Relationship between metabolic disorder and viability in damaged myocardium : assessment with nuclear cardiology and magnetic resonance imaging

• Project/Area Number: 18591339
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: KAN Takeda Mie University, 大学院・医学系研究科, 教授 (70106988)
• Co-Investigator(Kenkyū-buntansha): HAJIME Sakuma 三重大学, 医学部附属病院, 准教授 (60205797) ; NAOHISA Suzawa 三重大学, 医学部附属病院, 医員 (80378372)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,960,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 心筋虚血 / 心筋脂肪酸代謝 / 心筋糖代謝 / 心筋血流 / 虚血性心疾患 / 遅延造影MRI / N-13アンモニアPET / F-18 FDG PET / 心筋バイアビリティ / FDG PET / 心臓MRI

Research Abstract

虚血や薬剤などによる心筋障害を、I-123BMIPPダイナミックSPECT による脂肪酸代謝、FDG-PET による糖代謝、N-13 アンモニアPETによる心筋血流検査、遅延造影MRIによる心筋壊死・線維化の評価などを用いて総合的に検討した。LSO を使用したPET-CT装置は感度とカウントの直線性に優れ、短時間で正確な心筋血流と心筋代謝の計測が可能であった。MRI による梗塞心筋の組織性状に関する情報と核医学による血流・代謝の情報を組み合わせることにより、心筋障害の病態をより正確に評価できる。

Research Products

• [Journal Article] Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire (2009)
  • Author(s): Kurita T, Sakuma H, Onishi K, Ishida M, Kitagawa K, Yamanaka T, Tanigawa T, Kitamura T, Takeda K, Ito M
  • Journal Title: Eur Heart J. 30 Pages: 444-452
  • Peer Reviewed
• [Journal Article] Absolute blood contrast concentration and blood signal saturation on myocardial perfusion MRI : estimation from CT data (2009)
  • Author(s): shida M, Sakuma H, Murashima S, Nishida J, Senga M, Kobayasi S, Takeda K, Kato N
  • Journal Title: J Magn Reson Imaging 29 Pages: 205-210
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : a multicenter study (2008)
  • Author(s): Kitagawa K, Sakuma H, Nagata M, Okuda S, Hirano M, Tanimoto A, Matsusako M, Lima JA, Kuribayashi S, Takeda K.
  • Journal Title: Eur Radiol 18 Pages: 2808-2816
  • Peer Reviewed
• [Journal Article] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging (2008)
  • Author(s): Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H.
  • Journal Title: Circ J 72 Pages: 378-383
  • NAID: 110006646489
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of stress myocardial perfusion MRI and late gadolinium-enhanced MRI for detecting flow-limiting coronary artery disease : a multicenter study. (2008)
  • Author(s): Kitagawa K, Sakuma H, Nagata M, Okuda S, Hirano M, Tanimoto A, Matsusako M, Lima JA, Kuribayashi S, Takeda K.
  • Journal Title: Eur Radiol. 18 Pages: 2808-2816
  • Peer Reviewed
• [Journal Article] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomvopathy assessed by magnetic resonance imaging. (2008)
  • Author(s): Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H.
  • Journal Title: Circ J. 72 Pages: 378-383
  • Peer Reviewed
• [Journal Article] Quantitative analysis of first-pass contrast-enhanced myocardial perfusion MRI using a patlak plot method and blood saturation correction (2007)
  • Author(s): Ichihara T, Ishida M, Kitagawa K, Ichikawa Y, atsume T, Yamaki N, Maeda H, Takeda K, Sakuma H
  • Journal Title: Magn Reson Med (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Diagnostic value of late gadolinium-enhanced MRI and first-pass dynamic MRI for predicting functional recovery in patients after acute myocardial infarction (2007)
  • Author(s): Kitagawa K, Ichikawa Y, Hirano T, Makino K, Kobayashi S, Takeda K, Sakuma H.
  • Journal Title: Radiat Med 25 Pages: 263-271
  • NAID: 10019726666
  • Peer Reviewed
• [Presentation] Quantification of Rest and Stress Myocardial Blood Flow with Prospectively Gated Dynamic Multi-slice CT : Comparison with 13N-ammonium Myocardial Perfusion PET (2008)
  • Author(s): Ishida M, Sakuma H, Nagata M, Ishida N, Ichihara T, Nakajima H, Ito M, Takeda K.
  • Organizer: 93th RSNA
  • Place of Presentation: Chicago
• [Presentation] Subendmyocardial Perfusion Reserve Correlated with Left Ventricular Diastolic Function in Patients with Various Types of Left Ventricular Hypertrophy (2008)
  • Author(s): Kurita T, Onishi K, Sakuma H, Takamura T, Nagata M, Nakajima H, Ishida M, Fujimoto N, Dohi K, Takeda K, Ito M.
  • Organizer: AHA scientific sessions2008
  • Place of Presentation: New Orleans
• [Presentation] Adenosine-stress CT Myocardial Perfusion Imaging : Comparison with Stress Myocardial Perfusion MRI in Patients with Coronary Artery Disease (2008)
  • Author(s): Ishida M, Sakuma H, Kato S, Nagata M, Ishida N, Nakamura M, Nakajima H, Ito M, Takeda K.
  • Organizer: AHA scientific sessions 2008
  • Place of Presentation: New Orleans
• [Presentation] Absolute quantification of myocardial blood flow from rest perfusion MRI can provide improved sensitivity for predicting myocardial viability in patients early after myocardial infarction (2008)
  • Author(s): Nagata M, Sakuma H, Kurita T, Ishida N, Ishida M, Mikami Y, Nakajima H, Ito M, Takeda K.
  • Organizer: ECR
  • Place of Presentation: Vienna, Austria
• [Presentation] Quantification of Rest and Stress Myocardial Blood Flow with Prospectively Gated Dynamic Multi-slice CT : Comparison with 13N-ammonium Myocardial Perfusion PET. (2008)
  • Author(s): Ishida M, Sakuma H, Nagata M, Ishida N, Ichihara T, Nakajima H, Ito M, Takeda K
  • Organizer: 第93回北米放射線学会
  • Place of Presentation: Chicago
• [Presentation] Rest and stress myocardial blood flow (MBF) measured by fully quantitative analysis of first-pass perfusion MRI showed good agreement with rest and stress MBF by radio-water PET (2007)
  • Author(s): Ishida M, Sakuma H, Nagata M,Ishida N, Mikami Y, Ichihara T, Maeda H,Goko Y, Parkka J, Kunuuti J, Haltiala J, Takeda K.
  • Organizer: 92th RSNA
  • Place of Presentation: Chicago
• [Presentation] Long Term Prognostic Value of Stress Perfusion CMR and Late Gadolinium Enhanced CMR for The Prediction of Major Adverse Cardiac Events (2007)
  • Author(s): Kurita T, Sakuma H, Onishi K, Nagata M, Takamura T, Ishida M, Fujimoto N, Dohi k, Takeda K, Ito M.
  • Organizer: AHA scientific sessions 2007
  • Place of Presentation: Orlando
• [Presentation] Absolute Quantification of Rest Myocardial Blood Flow by Cardiac Magnetic Resonance can provide Improved Prediction of Functional Recovery in Patients with Acute Myocardial Infarction (2007)
  • Author(s): Kurita T, Sakuma H, Nagata M, Ishida M, Tanigawa T, Onishi K, Isaka N, Takeda K, Ito M
  • Organizer: AHA scientific sessions 2007
  • Place of Presentation: Orlando
• [Presentation] Myocardial Perfusion Reserve Determined by Model Based Quantitative Analysis of Stress-Rest Perfusion MRI Permits Improved Accuracy in Predicting Coronary Artery Diseases When Compared with Semiquantitative Analysis (2007)
  • Author(s): Ishida M, Sakuma H, Shi Y, Nagata M, Ishida N, Mikami Y, Ichihara T, Maeda H, Goko Y, Kurita T, Ito M, Takeda K
  • Organizer: AHA scientific sessions 2007
  • Place of Presentation: Orlando
• [Presentation] Comparison between Radio-water PET and Model Based Quantitative Analysis of Myocardial Perfusion Magnetic Resonance (2007)
  • Author(s): Ishida M, Parkka JP, Sakuma H, Nagata M, Ishida N, Mikami Y, Ichihara T, Takeda K, Maeda H, Goko Y, Kunuuti J, Hartiala JJ
  • Organizer: AHA scientific sessions 2007
  • Place of Presentation: Orlando
• [Presentation] Absolute quantification of myocardial blood flow in patients with acute myocardial infarction after successful percutaneous coronary interventions (2007)
  • Author(s): Nagata M, Sakuma H, Ishida M, Kurita T, Ishida N, Tanigawa T, Onishi K, Ichihara T, Ito M, Takeda K
  • Organizer: 15th ISMRM
  • Place of Presentation: Berlin
• [Presentation] Absolute Quantification of Myocardial Blood Flow Using First-Pass Perfusion MRI : Extraction Fraction of Gd-DTPA Varies with Myocardial Blood Flow in Human Myocardium (2007)
  • Author(s): Ishida M, Sakuma H, Ichihara T, Goko Y, Ishida N, Nagata M, Kitagawa K, Maeda H, Kurita T, Teraoka K, Takeda K
  • Organizer: 15th ISMRM
  • Place of Presentation: Berlin