| Project/Area Number |
18591337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gifu University |
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Principal Investigator |
KANEMATSU Masayuki Gifu University, University Hospital, associate professor (40252134)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Hiroshi Gifu University, University Hospital, lecturer (20324311)
COSHIMA Satoshi Gifu University, University Hospital, Assistant Professor (90402205)
TAKAI Kouji Gifu University, University Hospital, Clinical Fellow (70402196)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥1,720,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥120,000)
Fiscal Year 2007: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Liver / Cirrhosis / MR imaging / Perfusion / hepatic blood flow / 肝血流 / 肝機能 / 肝予備能 / ナビゲータ補正 / 三次元撮像 / ガドリニウム / 3Dシーケンス |
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| Research Abstract |
We performed perfusion analysis of the liver after giving 5-mL gadolinium-chelate contrast material. After obtaining conventional dynamic. MR imaging of the liver, single-level cine. MR imaging was performed with 5-mL gadolinium contrast for perfusion analysis with dual-input-one-compartment model. We obtained hepatic blood flow ; hepatic, blood volume, mean transit time, and arterial-portal fraction. We evaluated if preceding dynamic MR imaging did not hamper the efficacy of subsequent perfusion imaging. We used algorithm of dual-input one-compartment model (Materne R, et. al. Magn Reson Med 2002 ; 47:135) for perfusion analysis. Several parameters derived from the analysis were correlated with clinical stages of chronic liver damage or cirrhosis, pathological stage of hepatic fibrosis, Child-Pugh score, and ICG15 test value. We found that our methodology for MR perfusion nalysis reflected the degree of hepatic fibrosis to a certain extent. We still need to solve some problems in the technical aspects to increase the accuracy of this technique.
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