Boron neutron capture therapy for malignant pleural mesothelioma

• Project/Area Number: 18591379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: SUZUKI Minoru Kyoto University, 原子炉実験所・附属粒子線腫瘍学研究センター, 准教授 (00319724)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 悪性胸膜中皮腫 / 硼素中性子捕捉療法

Research Abstract

手術不能である悪性胸膜中皮腫に対する新規治療方法として、硼素中性子捕捉療法の適用が可能であるか否かの基礎的検討を実施した.悪性中皮腫モデルマウスを用いて硼素中性子捕捉療法が重篤な肺障害を与えず、中皮腫の縮小効果と生存期間を延長させることを明らかにした.また、治療計画研究を実施し正常肺への耐容線量以下で、腫瘍に対して治療効果が期待される線量を投与することが可能であることを明らかにした.

Research Products

• [Journal Article] Survival benefit of boron neutron capture therapy for recurrent malignant gliomas (2009)
  • Author(s): Miyatake SI, Kawabata S, Yokoyama K, Kuroiwa T, Michiue H, Sakurai Y, Kumada H, Suzuki M, Maruhashi A, Kirihata M, Ono K
  • Journal Title: J Neurooncol 91(2) Pages: 199-206
  • Peer Reviewed
• [Journal Article] Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma (2009)
  • Author(s): 鈴木実
  • Journal Title: Radiotherapy and Oncology
  • Peer Reviewed
• [Journal Article] Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer (2008)
  • Author(s): Fuwa N, Suzuki M, Sakurai Y, Nagata K, Kinashi Y, Masunaga S, Maruhashi A, Imahori Y, Kodaira T, Tachibana H, Nakamura T, Ono K
  • Journal Title: Br J Radiol 81(969) Pages: 749-52
  • Peer Reviewed
• [Journal Article] A novel concept of treatmentof diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT) (2008)
  • Author(s): Suzuki M, Endo K, Satoh H, Sakurai Y, Kumada H, Kimura H, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K
  • Journal Title: Radiother Oncol 88 Pages: 192-195
  • Peer Reviewed
• [Journal Article] Effect of neutron capture therapy on the cell cycle of human squamous cell carcinoma cells (2008)
  • Author(s): Kamida A, Fujita Y, Kato I, Iwai S, Ono K, Suzuki M, Sakurai Y, Yura Y
  • Journal Title: Int J Radiat Biol 84(3) Pages: 191-199
  • Peer Reviewed
• [Journal Article] Radiobiological significance of the response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with γ-rays and reactor neutron beams (2008)
  • Author(s): Masunaga S, Ando K, Uzawa K, Hirayama R, Furusawa Y, Koide S, Sakurai Y, Nagata K, Suzuki M, Kashino G, Kinashi Y, Tanaka H, Maruhashi, Ono K
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys 70(1) Pages: 221-228
  • Peer Reviewed
• [Journal Article] A novel concept of treatmentof diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT) (2008)
  • Author(s): 鈴木実
  • Journal Title: Radiotherapy and Oncology 88 Pages: 192-195
  • Peer Reviewed
• [Journal Article] Early effects of boron neutron capture therapy on rat glioma models (2007)
  • Author(s): Nakagawa N, Akai F, Fukawa N, Fujita Y, Suzuki M, Ono K, Taneda M
  • Journal Title: Brain Tumor Pathol 24(1) Pages: 7-13
  • Peer Reviewed
• [Journal Article] Boron neuron capture therapy using epithermal neutrons for recurrent cancer in the oral cavity and cervical lymph node metastasis (2007)
  • Author(s): Ariyoshi Y, Miyatake S, Kimura Y, Shimahara T, Kawabata S, Nagata K, Suzuki M, Maruhashi A, Ono K, Shimahara M
  • Journal Title: Oncol Rep 18(4) Pages: 861-866
  • Peer Reviewed
• [Journal Article] Evaluation of micronucleus induction in lymphocytes of patients following Boron-Neutron-Capture-Therapy : A comparison with thyroid cancer patients treated with radioiodine (2007)
  • Author(s): Kinashi Y, Masunaga S, Sakurai Y, Suzuki M, Nagata K, Ono K
  • Journal Title: J Radiat Res 48 Pages: 197-204
  • NAID: 110006278194
  • Peer Reviewed
• [Journal Article] The bystandar effect observed in boron neutron capture therapy : a study of the induction of mutations in the HPRT locus (2007)
  • Author(s): Kinashi Y, Masunaga S, Nagata K, Suzuki M, Takahashi S, Ono K
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys 68(2) Pages: 508-514
  • Peer Reviewed
• [Journal Article] First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma (2007)
  • Author(s): Suzuki M, Sakurai Y, Hagiwara S, Masunaga S, Kinashi Y,Nagata K, Maruhashi A, Kudo M, Ono K
