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The clinical research and development of non-invasive metabolic and perfusion imaging on 3T MR

Research Project

Project/Area Number 18591335
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Fukui

Principal Investigator

KIMURA Hirohiko  University of Fukui, 医学部, 教授 (10242596)

Co-Investigator(Kenkyū-buntansha) UEMATSU Hidemasa  福井大学, 医学部, 講師 (00313768)
TSUCHIDA Tatsuro  福井大学, 医学部附属病院, 講師 (70303386)
TOYOOKA Mariko  福井大学, 医学部附属病院, 助教 (00397275)
TAMAGAWA Youichi  福井大学, 工学研究科, 准教授 (40236732)
ISHIMORI Yoshiyuki  茨城県立医療大学, 保健医療学部, 講師 (30401970)
Co-Investigator(Renkei-kenkyūsha) TAMAGAWA Youichi  福井大学, 工学研究科, 准教授 (40236732)
ISHIMORI Yoshiyuki  茨城県立医療大学, 保健医療学部, 講師 (30401970)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsMR / Perfusion / MRS / CASL / 脳血管障害 / ASL / MR Perfusion / スピンラベル / GABA / MEGA-PRESS / spin label / MRI / perfusion
Research Abstract

Continuous ASL法の中核となるラベル法の問題点を解決し、そのS/Nと信頼性の向上を3TMRI上にて得ることができた。慢性閉塞性脳血管患者を対象として、PETによる脳血流値とピクセル毎に比較することで、その定量性の観点から本手法の妥当性を証明した。

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (3 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images2010

    • Author(s)
      T. Tsujikawa, M. Yoneda, Y. Shimizu, H. Uematsu, M. Toyooka, M. Ikawa, T. Kudo, H. Okazawa, M. Kuriyama, H. Kimura
    • Journal Title

      Brain Dev 32(2)

      Pages: 143-149

    • NAID

      10027213011

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3T-MRIによる脳腫瘍の血流評価2009

    • Author(s)
      山元龍哉, 木村浩彦
    • Journal Title

      日獨医報 54(3-4)

      Pages: 270-282

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] PET imaging of redox and energy states in stroke-like episodes of MELAS2009

    • Author(s)
      S. Ikawa, H. Okazawa, K. Arakawa, T. Kudo, H. Kimura, Y. Fujibayashi, M. Kuriyama, M. Yoneda
    • Journal Title

      Mitochondrion 9(2)

      Pages: 144-148

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arterial Spin Labeling (ASL)による脳血流計測:スピン到達時間の補正についての試み2009

    • Author(s)
      H. Kimura, Y. Arai, H. Okazawa
    • Journal Title

      脳循環代謝 20(2)

      Pages: 52-56

    • Related Report
      2009 Final Research Report
  • [Journal Article] Evaluation of required saline volume in dynamic contrast-enhanced computed tomography using saline flush technique2009

    • Author(s)
      Isao Yamaguchi, Eiji Kidoya, Masayuki Suzuki, Hirohiko Kimura
    • Journal Title

      Computerized Medical Imaging and Graphics 33(1)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arterial Spin Labeling(ASL)による脳血管障害の血流検査2009

    • Author(s)
      木村浩彦
    • Journal Title

      分子脳血管病 8(2)

      Pages: 65-71

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Operation of bolus traking system for prediction of aortic peak enhancement at multidetector row computed tomography2008

    • Author(s)
      Isao Yamaguchi, Hiroyuki Hayashi, Masayuki Suzuki, Katsuhiro Ichikawa, Eiji Kidoya, Hirohiko Kimura
    • Journal Title

      Radiation Medicine 26(5)

      Pages: 278-286

    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 18F-FDG PET of common enhancing malignant brain tumors2008

    • Author(s)
      N. Kosaka, T. Tsuchida, H. Uematsu, H. Kimura, H. Okazawa, H. Itoh
    • Journal Title

      190(6)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue characterization of glioma by proton MR spectroscopy and perfusion-weighted MR imaging. glioma grading and histological correlation2008

    • Author(s)
      Mariko Toyooka, Hirohiko Kimura, Hidemasa Uematsu, Yasutaka Kawamura, Hiroaki Takeuchi, Harumi Itoh
    • Journal Title

      Clinical Imaging 32(4)

