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Establishment of statistical image analysis for diagnosis of very early Alzheimer's disease

Research Project

Project/Area Number 18591364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionSaitama Medical University

Principal Investigator

MATSUDA Hiroshi  Saitama Medical University, 医学部, 教授 (90173848)

Co-Investigator(Kenkyū-buntansha) KUJI Ichiei  埼玉医科大学, 医学部, 准教授 (90283142)
IMABAYASHI Etsuko  埼玉医科大学, 医学部, 講師 (30406491)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,130,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords核磁気共鳴画像 / 核医学 / 放射性医薬品・造影剤 / 医用画像工学 / 神経科学 / 認知症 / 脳神経疾患 / 放射線 / 解剖学 / 痴呆
Research Abstract

アルツハイマー型認知症の前駆段階である認知症状の未だみられない健忘型の軽度認知障害患者における早期画像診断法をMRI と脳血流SPECT を用いて確立した。健常高齢者においてMRI と脳血流SPECT を撮像し、解剖学的標準化と平滑化により健常者画像データベースを構築した。このデータベースを用いて、個々の患者においてアルツハイマー型認知症に特異的な脳萎縮部位と脳血流低下部位を検出したところ、両者の組み合わせにより90%以上の診断率が得られた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (50 results)

All 2008 2007 2006

All Journal Article (24 results) (of which Peer Reviewed: 18 results) Presentation (10 results) Book (11 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Comparison of SPM and NEUROSTAT in voxelwise statistical analysis of brain SPECT and MRI at the early stage of Alzheimer's disease.2008

    • Author(s)
      Nishimiya M, Matsuda H, Imabayashi E, Kuji I, Sato N.
    • Journal Title

      Ann Nucl Med 22

      Pages: 921-927

    • NAID

      10025135020

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early diagnostic value of brain perfusion SPECT using an easy Z-score imaging system in patients with neurodegenerative disease.2008

    • Author(s)
      Waragai M, Yamada T, Matsuda H.
    • Journal Title

      Dement Geriatr Cogn Disord. 26

      Pages: 547-555

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nilvadipine on regional cerebral blood flow in a patient with early Alzheimer's disease.2008

    • Author(s)
      Matsuda H, Araki N, Kuji I, Ohkubo T, Imabayashi E, Shimazu K.
    • Journal Title

      Clin Nucl Med 33

      Pages: 34-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nilvadipine on regional cerebral blood flow in a patient with early Alzheimer's disease2008

    • Author(s)
      Matsuda H
    • Journal Title

      Clinical Nuclear Medicine 33

      Pages: 34-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early diagnostic value of brain perfusion SPECT using an easy Z-score imaging system in patients with neurodegenerative disease.2008

    • Author(s)
      Waragai M
    • Journal Title

      Dementia and geriatric cognitive disorders 26

      Pages: 547-555

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of SPM and NEUROSTAT in voxelwise statistical analysis of brain SPECT and MRI at the early stage of Alzheimer's disease.2008

    • Author(s)
      Nishimiya M
    • Journal Title

      Annals of Nuclear Medicine 22

      Pages: 921-927

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of neuroimaging in mild cognitive impairment.2007

    • Author(s)
      Matsuda H.
    • Journal Title

      Neuropathology 27

      Pages: 570-577

    • NAID

      10021237031

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of neuroimaging in Alzheimer's disease with emphasis on brain perfusion SPECT.2007

    • Author(s)
      Matsuda H.
    • Journal Title

      J Nucl Med 48

      Pages: 1289-1300

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of brain perfusion SPECT using an easy Z-score imaging system (eZIS) as an adjunct to early-diagnosis of neurodegenerative diseases.2007

    • Author(s)
      Waragai M, Yamada T, Matsuda H.
    • Journal Title

      J Neurol Sci. 260

      Pages: 57-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial volume effect corrected FDG PET and gray matter volume loss in patients with mild Alzheimer's disease.2007

