• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the algorithm for quantitative neuroreceptor imaging using PET without serial arterial blood sampling and reference region

Research Project

Project/Area Number 18591373
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences (2007)
Tokyo Metropolitan Institute of Gerontology (2006)

Principal Investigator

KIMURA Yuichi  National Institute of Radiological Sciences, Molecular Imaging Center, Team Leader (60205002)

Co-Investigator(Kenkyū-buntansha) ISHIWATA Kiichi  Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Head (50143037)
ODA Keiichi  Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Researcher (70224235)
ISHII Kenji  Tokyo Metropolitan Institute of Gerontology, Positron Medical Center, Head of Clinic (10231135)
WATABE Hiroshi  National Cardiovascular Center, Department of Investigative Radiology, Laboratory Chief (40280820)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,950,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsPET / molecular imaging / neuroreceptor / medical image / nuclear medicine / 医用画像処理
Research Abstract

This study aims at developing algorithms for fully quantitative neuroreceptor imaging using PET without serial arterial blood sampling and reference regions. For omission of serial arterial blood sampling, variational Bayesian approach and an intersectional searching approach were investigated based on Logan graphical analysis (LGA). As a result, dynamic studies using FDG, MPDX and TMSX were accomplished without serial arterial blood sampling. The variational Bayesian approach introduces nonnegative constraints to an algorithm based on independent component analysis which has been developed by my group. The approaches improved an estimation performance of a time history of radioactivity in arterial blood (pTAC), and it made an estimated blood volume image, which was another outcome of the algorithm, physiologically reliable. Other algorithm based on LGA is to estimate pTAC using the operational equation of LGA, for which the terms including pTAC were canceled out using pTAC is common among regions. This algorithm was sensitive for noise in PET data due to its mathematical framework. In order to realize reliable pTAC estimation, some data preprocessing procedures were developed using clustering based on a kinetics of administered radiopharmaceutical For the omission of reference region, a feasibility of voxel-based compartment model analysis was investigated. However, it was not practical due to bad noise statistics in voxel-based PET data. Then, total distribution volumes (VT) was estimated for each voxels to decrease the number of estimated rate constants using LGA. The VT estimates by LGA is underestimated under the existence of large noise in PET data. MAP based estimation approach was incorporated with LGA, and fast and statistically reliable voxel-based VT estimation was archived.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (17 results)

All 2008 2007 2006

All Journal Article (14 results) (of which Peer Reviewed: 6 results) Presentation (3 results)

  • [Journal Article] Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging2008

    • Author(s)
      M Naganawa, Y Kimura, et. al.
    • Journal Title

      NeuroImage 40

      Pages: 26-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomograpny for neuroreceptor imaging2008

    • Author(s)
      M Naganawa, Y kimura, et. al.
    • Journal Title

      NeuroImage 40

      Pages: 26-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography2007

    • Author(s)
      M Naganawa, Y Kimura, et. al.
    • Journal Title

      Euro J Nucl Med Molecul Imaging 34

      Pages: 679-687

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mapping of human cerebral sigmal receptors using positron emission to mography and [11C]SA45032007

    • Author(s)
      M Sakata, Y Kimura, et. al.
    • Journal Title

      NeuroImage 35

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Time and Spatial blood information estimation using Bayesian ICA in dynamic cerebral positron emission tomography2007

    • Author(s)
      M Naganawa, Y Kimura, et. al.
    • Journal Title

      Dig Sig Proc 17

      Pages: 979-993

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Distribution volume as an alternative to the binding potential for sigmal receptor imaging2007

    • Author(s)
      Y Kimura, M Naganawa, et. al.
    • Journal Title

      Ann Nucl Med 21

      Pages: 533-535

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Quantification of adenosine A2A receptors in the human brain using [11C] TMSX and positron emission tomography2007

    • Author(s)
      M Naganawa, Y Kimura, et. al.
    • Journal Title

      Eur J Nucl Med Molecul Imaging 34

      Pages: 679-687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mapping of human cerebral sigmal receptors using positron emission tomography and [11C] SA45032007

    • Author(s)
      M Sakata, Y Kimura, et. al.
    • Journal Title

      NeuroImage 35

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Time and Spatial bllod information estimationusing Bayesian ICA in dynamic cerebral positron emission tomography2007

    • Author(s)
      M Naganawa, Y, Kimura, et. al.
    • Journal Title

      Dig Sig Proc 17

      Pages: 979-993

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Quantification of adenosine A_2A receptors in the human brain using [^11C] TMSX and positron emission tomography2007

    • Author(s)
      M.Naganawa, Y.Kimura, et al.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mapping of human cerebral sigma_1 receptors using positron emission tomography and [^11C]SA45032007

    • Author(s)
      M.Sakata, Y.Kimura, et al.
    • Journal Title

      NeuroImage 35・1

      Pages: 1-8

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Temporal and spatial blood information estimation using Bayesian ICA in dynamic cerebral positron emission tomography2007

    • Author(s)
      M.Naganawa, Y.Kimura, et al.
    • Journal Title

      Digital Signal Processing (In Press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MAP-based Kinetic Analysis for Voxel-by-Voxel Compartment Model Estimation : Detailed Imaging of the Cerebral Glucose Metabolism using FDG2006

    • Author(s)
      Y Kimura, M Naganawa, et. al.
    • Journal Title

      NeuroImage 29

      Pages: 1203-1210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] MAP-based kinetic analysis for voxel-by-voxel compartment model estimation : detailed imaging of the cerebral glucose metabolism using FDG2006

    • Author(s)
      Y.Kimura, M.Naganawa, et al.
    • Journal Title

      NeuroImage 29

      Pages: 1203-1211

    • Related Report
      2006 Annual Research Report
  • [Presentation] Voxel-by-voxel compartment analysis using clustering kinetic approach for PET applying to P-glycoprotein functional imaging2007

    • Author(s)
      Y Kimura, M Naganawa, et. al.
    • Organizer
      Proceedings of Joint Molecular Imaging Conference 2007
    • Place of Presentation
      Providence, RI, USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Voxel-by-voxel compartment a nalysis using clustering kinetic approach for PET applying to P-glycoprotein functional imaging2007

    • Author(s)
      Y Kimura, M Naganawa, et. al.
    • Organizer
      Joint Molecular Imaging Conference
    • Place of Presentation
      Providence, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Voxel-by-voxel compartment analysis using clustering kinetic approach for PET applying to P-glycoprotein functional imaging2007

    • Author(s)
      Y Kimura, M Naganawa, et. al.
    • Organizer
      Proceedings of Joint Molecular Imaging Conference 2007
    • Place of Presentation
      Providence,RI,USA
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi