| Project/Area Number |
18591344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
MURASE Kenya Osaka University, Graduate School of Medicine, Professor (50157773)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Youichi Osaka Univetsty, Graduate School of Medicine, Assistant Professor (70379270)
FUJITA Norihiko Osaka Univetsty, Hospital, Associate Professor (00283763)
TANAKA Hisashi Osaka Univetsty, Graduate School of Medicine, Associate Professor (40294087)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | magnetic resonance imaging / comnutational fluid dynamics / hemodynamics / blood flow / wall shear stress / intravascular nressure / intracardiac pressure |
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| Research Abstract |
Recently, there has been a great progress in the diagnostic method using magnetic resonance imaging (MRI) in terms of the improvement and development of new software. The purpose of this research project is to develop a method to analyze hemodynamics with high accuracy using MRI combined with computation fluid dynamics (CFD).
In 2006, we developed a software to analyze hemodynamics using MRI combined with CFD. To validate the accuracy of our method, we also constructed a pulsatile flow phantom and generated the three-dimensional images of wall shear stress from the data acquired using MRI and this phantom.
In 2007, we continued to develop a software to analyze hemodynamics using MRI combined with CFD. Furthermore, we developed a method to measure the intravascular and intracardiac pressure differences using our software. The intravascular pressure differences obtained by our method agreed well with those estimated theoretically. In conclusion, our software developed in this research project appears to be useful for analyzing hemodynamics with high accuracy and to estimate the biomechanical parameters such as wall shear stress and intravascular and intracardiac pressure differences. However, further studies are necessary to establish the usefulness of our method, and these studies are currently in progress.
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