Specific PET diagnosis and tailored radioisotope therapy of pancreatic cancer targeting L type amino acid transporter

• Project/Area Number: 18591329
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: HIGUCHI Tetsuya Gunma University, 大学院・医学系研究科, 助教 (60323367)
• Co-Investigator(Kenkyū-buntansha): ENDO Keigo 群馬大学, 大学院・医学系研究科, 教授 (10115800)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,920,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: FAMT / PET / 膵癌 / アミノ酸輸送担体(LAT1) / F-18標識αメチルタイロシン / ポジトロンCT / RI内用療法

Research Abstract

2年目までの検討で膵癌では糖代謝亢進によりFDG(F18フルオロデオキシグルコース)の集積は強いがRI標識アミノ酸であるFAMT(F18αメチルタイロシン)の集積は弱いことがわかり、研究のターゲットを頭頚部腫瘍、肺癌に変更し、ポジトロンCT検査(PET検査)でのFAMT(F-18標識αメチルタイロシン)集積と悪性度や増殖能、LAT1(L型アミノ酸輸送担体)発現の関連に関する研究行った。頭頚部腫瘍では、FAMT-PET/CTにて良悪性の鑑別が可能であることがわかった。一方、肺癌症例を対象にした研究では、36例の肺癌でのLAT1、CD98、Li-67、VEGF、CD31、CD34を評価に加えた免疫組織学的検討で、LAT1、CD98、増殖能、血管新生の因子が、FAMTの集積と最も関連しており、FAMT集積の高い症例では、一般に悪性度が高く転移のリスクも高いことが示された。

Research Products

• [Journal Article] Radioimmunotherapy of solid tumors targeting a cell-surface protein FZD10 : therapeutic efficacy largely depends on radiosensitivity (2009)
  • Author(s): Hanaoka H, Higuchi T
  • Journal Title: Ann Nucl Med 5
  • NAID: 10025136774
  • Peer Reviewed
• [Journal Article] Correlation of angiogenesis with (18)F-FMT and (18)F-FDG uptake in non-small cell lung cancer (2009)
  • Author(s): Kaira K, Oriuchi N, Shimizu K, Ishikita T, Higuchi T
  • Journal Title: Cancer Sci 1 ; 2009
  • NAID: 10025144864
  • Peer Reviewed
• [Journal Article] Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT : a clinicopathological study (2009)
  • Author(s): Kaira K, Higuchi T
  • Journal Title: Int J Cancer 1 ; 124(5) Pages: 1152-60
  • Peer Reviewed
• [Journal Article] Correlation of angiogenesis with (18)F-FMT and (18)F-FDG uptake in non-small cell lung cancer. (2009)
  • Author(s): Kaira K
  • Journal Title: Cancer Sci. (In press)
  • Peer Reviewed
• [Journal Article] Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT: a clinicopathological study. (2009)
  • Author(s): Kaira K
  • Journal Title: Int J Cancer. 124(5) Pages: 1152-6
  • Peer Reviewed
• [Journal Article] Detection of metastatic lesions from malignant pheochromocytoma and paraganglioma with diffusion-weighted magnetic resonance imaging : comparison with 18F-FDG positron emission tomography and 123I-MIBG scintigraphy (2008)
  • Author(s): Takano A, Higuchi T
  • Journal Title: Ann Nucl Med 22(5) Pages: 395-401
  • NAID: 10021281382
  • Peer Reviewed
• [Journal Article] Detection of metastatic lesions from malignant pheochro mocytoma and paraganglioma with diffusion-weighted magnetic resonance jmaging: comparison with 18F-FDG positron emission tomography and 123I-MIBG scintigraphy. (2008)
  • Author(s): Takano A
  • Journal Title: Ann Nucl Med. 22(5) Pages: 395-401
  • Peer Reviewed
• [Journal Article] Expression of glucose transporters and hexokinase II in cholangiocellular carcinoma compared using [18F]-2-fluro-2-deoxy-D-glucose positron emission tomography (2008)
  • Author(s): Paudyal B
  • Journal Title: Cancer Science 99 Pages: 260-266
  • Peer Reviewed
• [Journal Article] CIinicopathological presentation of varying 18F-FDG uptake and expression of glucose transporter 1 and hexokinase II in cases of hepatocellular carcinoma and cholangiocellular carcinoma (2008)
  • Author(s): Paudyal B
  • Journal Title: Ann Nucl Med 22 Pages: 83-86
  • Peer Reviewed
• [Journal Article] Diagnosis of maxillofacial tumor with L-3-[18f]-fluoro-alpha-methyltyrosine (FMT) PET : a comparative study with FDG-PET (2007)
  • Author(s): Miyakubo M, Higuchi T
  • Journal Title: Ann Nucl Med 21(2) Pages: 129-35
  • Peer Reviewed
• [Journal Article] Oncol Rep (2007)
  • Author(s): Paudyal B
  • Journal Title: Early diagnosis of recurrent hepatocellular carcinoma with 18F-FDG PET after radiofrequency ablation therapy 18 Pages: 1469-1473
  • Peer Reviewed
• [Journal Article] Diagnosis of maxillofacial tumor with L-3-[^<18>F]-fluoro-alpha-methyltyrosine (FMT) PET : a comparative study with FDG-PET. (2007)
  • Author(s): Miyakubo M
  • Journal Title: Annals of Nuclear Medicine 21・(2) Pages: 129-35
• [Journal Article] RI標識抗体による癌治療 (2007)
  • Author(s): 織内 昇
  • Journal Title: Biotherapy 21・(2) Pages: 137-144
• [Journal Article] Present role and future prospects of positron emission tomography in clinical oncology. (2006)
  • Author(s): Oriuchi N
  • Journal Title: Cancer Science 97・(12) Pages: 1291-7
• [Journal Article] PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients. (2006)
  • Author(s): Endo K
  • Journal Title: International Journal of clinical oncology 11・(4) Pages: 286-96
  • NAID: 10018768760
• [Presentation] Clinical usefulness of FDG-PET/CT in the evaluation of Langerhans cell histiocytosis occurred in pelvic bone (2008)
  • Author(s): Higuchi T
  • Organizer: Annual meeting of the European association of nuclear medicine
  • Place of Presentation: ミュンヘン・ドイツ
  • Year and Date: 2008-10-12
• [Presentation] Comparative study of FDG-PET and I-123 MIBG scan in the evaluation of therapeutic effect of malignant pheochromocytoma treated by I-131 MIBG therapy (2007)
  • Author(s): Higuchi T
  • Organizer: Annual meeting of the European association of nuclear medicine
  • Place of Presentation: コペンハーゲン、デンマーク
  • Year and Date: 2007-10-15