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Prediction of prognosis of patients with breast cancer using contrast-enhanced dynamic, diffusion-weighted MR image, and MR spectroscopy

Research Project

Project/Area Number 18591352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

YABUUCHI Hidetake  Kyushu University, 大学病院, 講師 (70380623)

Co-Investigator(Kenkyū-buntansha) 神谷 武志  九州大学, 大学病院, 医員 (20419534)
松尾 芳男 (松尾 芳雄)  九州大学, 大学病院, 助手 (50419595)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords乳癌 / MRI / 予後予測 / 拡散強調 / 造影ダイナミックMRI / 乳腺 / 予後因子 / 造影ダイナミックスタデイ
Research Abstract

乳癌の予後に直接関係する因子として腋窩リンパ節転移の検出能・診断能を、拡散強調像およびリンパ節のADC値を用いて解析した。その結果、腋窩リンパ節転移陽性例では転移陰性例よりも有意にADC値が高く、また、拡散強調MRIでリンパ節の指摘が困難な症例ではほぼ腋窩リンパ節転移陰性であった。またサイズ(6mm以上、5mm未満)との組み合わせにより更に診断能が向上した。
更に乳癌原発巣のADC値を解析し、組織学的悪性度やホルモンレセプター(ER, PgR)の状態、HER2の状態との相関を検討した。その結果、腋窩リンパ節陽性例は陰性例に比較してADC値が有意に高かった。またER陽性例は陰性例に比較して、ADC値が優位に低かった。一方、核異型度やPgR、HER2の状態(陽性か陰性)は、ADC値との相関は見られなかった。
これらの結果より、拡散強調MRIによる原発巣および腋窩リンパ節のADC値の解析は、腋窩リンパ節転移やERの状態の予測に有用で、治療方針の決定にも影響を与える情報が得られる可能性が示唆された。
また、造影ダイナミックMRIと拡散強調MRIの組み合わせによる良悪性鑑別診断能についても単変量・多変量解析を行い、ADC値は辺縁性状(スピキュラや不整)、内部造影効果(均一、不均一、リムを伴う)と共に独立した鑑別因子であった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 2007 2006

All Journal Article (10 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Enhanced mass on contrast-enhanced breast MR imaging : Lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR images2008

    • Author(s)
      Yabuuchi H, Matsuo Y, Okafuji T, Kamitani T, Soeda H, Setoguchi T, Sakai S, Hatakenaka M, Honda H
    • Journal Title

      J Magn Reson Imaging 28(5)

      Pages: 1157-65

    • Related Report
      2008 Final Research Report
  • [Journal Article] Enhanccd mass on contrast-cnhanced breast MR imaging : Lesion characterization using combination of dynamic contrast-cnhanced and diffusion-weighted MR images2008

    • Author(s)
      藪内 英剛
    • Journal Title

      Journal of Magnetic Resonance Imaging 28

      Pages: 1157-1165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 造影ダイナミックMRIと拡散強調MRIの組み合わせによる乳腺腫瘤の良悪性診断能2007

    • Author(s)
      藪内英剛、松尾芳雄、神谷武志
    • Journal Title

      ROC解析による検討映像情報Medical 39

      Pages: 930-935

    • Related Report
      2008 Final Research Report
  • [Journal Article] 造影ダイナミックMRIと拡散強調MRIの組み合わせによる乳腺腫瘤の良悪性診断能:ROC解析による検討2007

    • Author(s)
      藪内 英剛
    • Journal Title

      映像情報Medical 39

      Pages: 930-935

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Incidentally detected lesions on contrast-enhanced MR imaging in candidates for breast-conserving therapy : correlation between MR findings and histological diagnosis2006

    • Author(s)
      Yabuuchi H, Kuroiwa T, Kusumoto C, Fukuya T, Ohno S, Hachitanda Y
    • Journal Title

      J Magn Reson Imaging 23(4)

      Pages: 486-492

    • Related Report
      2008 Final Research Report
  • [Journal Article] MR imaging features of pure mucinous carcinoma of the breast2006

    • Author(s)
      Okafuji T, Yabuuchi H, Sakai S, Soeda H, Matsuo Y, Inoue T, Hatakenaka M, Takahashi N, Kuroki S, Tokunaga E, Honda H
    • Journal Title

      Eur J Radiol 60(3)

      Pages: 405-413

    • Related Report
      2008 Final Research Report
  • [Journal Article] Incidentally detected lesions on contrast-enhanced MR imaging in candidates for breast-conserving therapy : correlation between MR findings and histological diagnosis.2006

    • Author(s)
      Yabuuchi H, Kuroiwa T, Kusumoto C, Fukuya T, Ohno S, Hachitanda Y :
    • Journal Title

      J Magn Reson Imaging. 23(4)

      Pages: 486-92

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MR imaging features of pure mucinous carcinoma of the breast.2006

    • Author(s)
      Okafuji T, Yabuuchi H, Sakai S, Soeda H, Matuso Y, Inoue T, Hatakenaka M, Takahashi N, Kuroki S, Tokunaga E, Honda H :
    • Journal Title

      Eur J Radiol. 60(3)

      Pages: 405-13

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phyllodes tumor of the breast : correlation between MR findings and histologic grade.2006

    • Author(s)
      Yabuuchi H, Soeda H, Matsuo Y, Okafuji T, Eguchi T, Sakai S, Kuroki S, Tokunaga E, Ohno S, Nishiyama K, Hatakenaka M, Honda H :
    • Journal Title

      Radiology. 241(3)

      Pages: 702-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Detection of masses and microcalcifications of breast cancer on digital mammograms : comparison among hard-copy film, 3-megapixel liquid crystal display (LCD) monitors and 5-megapixel LCD monitors : an observer performance study.2006

    • Author(s)
      Kamitani T, Yabuuchi H, Soeda H, Matsuo Y, Okafuji T, Sakai S, Furuya A, Hatakenaka M, Ishii N, Honda H :
    • Journal Title

      Eur Radiol. Epub ahead of print (web)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 乳癌の原発巣のADC値と腋窩リンパ節転移の有無との相関の検討2009

    • Author(s)
      神谷武志、藪内英剛、角南俊也、瀬戸口太郎、坂井修二、畠中正光、本田浩
    • Organizer
      日本医学放射線学会総会
    • Year and Date
      2009-04-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 乳癌腋窩リンパ節転移の評価における拡散強調MRIの有用性の検討2008

    • Author(s)
      神谷武志、藪内英剛、松尾芳雄、瀬戸口太郎、坂井修二、畠中正光、本田浩
    • Organizer
      日本医学放射線学会総会
    • Year and Date
      2008-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 乳癌腋窩リンパ節転移の評価における拡散強調MRIの有用性の検討2008

    • Author(s)
      神谷 武志
    • Organizer
      日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-04
    • Related Report
      2007 Annual Research Report
  • [Presentation]2008

    • Author(s)
      神谷 武志
    • Organizer
      Annual Meeting of Eadiological Society of North America
    • Place of Presentation
      Chicago, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Can diffusion-weighted imaging in addition to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization of breast lesions? -ROC analysis2006

    • Author(s)
      Hidetake Yabuuchi, Hiroyasu Soeda, Yoshio Matsuo, Takashi Okafuji, Takashi Eguchi, Shuji Sakai, Syoji Kuroki, Eriko Tokunaga, Shinji Ohno, Kenichi Nishiyama, Masamitsu Hatakenaka, Hiroshi Honda
    • Organizer
      The 72th Scientific Assembly and Annual Meeting Radiological Society of North America
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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