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Boron neutron capture therapy for malignant pleural mesothelioma

Research Project

Project/Area Number 18591379
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

SUZUKI Minoru  Kyoto University, 原子炉実験所・附属粒子線腫瘍学研究センター, 准教授 (00319724)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords悪性胸膜中皮腫 / 硼素中性子捕捉療法
Research Abstract

手術不能である悪性胸膜中皮腫に対する新規治療方法として、硼素中性子捕捉療法の適用が可能であるか否かの基礎的検討を実施した.悪性中皮腫モデルマウスを用いて硼素中性子捕捉療法が重篤な肺障害を与えず、中皮腫の縮小効果と生存期間を延長させることを明らかにした.また、治療計画研究を実施し正常肺への耐容線量以下で、腫瘍に対して治療効果が期待される線量を投与することが可能であることを明らかにした.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (52 results)

All 2009 2008 2007 2006 Other

All Journal Article (19 results) (of which Peer Reviewed: 18 results) Presentation (33 results)

  • [Journal Article] Survival benefit of boron neutron capture therapy for recurrent malignant gliomas2009

    • Author(s)
      Miyatake SI, Kawabata S, Yokoyama K, Kuroiwa T, Michiue H, Sakurai Y, Kumada H, Suzuki M, Maruhashi A, Kirihata M, Ono K
    • Journal Title

      J Neurooncol 91(2)

      Pages: 199-206

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma2009

    • Author(s)
      鈴木実
    • Journal Title

      Radiotherapy and Oncology

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer2008

    • Author(s)
      Fuwa N, Suzuki M, Sakurai Y, Nagata K, Kinashi Y, Masunaga S, Maruhashi A, Imahori Y, Kodaira T, Tachibana H, Nakamura T, Ono K
    • Journal Title

      Br J Radiol 81(969)

      Pages: 749-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel concept of treatmentof diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT)2008

    • Author(s)
      Suzuki M, Endo K, Satoh H, Sakurai Y, Kumada H, Kimura H, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K
    • Journal Title

      Radiother Oncol 88

      Pages: 192-195

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of neutron capture therapy on the cell cycle of human squamous cell carcinoma cells2008

    • Author(s)
      Kamida A, Fujita Y, Kato I, Iwai S, Ono K, Suzuki M, Sakurai Y, Yura Y
    • Journal Title

      Int J Radiat Biol 84(3)

      Pages: 191-199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiobiological significance of the response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with γ-rays and reactor neutron beams2008

    • Author(s)
      Masunaga S, Ando K, Uzawa K, Hirayama R, Furusawa Y, Koide S, Sakurai Y, Nagata K, Suzuki M, Kashino G, Kinashi Y, Tanaka H, Maruhashi, Ono K
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys 70(1)

      Pages: 221-228

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel concept of treatmentof diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT)2008

    • Author(s)
      鈴木実
    • Journal Title

      Radiotherapy and Oncology 88

      Pages: 192-195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early effects of boron neutron capture therapy on rat glioma models2007

    • Author(s)
      Nakagawa N, Akai F, Fukawa N, Fujita Y, Suzuki M, Ono K, Taneda M
    • Journal Title

      Brain Tumor Pathol 24(1)

      Pages: 7-13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Boron neuron capture therapy using epithermal neutrons for recurrent cancer in the oral cavity and cervical lymph node metastasis2007

    • Author(s)
      Ariyoshi Y, Miyatake S, Kimura Y, Shimahara T, Kawabata S, Nagata K, Suzuki M, Maruhashi A, Ono K, Shimahara M
    • Journal Title

      Oncol Rep 18(4)

      Pages: 861-866

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of micronucleus induction in lymphocytes of patients following Boron-Neutron-Capture-Therapy : A comparison with thyroid cancer patients treated with radioiodine2007

    • Author(s)
      Kinashi Y, Masunaga S, Sakurai Y, Suzuki M, Nagata K, Ono K
    • Journal Title

      J Radiat Res 48

      Pages: 197-204

    • NAID

      110006278194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The bystandar effect observed in boron neutron capture therapy : a study of the induction of mutations in the HPRT locus2007

    • Author(s)
      Kinashi Y, Masunaga S, Nagata K, Suzuki M, Takahashi S, Ono K
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys 68(2)

      Pages: 508-514

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma2007

    • Author(s)
      Suzuki M, Sakurai Y, Hagiwara S, Masunaga S, Kinashi Y,Nagata K, Maruhashi A, Kudo M, Ono K
    • Journal Title

