Research of incorporation of hepatic perfusion analysis using bigh-spatialresolution MRimaging

• Project/Area Number: 18591337
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Gifu University
• Principal Investigator: KANEMATSU Masayuki Gifu University, University Hospital, associate professor (40252134)
• Co-Investigator(Kenkyū-buntansha): KONDO Hiroshi Gifu University, University Hospital, lecturer (20324311) ; COSHIMA Satoshi Gifu University, University Hospital, Assistant Professor (90402205) ; TAKAI Kouji Gifu University, University Hospital, Clinical Fellow (70402196)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥1,720,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥120,000); Fiscal Year 2007: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: Liver / Cirrhosis / MR imaging / Perfusion / hepatic blood flow / 肝血流 / 肝機能 / 肝予備能 / ナビゲータ補正 / 三次元撮像 / ガドリニウム / 3Dシーケンス

Research Abstract

We performed perfusion analysis of the liver after giving 5-mL gadolinium-chelate contrast material. After obtaining conventional dynamic. MR imaging of the liver, single-level cine. MR imaging was performed with 5-mL gadolinium contrast for perfusion analysis with dual-input-one-compartment model. We obtained hepatic blood flow ; hepatic, blood volume, mean transit time, and arterial-portal fraction. We evaluated if preceding dynamic MR imaging did not hamper the efficacy of subsequent perfusion imaging. We used algorithm of dual-input one-compartment model (Materne R, et. al. Magn Reson Med 2002 ; 47:135) for perfusion analysis. Several parameters derived from the analysis were correlated with clinical stages of chronic liver damage or cirrhosis, pathological stage of hepatic fibrosis, Child-Pugh score, and ICG15 test value. We found that our methodology for MR perfusion nalysis reflected the degree of hepatic fibrosis to a certain extent. We still need to solve some problems in the technical aspects to increase the accuracy of this technique.