    • Author(s)
      Samuraki M, Matsunari I, Chen WP, Yajima K, Yanase D, Fujikawa A, Takeda N, Nishimura S, Matsuda H, Yamada M.
    • Journal Title

      Eur J Nucl Med Mol Imaging 34

      Pages: 1658-1669

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Automated discrimination between very early Alzheimer disease and controls using an easy Z-score imaging system for multicenter brain perfusion single-photon emission tomography.2007

    • Author(s)
      Matsuda H, Mizumura S, Nagao T, Ota T, Iizuka T, Nemoto K, Takemura N, Arai H, Homma A.
    • Journal Title

      Am J Neuroradiol AJNR 28

      Pages: 731-736

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of FDG PET and Optimized Voxel-Based Morphometry for the Detection of Alzheimer's Disease: Aging Effect on Diagnostic Performance .2007

    • Author(s)
      Matsunari I, Samuraki M, Chen WP, Yanase D, Takeda N, Ono K, Yoshita M, Matsuda H, Yamada M, Kinuya S
    • Journal Title

      J Nucl Med 48

      Pages: 1961-1971

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased cerebral blood flow and prognosis of Alzheimer's disease: a multicenter HMPAO-SPECT study.2007

    • Author(s)
      Nishimura T, Hashikawa K, Fukuyama H, Kubota T, Kitamura S, Matsuda H, Hanyu H, Nabatame H, Oku N, Tanabe H, Kuwabara Y, Jinnouchi S, Kubo A.
    • Journal Title

      Ann Nucl Med 21

      Pages: 15-23

    • NAID

      10018516282

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An easy Z-score imaging system for discrimination between very early Alzheimer's disease and controls using brain perfusion SPECT in a multicenter study.2007

    • Author(s)
      Matsuda H, Mizumura S, Nagao T, Ota T, Iizuka T, Nemoto K, Kimura M, Tateno A, Ishiwata A, Kuji I, Arai H, Homma A.
    • Journal Title

      Nucl Med Commun 28

      Pages: 199-205

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of neuroimaging in Alzheimer's disease with emphasis on brain perfusion SPECT2007

    • Author(s)
      Matsuda H
    • Journal Title

      J Nucl Med 48

      Pages: 1289-1300

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of neuroimaging in mild cognitive impairment2007

    • Author(s)
      Matsuda H
    • Journal Title

      Neuropathology 27

      Pages: 570-577

    • NAID

      10021237031

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of FDG PET and Optimized Voxel-Based Morphometry for the Detection of Alzheimer's Disease:Aging Effect on Diagnostic Performance2007

    • Author(s)
      Matsunari I
    • Journal Title

      J Nucl Med 48

      Pages: 1961-1970

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An easy Z-score imaging system for discrimination between very early Alzheimer's disease and controls using brain perfusion SPECT is a multicenter study.2007

    • Author(s)
      Matsuda H
    • Journal Title

      Nucl Med Commun 28・3

      Pages: 199-205

    • Related Report
      2006 Annual Research Report
  • [Journal Article] changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression : a PET study.2007

    • Author(s)
      Takano H
    • Journal Title

      Br J Psychiatry 190・1

      Pages: 63-68

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Decreased cerebral blood flow and prognosis of Alzheimer's disease : a multicenter HMPAO-SPECT study.2007

    • Author(s)
      Nishimura T
    • Journal Title

      Ann Nucl Med 21・1

      Pages: 15-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between antisocial behavior and regional cerebral blood flow in frontotemporal dementia.2006

    • Author(s)
      Nakano S, Asada T, Yamashita F, Kitamura N, Matsuda H, Hirai S, Yamada T.
    • Journal Title

      Neuroimage 32

      Pages: 301-306

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional neuroimaging in Alzheimer's disease.2006

    • Author(s)
      Matsuda H
    • Journal Title

      Radiation medicine 24・4

      Pages: 302-308

    • NAID

      10018150750

    • Related Report
      2006 Annual Research Report
  • [Journal Article] comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease.2006