      Jpn J Clin Oncol 37(5)

      Pages: 376-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Y, Nagata K, Maruhashi A, Ono K. Preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity2007

    • Author(s)
      Suzuki M, Sakurai Y, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K
    • Journal Title

      Jap J Clin Oncol 37(4)

      Pages: 245-249

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prellminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity2007

    • Author(s)
      Suzuki M, Sakurai Y, Masunaga S, et. al.
    • Journal Title

      Japanese Journal of Clinical Oncology 37

      Pages: 245-249

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 硼素中性子捕捉療法(Boron Neutron Captufe Therapy; BNCT)の現状と将来展望-癌細胞選択照射がもたらすWhole Organ Radiotherapyの可能性-2007

    • Author(s)
      鈴木 実, 菓子野元郎, 木梨友子, 他3名
    • Journal Title

      映像情報 39

      Pages: 1126-1135

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Feasibility of boron neutron capture therapy (BNCT) for malignant pleural mesothelioma from a viewpoint of dose distribution analysis2006

    • Author(s)
      Suzuki M, Sakurai Y, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys 66(5)

      Pages: 1584-1589

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy2006

    • Author(s)
      Masunaga S, Kasaoka S, Maruyama K, Nigg D, Sakurai Y, Nagata K, Suzuki M, Kinashi Y, Maruhashi A, Ono K
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys 66(5)

      Pages: 1515-1522

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of intra-arterial administration of boron compounds on dose-volume histograms (DVHs) in boron neutron capture therapy (BNCT) for recurrent head and neck tumors2006

    • Author(s)
      Suzuki M, Sakurai Y, Nagata K, Kinashi Y, Masunaga S, Ono K, Maruhashi A, Kato I, Fuwa N, Hiratsuka J, Imahori Y
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys 66(5)

      Pages: 1523-1527

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma

    • Author(s)
      Suzuki M, Tanaka H, Sakurai Y, Kashino G, Yong L, Masunaga S, Kinashi Y, Mitsumoto T, Yajima S, Tsutsui H, Sato T, Maruhashi A, Ono K
    • Journal Title

      Radiother Oncol (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] IGRT, IGRT eraにおけるBNCT-加速器中性子源開発後の先に描く将来展望2008

    • Author(s)
      鈴木実
    • Organizer
      第105回関西Cancer therapistの会
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] IGRT, IGRT eraにおけるBNCT-加速器中性子源開発後の先に描く将来展望-2008

    • Author(s)
      鈴木実
    • Organizer
      第105回関西Cancer therapistの会
    • Place of Presentation
      大阪
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Boron neutron capture therapy (BNCT) for diffuse or multiple pleural tumors : Case reports of two cases2008

    • Author(s)
      鈴木実
    • Organizer
      13th International Conference on Neutron Capture Therapy
    • Place of Presentation
      フイレンツェ
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] IGRT時代における硼素中性子捕捉療法(BNCT)の役割 (シンポジウム 癌の粒子線治療・各療法の特徴とその将来を展望する)2008

    • Author(s)
      鈴木実
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] IGRT時代における硼素中性子捕捉療法(BNCT)の役割(シンポジウム癌の粒子線治療・各療法の特徴とその将来を展望する)2008

    • Author(s)
      鈴木実
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対する棚素中性子捕捉療法(BNCT) : 加速器BNCTと原子炉BNCTの比較2008

    • Author(s)
      鈴木実
    • Organizer
      日本放射線腫瘍学会第21回学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 教育講演「NCTレビュー」8. 肺腫瘍・肝臓癌2008

    • Author(s)
      鈴木実
    • Organizer
      第5回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      倉敷
    • Year and Date
      2008-07-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 教育講演「CTレビュー」8. 肺腫瘍・肝臓癌2008

    • Author(s)
      鈴木実
    • Organizer
      第5回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      倉敷
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加速器中性子源が硼素中性子捕捉療法に与えるimpact - 悪性胸膜中皮腫症例を中心に2008

    • Author(s)
      鈴木実
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 加速器中性子源が硼素中性子捕捉療法に与えるimpact-悪性胸膜中皮腫症例を中心に-2008

    • Author(s)
      鈴木実
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] IMRT,IGRT era におけるBNCT2008

    • Author(s)
      鈴木 実、菓子野元郎、木梨友子、増永慎一郎、小野公二
    • Organizer
      第10回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2008-02-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Boron neutron capture therapy (BNCT) for diffuse or multiple pleural tumors2008

