2 and 2D6 genes and polydipsia in schizophrenia.2006

    • Author(s)
      C.Matsumoto, et al.
    • Journal Title

      NeuroMolecular Medicine 8(3)

      Pages: 381-388

    • Related Report
      2006 Annual Research Report
  • [Journal Article] No association between a functional NAD(P)H : quinone oxidoreductase gene polymorphism (pro187Ser) and tardive dyskinesia.2006

    • Author(s)
      H.Hori, et al.
    • Journal Title

      NeuroMolecular Medicine 8(3)

      Pages: 375-388

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia.2006

    • Author(s)
      T.Shinkai, et al.
    • Journal Title

      Psychiatry Research 141(2)

      Pages: 123-128

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dopamine D2 receptor gene variants and quantitative measures of positive and negative symptom response following clozapine treatment.2006

    • Author(s)
      R.Hwang, et al.
    • Journal Title

      European neuropsychopharmacology 16(4)

      Pages: 248-259

    • Related Report
      2006 Annual Research Report
  • [Presentation] Ethnic differences in pharmacogenetics of serious adverse effects of antipsychotics : tardive dyskinesia and more.2008

    • Author(s)
      Takahiro Shinkai, Hiroko Hori, Kensuke Utsunomiya, Chima Matsumoto, Shinichi Sakata, Yoshiaki Inoue, Yuko Fukunaka, Wakana Yamaguchi, Hsin-I Chen, Rudi Hwang, Vincenzo De Luca Daniel J. Muller, Osamu Ohmori, James L. Kennedy, Jun Nakamura.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Final Research Report
  • [Presentation] Association study between the NMDA receptor subunit 2B (GRIN2B) gene and polydipsia in schizophrenia.2008

    • Author(s)
      Takahiro Shinkai, Shinichi Sakata, Hiroko Yamamoto, Kensuke Utsunomiya, Yuko Fukunaka, Yoshiaki Inoue, Wakana Yamaguchi, Kenji Yamada, Hsin-I Chen, Osamu Ohmori, Jun Nakamura.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Final Research Report
  • [Presentation] Association between the leptin receptor gene (LEPR) polymorphism (Gln223Arg) and late-onset Alzheimer's disease.2008

    • Author(s)
      Kensuke Utsunomiya, Takahiro Shinkai, Shinichi Sakata, Yoshiaki Inoue, Yuko Fukunaka, Wakana Yamaguchi, Kenji Yamada, Osamu Ohmori, Jun Nakamura.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Final Research Report
  • [Presentation] Association study between the DNA repair gene XRCC1 and schizophrenia.2008

    • Author(s)
      Kenji Yamada, Takahiro Shinkai, Shinichi Sakata, Kensuke Utsunomiya, Yuko Fukunaka, Osamu Ohmori, Jun Nakamura.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic association analysis between the NMDA receptor subunit 2B gene and schizophrenia.2008

    • Author(s)
      Shinichi Sakata, Takahiro Shinkai, Hiroko Yamamoto, Kensuke Utsunomiya, Yoshiaki Inoue, Yuko Fukunaka, Wakana Yamaguchi, Kenji Yamada, Kazuko Shimizu, Hsin-I Chen, Osamu Ohmori, Jun Nakamura.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic association analysis between the NPR-1 gene polymorphism (M341I) and polydipsia in schizophrenia.2008

    • Author(s)
      Yuko Fukunaka , Takahiro Shinkai, Hsin-I Chen , Kensuke Utsunomiya ,Shinichi Sakata, Osamu Ohmori, Jun Nakamura.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka
    • Related Report
      2008 Final Research Report
  • [Presentation] NMDA型グルタミン酸受容体2B(GRIN2B)遺伝子多型と統合失調症における病的多飲2008

    • Author(s)
      新開隆弘, 他
    • Organizer
      2^<nd> WFSBP Asia-Pacific Congress and 30^<th> Annual Meeting of JSBP
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] NMDA受容体遺伝子(GRIN2B)と統合失調症における病的多飲2008