    • Author(s)
      Kawachi T
    • Journal Title

      Eur J Nucl Med Mol Imaging. 33・7

      Pages: 801-809

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship between antisocial behavior and regional cerebral blood flow in frontotemporal dementia.2006

    • Author(s)
      Nakano S
    • Journal Title

      Neuroimage 32・1

      Pages: 301-306

    • Related Report
      2006 Annual Research Report
  • [Presentation] High-dimensional warping elevates statistical significance in voxel-based analysis of brain perfusion SPECT in Alzheimer's disease.2008

    • Author(s)
      Matsuda H, Imabayashi E, Kuji I, Seto A, Itoh K, Yamada M.
    • Organizer
      the 21st annual congress of the EANM in 2008
    • Place of Presentation
      Munich
    • Year and Date
      2008-10-14
    • Related Report
      2008 Final Research Report
  • [Presentation] FDG PET in Relation to Atrophic Pattern Using Voxel-Based Morphometry in Patients with Alzheimer's Disease: The Ishikawa Brain Imaging Study.2008

    • Author(s)
      Shima K, Matsunari I, Samuraki M, Chen W, Yanase D, Takeda N, Yoshita M, Nishimura S, Matsuda H, Yamada M.
    • Organizer
      the 21st annual congress of the EANM in 2008
    • Place of Presentation
      Munich
    • Year and Date
      2008-10-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Prevalence of Reduced Glucose Metabolism or Gray-Matter Concentration in Healthy Apo E ε 4 Carriers: The Ishikawa Brain Imaging Study2008

    • Author(s)
      Samuraki M, Matsunari I, Chen W, Yajima K, Yanase De, Fujikawa A, Takeda N, Nishimura S, Matsuda H, Yamada M.
    • Organizer
      the 21st annual congress of the EANM in 2008
    • Place of Presentation
      Munich
    • Year and Date
      2008-10-14
    • Related Report
      2008 Final Research Report
  • [Presentation] High-dimensional warping elevates statistical significance in voxel-based analysis of brain perfusion SPECT in Alzheimer's disease.2008

    • Author(s)
      Matsuda H
    • Organizer
      the 21st annual congress of the European Association of Nuclear Medicine
    • Place of Presentation
      Munich
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウムII「アルツハイマー病早期診断:画像診断を中心に」2008

    • Author(s)
      松田博史
    • Organizer
      MRI , 第27 回日本認知症学会
    • Place of Presentation
      前橋
    • Year and Date
      2008-10-10
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of neuroimaging in Alzheimer's disease. Symposium, New Biomarkers for Early detection and differentiation of Dementia Alzheimer's Type.2008

    • Author(s)
      Matsuda H.
    • Organizer
      2^<nd> WFSBP (World Federation of Societies of Biological Psychiatry) Asia-Pacific Congress
    • Place of Presentation
      Toyama-city
    • Year and Date
      2008-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of brain perfusion SPECT in dementia.2007

    • Author(s)
      Matsuda H.
    • Organizer
      Continuing Education Seminar, The 54^<th> SNM annual meeting
    • Place of Presentation
      Washinton DC
    • Year and Date
      2007-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of brain perfusion SPECT in dementia2007

    • Author(s)
      Hiroshi Matsuda
    • Organizer
      The 54th SNM annual meeting
    • Place of Presentation
      Washinton DC
    • Year and Date
      2007-06-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] FDG PET in patients with mild Alzheimer's disease before and after correction for cortical atrophy.2006

    • Author(s)
      Samuraki M, Matsunari I, Chen W, Yajima K, Yanase D, Fujikawa A, Takeda N, Nishimura S, Matsuda H, Yamada M.
    • Organizer
      53^<nd> Annual meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Diego
    • Year and Date
      2006-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Head-to-head comparison of FDG PET and voxel-based morphometry for the detection of Alzheimer's disease.2006