    • Author(s)
      鈴木実
    • Organizer
      Case reports of two cases. 13th International Conference on Neutron Capture Therapy
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法(BNCT) : 加速器BNCTと原子炉BNCTの比較2008

    • Author(s)
      鈴木実
    • Organizer
      日本放射線腫瘍学会第21会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] IMRT、IGRT eraにおけるBNCT2008

    • Author(s)
      鈴木実
    • Organizer
      第10回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Related Report
      2008 Final Research Report
  • [Presentation] 膀胱上皮内癌に対する硼素中性子捕捉療法の提案2007

    • Author(s)
      鈴木実
    • Organizer
      第4回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      堺
    • Year and Date
      2007-08-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分布の検討 : Phase I study プロトコール作成に向けて2007

    • Author(s)
      鈴木実
    • Organizer
      第4回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      堺
    • Year and Date
      2007-08-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分布の検討:Phase I studyプロトコール作成に向けて2007

    • Author(s)
      鈴木 実、田中浩基、菓子野元郎、他4名
    • Organizer
      第4回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      堺
    • Year and Date
      2007-08-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の基礎的検討-中皮腫モデルマウスを用いて-2007

    • Author(s)
      鈴木実
    • Organizer
      第46回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      筑波
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の基礎的検討-中皮腫モデルマウスを用いて-2007

    • Author(s)
      鈴木 実、菓子野元郎、木梨友子、増永慎一郎、小野公二
    • Organizer
      第46回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      つくば
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分布の検討 : Phase I study プロトコール作成に向けて2007

    • Author(s)
      鈴木実
    • Organizer
      第42回JROG
    • Place of Presentation
      たつの
    • Year and Date
      2007-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分析の検討:Phase I studyプロトコール作成に向けて2007

    • Author(s)
      鈴木 実、田中浩基、菓子野元郎、他3名
    • Organizer
      第42回JROG
    • Place of Presentation
      龍野
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法のPhase I studyプロトコールの検討2007

    • Author(s)
      鈴木実
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      博多
    • Related Report
      2008 Final Research Report
  • [Presentation] 硼素中性子捕捉療法の体幹部腫瘍への適応拡大2007

    • Author(s)
      鈴木実
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Boron neutron capture therapy suppressed growth of orthotopic experimental malignant plural mesothelioma tumor2007

    • Author(s)
      鈴木実
    • Organizer
      The 5th Japan-US Cancer Therapy Symposium & The 5th S.Takahashi Memorial Joint Symposium
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 硼素中性子捕捉療法による悪性胸膜中皮腫に対する基礎的検討2007

    • Author(s)
      鈴木実
    • Organizer
      第13回癌治療増感研究会
    • Place of Presentation
      前橋
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 硼素中性子捕捉療法を施行した肺肉腫の1例2007

    • Author(s)
      鈴木実
    • Organizer
      第66回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 硼素中性子捕捉療法を施行した 肺肉腫の1例2007

    • Author(s)
      鈴木 実、永田憲司、木梨友子、他6名
    • Organizer
      第66回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Boron neutron capture therapy suppressed growth of orthotopic experimental malignant plural mesothelioma tumor2007

    • Author(s)
      鈴木 実、永田憲司、増永慎一郎、他3名
    • Organizer
      The 5th Japan-US Cancer Therapy Symposium & The 5th S. Takahashi Memorial Joint Symposium
    • Place of Presentation
      仙台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法のPhase I stusyプロトコールの検討2007

    • Author(s)
      鈴木 実、田中浩基、菓子野元郎、他3名
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      博多
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性胸膜中皮腫に対する新規治療法としての硼素中性子捕捉療法の可能性2006

    • Author(s)
      鈴木実
    • Organizer
      第3回日本粒子線治療臨床研究会
    • Place of Presentation
      神戸
    • Year and Date
      2006-06-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 多発肝細胞癌に硼素中性子捕捉療法(BNCT)を施行した1例2006

    • Author(s)
      鈴木実
    • Organizer
      日本放射線腫瘍学会第19回学術大会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] First attempt of boron neutron capture therapy to hepatocellular carcinoma2006

    • Author(s)
      鈴木実
    • Organizer
      12th International Conference on Neutron Capture Therapy
    • Place of Presentation
      高松
    • Related Report
      2008 Final Research Report
  • [Presentation] Feasibility of boron neutron capture therapy for malignant pleural mesothelioma from a viewpoint of dose distribution analysis2006

    • Author(s)
      鈴木実
    • Place of Presentation
      高松
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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