Research Products

• [Journal Article] Computer-aided diagnosis of hepatic fibrosis: preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network. (2007)
  • Author(s): Kato H, Kanematsu M, Zhang X, Saio M, Kondo H, Goshima S, Fujita H.
  • Journal Title: Am J Roentgenol 189 Pages: 117-122
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction: phantom study and preliminary clinical evaluation. (2007)
  • Author(s): Kanematsu M, Goshima S, Kon do H, Tsuge Y, Yokoyama R, Kajita K, Onozuka M, Suzuki Y, Van Cauteren M, Moriyama N.
  • Journal Title: Am J Roentgenol 188 Pages: 309-316
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Computer-aided diagnosis of hepatic fibrosis : preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network (2007)
  • Author(s): Kato, H., Kanematsu, M., Zhang, X., Saio, M., Kondo, H., Goshima, S., Fujita, H
  • Journal Title: Am J Roentgenol 189(1) Pages: 117-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction : phantom study and preliminary clinical evaluation (2007)
  • Author(s): Kanematsu, M., Goshima, S., Kondo, H., Tsuge, Y., Yokoyama, R., Ralik, K., Onozuka, M., Suzuki, Y., Van, Cautcrcn, M., Moriyama, N
  • Journal Title: Am J Roentgenol 188(4) Pages: 309-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction: phantom study and preliminary clinical evaluation. (2007)
  • Author(s): Kanematsu M, Goshima S, Kondo H, Tsuge Y, Yokoyama R, Kajita K, Onozuka M, Suzuki Y, Van Cauteren M, Moriyama N.
  • Journal Title: Am J Roentgenol 188 Pages: 309-316
  • Peer Reviewed
• [Journal Article] Classification of cirrhotic liver in gadolinium-enhanced MR images (2007)
  • Author(s): Lee G, Uchiyama Y, Zhang X, Kanematsu M, Zhou X, Hara T, Kato H, Kondo H, Fujita H, Hoshi H.
  • Journal Title: Computer-Aided Diagnosi 6514
  • Peer Reviewed
• [Journal Article] MDCT of the pancreas : optimizing scanning delay with a bolus-tracking technique for pancreatic, peripancreatic vascular, and hepatic contrast enhancement. (2007)
  • Author(s): Kondo H, Kaanematsu M, Goshima S, Miyoshi T, Shiratori Y, Onozuka M, Moriyama N, Bae KT.
  • Journal Title: Am J Roentgenol 188 Pages: 751-756
• [Journal Article] Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K-space reordering. (2006)
  • Author(s): Kanematsu M, Goshima S, Kondo H, Yokoyama R, Kajita K, II oshi H, Onozuka M, Nozaki A, Hirano M, Shiratori Y, Moriyama N.
  • Journal Title: Am J Roentgenol 187 Pages: 25-32
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K-space reordering (2006)
  • Author(s): Kanematsu, M., Goshima, S., Kondo, II., Yokoyama, R., Kajita, K., IIoshi, II., Onozuka, M., Nozaki, A., Hirano, M., Shiratori, Y., Moriyama, N
  • Journal Title: Am J Romilgenol 187(2) Pages: 464-472
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Double hepatic artcrial phase MRI of the liver with switching of reversed centric and centric K-space reordering. (2006)
  • Author(s): Kanematsu M, Goshima S, Kondo H, Yokoyama R, Kajita K, Hoshi H, Onozuka M, Nozaki A, IIirano M, Shiratori Y, Moriyama N.
  • Journal Title: Am J Roentgenol 187 Pages: 464-472
• [Journal Article] Pancreas : Optimal Scan Delay for Contrast-enhanced Multi-Detector Row CT. (2006)
  • Author(s): Goshima S, Kanematsu M, Kondo H, Yokoyama R, Miyoshi T, Kato H, Tsuge Y, Shiratori Y, Hoshi H, Onozuka M, Moriyama N, Bae KT.
  • Journal Title: Radiology 241 Pages: 167-174
• [Journal Article] MDCT of the liver and hypervascular hepatocellular carcinomas : optimizing scan delays for bolus-tracking techniques of hepatic arterial and portal venous phases. (2006)
  • Author(s): Goshima S, Kanematsu M, Kondo H, Yokoyama R, Miyoshi T, Nishibori H, Kato H, Hoshi H, Onozuka M, Moriyama N.
  • Journal Title: Am I Roentgenol 187 Pages: 25-32
• [Journal Article] Imaging liver metastases : Review and update. (2006)
  • Author(s): Kanematsu M, Kondo H, Goshima S, Kato H, Tsuge U, Hirose Y, Kim MJ, Moriyama N.
  • Journal Title: Eur J Radiol 58 Pages: 217-228
• [Journal Article] Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver : correlation with MR imaging and angiographically assisted CT. (2006)
  • Author(s): Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Moriyama N
  • Journal Title: Abdom Imaging 31 Pages: 78-89
• [Presentation] Gadolinium-enhanced Three-dimensional MR Imaging of the Liver: Optimizing Imaging Delay for Early, Late Hepatic Arterial, and Portal Venous Phases in the Detection of Hypervascular Hepatocellular Carcinomas. (2007)
  • Author(s): Watanabe H, Goshima S, Kondo H, Tsuge Y, Yokoyama R, Kanematsu M.
  • Organizer: 第93回北米放射線学会
  • Place of Presentation: 米国,シカゴ
  • Year and Date: 2007-12-01
• [Presentation] Diffusion-weighted MRI of the Hepatic Hemangioma: Relationships between Enhancement Types and Apparent Diffusion Coefficients. (2006)
  • Author(s): Goshima S, Kanematsu M, Kondo H, Tsuge U
  • Organizer: 第92回北米放射線学会
  • Place of Presentation: シカゴ,米国
  • Year and Date: 2006-12-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diffusion Weighted MRI of the Hepatie Hemangioma : Relationships between Enhancement Typcs and Apparcnt Diffusion Cocfficicnts (2006)
  • Author(s): Goshima, S., Kanematsu, M., Kondo, H., Tsuge, U
  • Organizer: 92th Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2006-12-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Advances in obstructive jaundice.Diagnosis and treatment. 1st ed. (2007)
  • Author(s): Leonardou P, Pappas P, Kanematsu M.
  • Publisher: Paschalidis Medical Publications, Ltd(分担)