Relationship between metabolic disorder and viability in damaged myocardium : assessment with nuclear cardiology and magnetic resonance imaging
Project/Area Number |
18591339
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Mie University |
Principal Investigator |
KAN Takeda Mie University, 大学院・医学系研究科, 教授 (70106988)
|
Co-Investigator(Kenkyū-buntansha) |
HAJIME Sakuma 三重大学, 医学部附属病院, 准教授 (60205797)
NAOHISA Suzawa 三重大学, 医学部附属病院, 医員 (80378372)
|
Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥3,960,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
Keywords | 心筋虚血 / 心筋脂肪酸代謝 / 心筋糖代謝 / 心筋血流 / 虚血性心疾患 / 遅延造影MRI / N-13アンモニアPET / F-18 FDG PET / 心筋バイアビリティ / FDG PET / 心臓MRI |
Research Abstract |
虚血や薬剤などによる心筋障害を、I-123BMIPPダイナミックSPECT による脂肪酸代謝、FDG-PET による糖代謝、N-13 アンモニアPETによる心筋血流検査、遅延造影MRIによる心筋壊死・線維化の評価などを用いて総合的に検討した。LSO を使用したPET-CT装置は感度とカウントの直線性に優れ、短時間で正確な心筋血流と心筋代謝の計測が可能であった。MRI による梗塞心筋の組織性状に関する情報と核医学による血流・代謝の情報を組み合わせることにより、心筋障害の病態をより正確に評価できる。
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Report
(4 results)
Research Products
(20 results)
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[Presentation] Subendmyocardial Perfusion Reserve Correlated with Left Ventricular Diastolic Function in Patients with Various Types of Left Ventricular Hypertrophy2008
Author(s)
Kurita T, Onishi K, Sakuma H, Takamura T, Nagata M, Nakajima H, Ishida M, Fujimoto N, Dohi K, Takeda K, Ito M.
Organizer
AHA scientific sessions2008
Place of Presentation
New Orleans
Related Report
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[Presentation] Rest and stress myocardial blood flow (MBF) measured by fully quantitative analysis of first-pass perfusion MRI showed good agreement with rest and stress MBF by radio-water PET2007
Author(s)
Ishida M, Sakuma H, Nagata M,Ishida N, Mikami Y, Ichihara T, Maeda H,Goko Y, Parkka J, Kunuuti J, Haltiala J, Takeda K.
Organizer
92th RSNA
Place of Presentation
Chicago
Related Report
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[Presentation] Myocardial Perfusion Reserve Determined by Model Based Quantitative Analysis of Stress-Rest Perfusion MRI Permits Improved Accuracy in Predicting Coronary Artery Diseases When Compared with Semiquantitative Analysis2007
Author(s)
Ishida M, Sakuma H, Shi Y, Nagata M, Ishida N, Mikami Y, Ichihara T, Maeda H, Goko Y, Kurita T, Ito M, Takeda K
Organizer
AHA scientific sessions 2007
Place of Presentation
Orlando
Related Report
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[Presentation] Comparison between Radio-water PET and Model Based Quantitative Analysis of Myocardial Perfusion Magnetic Resonance2007
Author(s)
Ishida M, Parkka JP, Sakuma H, Nagata M, Ishida N, Mikami Y, Ichihara T, Takeda K, Maeda H, Goko Y, Kunuuti J, Hartiala JJ
Organizer
AHA scientific sessions 2007
Place of Presentation
Orlando
Related Report
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[Presentation] Absolute Quantification of Myocardial Blood Flow Using First-Pass Perfusion MRI : Extraction Fraction of Gd-DTPA Varies with Myocardial Blood Flow in Human Myocardium2007
Author(s)
Ishida M, Sakuma H, Ichihara T, Goko Y, Ishida N, Nagata M, Kitagawa K, Maeda H, Kurita T, Teraoka K, Takeda K
Organizer
15th ISMRM
Place of Presentation
Berlin
Related Report