      Pages: 251-258

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臨床MRSの基礎と応用2008

    • Author(s)
      木村浩彦, 豊岡麻理子
    • Journal Title

      日本磁気共鳴医学会雑誌 28(4)

      Pages: 263-272

    • NAID

      10026917049

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tissue characterization of glioma by proton MR spectroscopy and perfusion-weighted MR imaging: glioma grading and histological correlation2008

    • Author(s)
      Mariko Toyooka, Hirohiko Kimura, Hidemasa Uematsu, Yasutaka Kawamura, Hiroaki Takeuchi, Harumi Itoh
    • Journal Title

      Clinical Imaging

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 臨床MRS の基礎と応用2008

    • Author(s)
      木村浩彦, 豊岡麻理子
    • Journal Title

      日本磁気共鳴医学会雑誌 28(4)

      Pages: 263-272

    • NAID

      10026917049

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Tissue characterization of glioma by proton MR spectros copy and perfusion-weighted MR imaging : glioma grading and histological correlation2008

    • Author(s)
      M. Toyooka
    • Journal Title

      Clinical Imaging 32(4)

      Pages: 251-258

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Operation of bolus traking system for prediction of aortic peak enhancement at multidetector row computed torn ography2008

    • Author(s)
      I. Yamaguchi
    • Journal Title

      Radiation Medicine 26(5)

      Pages: 278-286

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床MRSの基礎と応用2008

    • Author(s)
      木村浩彦
    • Journal Title

      日本磁気共鳴医学会雑誌 28(4)

      Pages: 263-272

    • NAID

      10026917049

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASLパーフュージョンイメージングの最新報告:臨床応用を目指した演題を中心に2007

    • Author(s)
      木村浩彦
    • Journal Title

      VIEWS RADIOLOGY 9(5)

      Pages: 16-23

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Journal Article] ASLパーフュージョンイメージ ングの最新報告 : 臨床応用を目指した演題を中心に2007

    • Author(s)
      木村浩彦
    • Journal Title

      VIEWS RADIOLOGY 9(5)

      Pages: 16-23

    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease Using 3D Spiral SE Arterial Spin Labeling on 3T-MR2009

    • Author(s)
      Kimura Hirohiko, Okazawa Hidehiko, Matsuda Tsuyoshi, Arai Yoshikazu, Shankaranarayanan Asit, Alsop David D
    • Organizer
      Correlative Study with O15 Labeled H2O PET Examination. ISMRM 2009
    • Place of Presentation
      Hawai
    • Related Report
      2009 Final Research Report
  • [Presentation] Cerebral Blood Flow and Arterial Transit Time Measurements in Patients with Chronic Occlusive Cerebrovascular Disease using 3D spiral SE Arterial Spin Labeling on 3T-MR : Correlative Study with O^<15> labeled H_2O PET Examination2009

    • Author(s)
      H.Kimura, H.Okazawa, T.Matsuda, Y.Arai, A.Shankaranarayanan, D.Alsop
    • Organizer
      ISMRM 2009
    • Place of Presentation
      Hawai
    • Related Report
      2009 Annual Research Report
  • [Presentation] Continuous arterial spin labeling法による脳血流測定法:PET dataとの全脳領域でのpixel単位での企画2008

    • Author(s)
      木村浩彦, 豊岡麻理子, 土田龍郎, 岡沢秀彦, 新井良和
    • Organizer
      第20回臨床MR脳機能研究会
    • Place of Presentation
      東京都
    • Year and Date
      2008-03-15
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 造影剤を用いない脳血流測定法CASL(Continuous Arterial Spin Labeling)の理論と臨床応用2008

    • Author(s)
      木村浩彦
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京都
    • Related Report
      2009 Final Research Report
  • [Presentation] スピン到達時間の補正をしたASL法による定量的血流画像:PET dataとの全脳領域でのpixel単位での比較2008

    • Author(s)
      木村浩彦, 豊岡麻理子, 土田龍郎, 岡沢秀彦, 新井良和, 椛沢宏之, 松田豪
    • Organizer
      第36回日本磁気共鳴医学会大会
    • Place of Presentation
      旭川市
    • Related Report
      2009 Final Research Report
  • [Presentation] 造影剤を用いない脳血流測定法CASL(Continuous Arterial Spin Labeling)の理論と臨床応用2008