  • Journal Title: Jpn J Clin Oncol 37(5) Pages: 376-81
  • Peer Reviewed
• [Journal Article] Y, Nagata K, Maruhashi A, Ono K. Preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity (2007)
  • Author(s): Suzuki M, Sakurai Y, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K
  • Journal Title: Jap J Clin Oncol 37(4) Pages: 245-249
  • Peer Reviewed
• [Journal Article] Prellminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity (2007)
  • Author(s): Suzuki M, Sakurai Y, Masunaga S, et. al.
  • Journal Title: Japanese Journal of Clinical Oncology 37 Pages: 245-249
  • Peer Reviewed
• [Journal Article] 硼素中性子捕捉療法(Boron Neutron Captufe Therapy; BNCT)の現状と将来展望-癌細胞選択照射がもたらすWhole Organ Radiotherapyの可能性- (2007)
  • Author(s): 鈴木 実, 菓子野元郎, 木梨友子, 他3名
  • Journal Title: 映像情報 39 Pages: 1126-1135
• [Journal Article] Feasibility of boron neutron capture therapy (BNCT) for malignant pleural mesothelioma from a viewpoint of dose distribution analysis (2006)
  • Author(s): Suzuki M, Sakurai Y, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys 66(5) Pages: 1584-1589
  • Peer Reviewed
• [Journal Article] The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy (2006)
  • Author(s): Masunaga S, Kasaoka S, Maruyama K, Nigg D, Sakurai Y, Nagata K, Suzuki M, Kinashi Y, Maruhashi A, Ono K
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys 66(5) Pages: 1515-1522
  • Peer Reviewed
• [Journal Article] Impact of intra-arterial administration of boron compounds on dose-volume histograms (DVHs) in boron neutron capture therapy (BNCT) for recurrent head and neck tumors (2006)
  • Author(s): Suzuki M, Sakurai Y, Nagata K, Kinashi Y, Masunaga S, Ono K, Maruhashi A, Kato I, Fuwa N, Hiratsuka J, Imahori Y
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys 66(5) Pages: 1523-1527
  • Peer Reviewed
• [Journal Article] Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma
  • Author(s): Suzuki M, Tanaka H, Sakurai Y, Kashino G, Yong L, Masunaga S, Kinashi Y, Mitsumoto T, Yajima S, Tsutsui H, Sato T, Maruhashi A, Ono K
  • Journal Title: Radiother Oncol (In press)
  • Peer Reviewed
• [Presentation] IGRT, IGRT eraにおけるBNCT-加速器中性子源開発後の先に描く将来展望 (2008)
  • Author(s): 鈴木実
  • Organizer: 第105回関西Cancer therapistの会
  • Place of Presentation: Florence (Italy)
  • Year and Date: 2008-12-03
• [Presentation] IGRT, IGRT eraにおけるBNCT-加速器中性子源開発後の先に描く将来展望- (2008)
  • Author(s): 鈴木実
  • Organizer: 第105回関西Cancer therapistの会
  • Place of Presentation: 大阪
  • Year and Date: 2008-12-03
• [Presentation] Boron neutron capture therapy (BNCT) for diffuse or multiple pleural tumors : Case reports of two cases (2008)
  • Author(s): 鈴木実
  • Organizer: 13th International Conference on Neutron Capture Therapy
  • Place of Presentation: フイレンツェ
  • Year and Date: 2008-11-04
• [Presentation] IGRT時代における硼素中性子捕捉療法(BNCT)の役割 (シンポジウム 癌の粒子線治療・各療法の特徴とその将来を展望する) (2008)
  • Author(s): 鈴木実
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] IGRT時代における硼素中性子捕捉療法(BNCT)の役割(シンポジウム癌の粒子線治療・各療法の特徴とその将来を展望する) (2008)
  • Author(s): 鈴木実
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 悪性胸膜中皮腫に対する棚素中性子捕捉療法(BNCT) : 加速器BNCTと原子炉BNCTの比較 (2008)
  • Author(s): 鈴木実
  • Organizer: 日本放射線腫瘍学会第21回学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-16
• [Presentation] 教育講演「NCTレビュー」8. 肺腫瘍・肝臓癌 (2008)
  • Author(s): 鈴木実
  • Organizer: 第5回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 倉敷
  • Year and Date: 2008-07-26
• [Presentation] 教育講演「CTレビュー」8. 肺腫瘍・肝臓癌 (2008)
  • Author(s): 鈴木実
  • Organizer: 第5回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 倉敷
  • Year and Date: 2008-07-26
• [Presentation] 加速器中性子源が硼素中性子捕捉療法に与えるimpact - 悪性胸膜中皮腫症例を中心に (2008)
  • Author(s): 鈴木実
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-06
• [Presentation] 加速器中性子源が硼素中性子捕捉療法に与えるimpact-悪性胸膜中皮腫症例を中心に- (2008)
  • Author(s): 鈴木実
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-06
• [Presentation] IMRT,IGRT era におけるBNCT (2008)
  • Author(s): 鈴木 実、菓子野元郎、木梨友子、増永慎一郎、小野公二
  • Organizer: 第10回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
  • