Conelation between degree of differentiation of hepatocellular carcinoma and signal intensity of diffusion-weigted images on 3T MR imaging

• Project/Area Number: 18591341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MAETANI Youji Kyoto University, Graduate School of Medicine, Assistant Professor (30324619)
• Co-Investigator(Kenkyū-buntansha): UEDA Mikiko Kyoto Univ, Graduate School of Medicine, Lecturer (20322159) ; HAGA Hironori Kyoto Univ, Graduate School of Medicine, Assistant Professor (10252462)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,950,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: Hepatocellular carcinoma / degree of differentiation / MR imaging / diffusion weighted images / 予後 / 3T超高磁場MRI

Research Abstract

Background: The degree of differentiation of hepatocellular carcinoma (HCC) is reported one of the most important factor that affect the prognosis of patients. Especially, in liver transplantation, the prognosis is reported very poor in patients with poorly-differentiated HCC Therefor, it is very important to speculate the degree of differentiation of HCC preoperatively by radiological technique. Very recently, there a few reports that there may be certain correlation between degree of differentiation of HCC and signal intensity of diffusion-weighted images of MR imaging. In addition, 3T MR imaging can become available in the upper abdominal region recently.
Purpose: To investigate if there is correlation between degree of diffirentiation of HCC and signal intensity of diffusiorr weighted images of 3T MR imaging.
Material and Methods: From 2007.5.11 to 2008.3.20, consecutive 52 patients who underwent hepatectomy or liver transplantation for HCC. The mean age was 57.3 years old. Respiratory triggered diffusion weighted images was performed based on the EM sequence. The scan parameters were as follows: TE=71, b value=0.500.1000. SENSE (turbo factor =2). The signal intensity was evaluated quantitatively in a 5-poiny scale by the consensus of three radiologists. Pathological analysis was performed by one liver pathologist and divided into well, moderate, poorly differentiated HCC. Statistical analysis was underwent Spearman rank correlation.
Results: Them was a good correlation between degree of differentiation of HCC and signal intensity of diffusion-weighted images of MR imaging with the "r"=0.634 and p<0.001.
Conclusion : The diffusion weighted images was considered very useful to speculate the degree of differentiation of HCC. It may influence the theraputic strategy of HCC.