    • Author(s)
      木村浩彦
    • Organizer
      第20 回日本脳循環代謝学会総会(MR 画像の進歩-どこまでできるか-)
    • Place of Presentation
      東京都
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Continuous arterial spin labeling 法による脳血流測定法 : PET dataとの全脳領域でのpixel 単位での企画2008

    • Author(s)
      木村浩彦, 豊岡麻理子, 土田龍郎, 岡沢秀彦, 新井良和
    • Organizer
      第20回臨床MR 脳機能研究会
    • Place of Presentation
      東京都
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 造影剤を用いない脳血流測定法CASL(Continuous Arterial Spin Labeling)の理論と臨床応用2008

    • Author(s)
      木村浩彦
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Perfusion imaging of glioma using continuous arterial spin labeling (CASL): Comparison with histopathological features2007

    • Author(s)
      H. Kimura, H. Takeuchi, H. Kabaswa, M. Toyooka, N. Kosaka, H. Uematsu, H. Itoh
    • Organizer
      Joint annual meeting of ISMRM and ESMRMB Proceedings
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] A new ASL scheme of repeated labeling based on FAIR sequence2007

    • Author(s)
      Y. Fujiwara, H. Kimura, H. Kabasawa, Y. Ishimori, I. Yamaguchi, T. Miyati, K. Higashimura, H. Itoh
    • Organizer
      Joint annual meeting of ISMRM and ESMRMB, Proceedings
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
  • [Presentation] Perfusion imaging of glioma using continuous arterial spin labeling (CASL) : Comparison with histopathological features2007

    • Author(s)
      H.Kimura, H.Takeuchi, H.Kabaswa, M.Toyookal, N.Kosaka, H.Uematsu, H.Itoh
    • Organizer
      Joint annual meeting of ISMRM and ESMRMB Proceedings
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Perfusion imaging of glioma using continuous arterial spin labeling(CASL): Comparison with histopathological features.2007

    • Author(s)
      H. Kimura, H. Takeuchi, H. Kabaswa, M. Toyookal, N. Kosakal, H. Uematsu, and H. Itoh
    • Organizer
      Joint annual meeting of ISMRM and ESMRMB, Proceedings
    • Place of Presentation
      Berlin, Germany.
    • Related Report
      2007 Annual Research Report
  • [Presentation] A new ASL scheme of repeated labeling based on FAIR sequence.2007

    • Author(s)
      Y. Fujiwara, H. Kimura, H. Kabasawa, Y. Ishimori, I. Yamaguchi, T. Miyati, K. Higashimura, and H. Itoh
    • Organizer
      Joint annual meeting of ISMRM and ESMRMB, Proceedings
    • Place of Presentation
      Berlin, Germany.
    • Related Report
      2007 Annual Research Report
  • [Book] 脳神経外科アドバンス(MRI:診断と治療社)2008

    • Author(s)
      木村浩彦
    • Related Report
      2009 Final Research Report
  • [Book] 脳神経外科アドバンス2008

    • Author(s)
      木村浩彦(分担)
    • Publisher
      MRI : 診断と治療社
    • Related Report
      2008 Self-evaluation Report
  • [Book] 脳神経外科アドバンス2008

    • Author(s)
      分担 : 木村浩彦
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] MEGA PRESS法を用いたGABA,Glu, Glnの定量方2008

    • Inventor(s)
      松田豪, 木村浩彦
    • Industrial Property Rights Holder
      GE横河メディカルシステム(株)
    • Industrial Property Number
      2008-146664
    • Filing Date
      2008-06-04
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] MEGA PRESS 法を用いたGABA,Glu,Gln の定量方2008

    • Inventor(s)
      松田豪, 木村浩彦
    • Industrial Property Rights Holder
      GE 横河メディカルシステム(株)
    • Industrial Property Number
      2008-146664
    • Filing Date
      2008-06-04
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] MEGA PRESS法を用いたGABA, Glu, Ginの定量方2008

    • Inventor(s)
      松田豪, 木村浩彦
    • Industrial Property Rights Holder
      GE横河メディカルシステム(株)
    • Industrial Property Number
      2008-146664
    • Filing Date
      2008-06-04
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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