    • Author(s)
      Matsunari I, Samuraki M, Chen W, Yanase D, Takeda N, Matsuda H, Yamada M, Tonami N.
    • Organizer
      53^<nd> Annual meeting of Society of Nuclear Medicine
    • Place of Presentation
      San Diego
    • Year and Date
      2006-06-05
    • Related Report
      2008 Final Research Report
  • [Book] 統計的脳機能解析、核医学検査技術学(改訂2版)、日本放射線技術学会2008

    • Author(s)
      松田博史(大西英雄、松本政点、増田一孝(編))
    • Publisher
      オーム社、東京
    • Related Report
      2008 Final Research Report
  • [Book] PET,SPECT, 精神疾患と脳画像2008

    • Author(s)
      松田博史(福田正人編)
    • Publisher
      中山書店、東京
    • Related Report
      2008 Final Research Report
  • [Book] PET,精神疾患の脳画像解析・診断学2008

    • Author(s)
      今林悦子、松田博史(平安良雄、笠井清登編)
    • Publisher
      南山堂、東京
    • Related Report
      2008 Final Research Report
  • [Book] 画像診断。認知症テキストブック、日本認知症学会2008

    • Author(s)
      松田博史
    • Publisher
      中外医学社
    • Related Report
      2008 Final Research Report
  • [Book] 認知症テキストブック2008

    • Author(s)
      松田博史
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report
  • [Book] 画像診断:形態・機能変化軽度認知障害(MCI)。認知症に先手をうつ2007

    • Author(s)
      松田博史(朝田 隆編)
    • Publisher
      中外医学社、東京
    • Related Report
      2008 Final Research Report
  • [Book] 軽度認知障害(MCI)認知症に先手をうつ2007

    • Author(s)
      松田 博史(共蓍)
    • Total Pages
      293
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 認知症性疾患におけるSPECT の基礎知識。精神・神経疾患画像アトラス2006

    • Author(s)
      松田博史(葛原茂樹編)
    • Publisher
      メディカルレビュー社、東京
    • Related Report
      2008 Final Research Report
  • [Book] SPECT。老年期認知症ナビゲーター2006

    • Author(s)
      松田博史(平井俊索(監修))(荒井啓行、浦上克哉、武田雅俊、本間 昭(編))
    • Publisher
      メディカルレビュー社、東京
    • Related Report
      2008 Final Research Report
  • [Book] 画像(SPECT,MRI)。アルツハイマー病診断2006

    • Author(s)
      松田博史(村山繁雄編)
    • Publisher
      真興交易(株)医書出版部、東京
    • Related Report
      2008 Final Research Report
  • [Book] アルツハイマー病診断、画像(SPECT,MRI)2006

    • Author(s)
      松田博史(共著)
    • Total Pages
      234
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 画像診断支援システム2008

    • Inventor(s)
      松田博史、竹村直治、相馬 努
    • Industrial Property Rights Holder
      富士フィルムRIファーマ株式会社
    • Acquisition Date
      2008-08-01
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 画像診断支援システム2008

    • Inventor(s)
      松田博史
    • Industrial Property Rights Holder
      富士フィルムR Iファーマ
    • Acquisition Date
      2008-08-01
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳疾患の診断支援方法および装置2007

    • Inventor(s)
      松田博史、小野徹太郎、松葉靖寿
    • Industrial Property Rights Holder
      国立精神・神経センター総長、大日本印刷株式会社
    • Acquisition Date
      2007-10-19
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 脳疾患の診断支援方法および装置2007

    • Inventor(s)
      松田博史、小野徹太郎、松葉靖寿
    • Industrial Property Rights Holder
      国立精神・神経センター総長、大日本印刷株式会社
    • Acquisition Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 異条件下における脳機能画像の画像間差補正法2007

    • Inventor(s)
      松田博史、水村 直、相馬 努
    • Industrial Property Rights Holder
      富士フィルムRIファーマ株式会社、国立精神・神経センター総長
    • Acquisition Date
      2007-10-12
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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