    • Author(s)
      Shinkai, et al.
    • Organizer
      第18回日本臨床精神神経薬理学会第38回日本神経精神薬理学会 合同年会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ethnic difference in pharmacogenetics of serious adverse effects of antipsychotics : tardive dyskinesia and more2008

    • Author(s)
      Shinkai, et al.
    • Organizer
      16^<th> World Congress on Psychiatric Genetics
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association between the NMDA receptor subunit 2B (GRIN2B) gene and polydipsia in schizophrenia2008

    • Author(s)
      Shinkai, et al.
    • Organizer
      16^<th> World Congress on Psychiatric Genetics
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症における病的多飲とドーパミンD3受容体遺伝子多型(SergGly)との関連2007

    • Author(s)
      宇都宮 健輔, 他
    • Organizer
      第29回日本生物学的精神医学会第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] DRD3受容体及びCYPIA2遺伝子多型の相互作用は統合失調症における病的多飲のリスク予測に有用な可能性がある2007

    • Author(s)
      坂田 深一, 他
    • Organizer
      第29回日本生物学的精神医学会第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Related Report
      2007 Annual Research Report
  • [Presentation] ドーパミンD1受容体(DRD1)遺伝子多型(-48A/G)と統合失調症における水中毒との関連について2007

    • Author(s)
      宇都宮 健輔, 他
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症における病的多飲とセロトニン2A受容体遺伝子多型(T102C)との関連2007

    • Author(s)
      坂田 深一, 他
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] TPH2遺伝子多型と統合失調症における病的多飲2007

    • Author(s)
      新開 隆弘, 他
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症とNeuropeptideY遺伝子プロモーター領域における機能的多型(・485C>T)との関連研究2007

    • Author(s)
      井上 賀晶, 他
    • Organizer
      第17回日本臨床精神神経薬理学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic association between the dopamine D1 receptor gene(DRD1)polymorphism(-48A/G)and polydipsia in schizophrenia2007

    • Author(s)
      K.Utsunomiya, et. al.
    • Organizer
      XV World Congress on Psychiatric Genetics
    • Place of Presentation
      New York,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] TPH2 polymorphisms and polydipsia in schizophrenia2007

    • Author(s)
      T.Shinkai, et. al.
    • Organizer
      XV World Congress on Psychigtric Genetics
    • Place of Presentation
      New York,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic association analysis between the HTR2A gene polymorphism(T102C)and polydipsia in schizophrenia2007

    • Author(s)
      S.Sakata, et. al.
    • Organizer
      XV World Congress on Psychiatric Genetics
    • Place of Presentation
      New York,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] No genetic association between the functional polymorphism in the promoter region of the neuropeptide Y gene and schizophrenia2007

    • Author(s)
      Y.Inoue, et. al.
    • Organizer
      XV World Congress on Psychiatric Genetics
    • Place of Presentation
      New York,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Association study between the C-1291G polymorphism in the promoter region of the adrenergic alpha 2A receptor gene and polydipsia in schizophrenia2007

    • Author(s)
      W.Yamaguchi, et. al.
    • Organizer
      XV World Congress on Psychiatric Genetics
    • Place of Presentation
      New York,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetics of polydipsia in schizophrenia2007

    • Author(s)
      T.Shinkai, et. al.
    • Organizer
      XV World Congress on Psychiatric Genetics
    • Place of Presentation
      New York,USA
    • Related Report
      2007 Annual Research Report
  • [Book] Tardive Dyskinesia, Molecular Mechanisms. In : Encyclopedia of Molecular Mechanisms of Disease, Florian Lang (Ed.)2009

    • Author(s)
      TAKAHIRO SHINKAI
    • Publisher
      Springer(in press)
    • Related Report
      2008 Final Research Report
  • [Book] Encyclopedia of Molecular Mechanisms of Disease2009

    • Author(s)
      Shirikai, Takahiro Lang, Florian (Ed. )
    • Total Pages
      2270
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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