Research Products

• [Journal Article] CT laparoscopy for detecting small superficial metastatic lesions of the liver surface: initial experience. (2008)
  • Author(s): Yoji Maetani, et. al.
  • Journal Title: AJR American Journal of Roentogenlogy 190 Pages: 1314-1317
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma in Patients Undergoing Living-Donor Liver Transplantation. Accuracy of Multi=detector Computed tomogarphy by Viewing Images on Digital Monitors (2008)
  • Author(s): Yoji Maetani, et. al.
  • Journal Title: INTERVIROLOGY 発表確定
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CT laparoscopy for detecting small liver metastasis of the liver surface (2008)
  • Author(s): Yoji Maetani, et. al.
  • Journal Title: AJR American Journal of Roentogenlogy (In press)
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma in Patients Underegoing Living-Donor Liver Transplantation. Accuracy of Multi=detector Computed tomogarphy by Viewing Images on Digital Monitars (2008)
  • Author(s): Yoji Maetani, et. al.
  • Journal Title: INTERVIROLOGY (In press)
• [Journal Article] MRI of the female peivis at 31 compared to 1.51 : evaluation on high-resolution T2-weighted and HASTE images. (2007)
  • Author(s): Kataoka M, Kido A, Maetani Y, et al.
  • Journal Title: J Magn Reson Imaging 25(3) Pages: 527-534
• [Journal Article] Crane-neck deformity after right lobe living donor liver transplantation. (2006)
  • Author(s): Yoshimoto T, Yazumi S, Maetani Y, et al.
  • Journal Title: Gastrointest Endosc. 64(2) Pages: 271-271
• [Journal Article] Outcome of percutaneous transhepatic venoplasty for hepatic venous outflow obstruction after living donor liver transplantation. (2006)
  • Author(s): Kubo T, Shibata T, Itoh K, Maetani Y, et al.
  • Journal Title: Radiology 239(1) Pages: 285-290
• [Journal Article] Living donor liver transplantation as a second-line therapeutic strategy for patients with hepatocellular carcinoma. (2006)
  • Author(s): Takada Y, Ueda M, Maetani Y, et al.
  • Journal Title: Liver Transpl. 12(6) Pages: 912-919
• [Journal Article] Radiofrequency ablation for small hepatocellular carcinoma : prospective comparison of internally cooled electrode and expandable electrode. (2006)
  • Author(s): Shibata T, Shibata T, Maetani Y, et al.
  • Journal Title: Radiology 238(1) Pages: 346-353
• [Journal Article] Transcatheter arterial embolization for tumor seeding in the chest wall after radiofrequency ablation for hepatocellular carcinoma. (2006)
  • Author(s): Shibata T, Shibata T, Maetani Y, et al.
  • Journal Title: Cardiovasc Intervent Radiol. 29(3) Pages: 479-481
• [Journal Article] Efficacy of the Combination of Paging Method and Multiplannar CT images in the Diagnosis of Small Hepatocellular Carcinoma in Liver Transplant Candidates
  • Author(s): Yoji Maetani, et. al.
  • Journal Title: Radiology 発表確定
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CT laparoscopy for detecting small superficial metastatic lesions of the liver surface : initial experience
  • Author(s): Maetani, Y., Isoda, H., Nomura, K., Hirokawa, Y., Arizona, S., Shimada, K., Togashi, K
  • Journal Title: AJR 2008 May 190(5) Pages: 1314-1317
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficacy of the Combination of Paging Method and Multiplannar CT images in the Diagnosis of Small Hepatocellular Carcinoma in Liver Transplant Candidates
  • Author(s): Maetani, Y., Ueda, M., Haga, H., Takada, Y., Isoda, H., Hirokawa, Y., Arizono, S., Shimada, K
  • Journal Title: Radiology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hepatocellular carcinoma in Patients Undergoing Living-Donor Liver Transplantation. Accuracy of Multi=detector Computed tomogarphy by Viewing Images on Digital Monitors
  • Author(s): Maetani, Y., Ueda, M., Haga, H., Takada, Y., Isoda, H., Hirokawa, Y., Arizono, S., Shimada, K
  • Journal Title: INTERVIROLOGY (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Non-contrast-enhanced hepatic MR angiography with true steady-state free-precession and time spatial labeling inversion pulse : Optimization of the technique and preliminary results
  • Author(s): Shimada, K., Isoda, H., Okada, T., Maetani, Y., Hirokawa, Y., Arizona, S., Kamae, T., Togashi, K
  • Journal Title: Eur J Radiology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High Spatial 3D MR cholanghiography Using High Sampling Efficacy Technique (SPACE) at 3T. : Comparison with Conventional Contrast Efficacy Technique Flip Angle Sequence in Healthy Volunteers
  • Author(s): Hirokawa, Y., Isoda, H., Maetani, Y., Arizona, S., Shimada, K., Togashi, K
  • Journal Title: JMRI (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] MR Image Artifact Reduction and Quality Improvement in the the Upper Abdomen with the PROPELLA (BLADE) and Navigator Triggered Prospective Acquisition Correction (pACE) technique
  • Journal Title: AJR (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evalkuation of Motion Correction Effect and Image Quality with the PROPELLAR(BLADE) and Parallel. Imaging Acquisition Tequnique
  • Author(s): Hirokawa, Y., Isoda, H., Maetani, Y., Arizono, S., Shimada, K., Togashi, K
  • Journal Title: JMRI (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficacy of the Combination of Paging Method and Multiplannar CT images in the Diagnosis of Small Hepatocellular Carcinoma in Liver Transplant Candidates
  • Author(s): Yoji Maetani, et. al.
  • Journal Title: Radiology (In press)
  • Peer Reviewed
• [Presentation] Hepatocellular carcinoma in patients undergoing living-donor liver Transplantation: Accuracy of multidetector computed tomography by Viewing images on digital monitars. (2008)
  • Author(s): Yoji Maetani, et. al.
  • Organizer: European Congress of Radiology
  • Place of Presentation: Wien, Austria
  • Year and Date: 2008-03-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CT Laparoscopy for Detecting Small Superficial Metastasis of the Liver Surface. (2008)
  • Author(s): Yoji Maetani, et. al.
  • Organizer: European Congress of Radiology
  • Place of Presentation: Wien, Austria
  • Year and Date: 2008-03-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CT Lapaloscopy for Detecting Small Superficial Metastasis of the Liver Surface (2008)
  • Author(s): Maetani, Y., Isoda, H., Hirokawa, Y., Arizona, S., Shimada, K., Togashi, K
  • Organizer: European Congress of Radiology
  • Place of Presentation: Wien, Austria
  • Year and Date: 2008-03-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CT Laparoscopy for Detecting Small Superficial Metastasis of the Liver Surface (2008)
  • Author(s): Yoji Maetani, et. al.
  • Organizer: European Congress of Radiology
  • Place of Presentation: Wien
  • Year and Date: 2008-03-07
• [Presentation] Hepatocellular carcinoma in patients undergoing living-donor liver Transplantation : Accuracy of multidetector computed tomography by Viewing images on digital monitars (2007)
  • Author(s): Maetani, Y., Isoda, H., Hirokawa, Y., Arizono, S., Shimada, K., Togashi, K
  • Organizer: European congress of Radiology
  • Place of Presentation: Wien, Austria
  • Year and Date: 2007-03-10
  • Description: 「研究成果報告書概要(欧文)」より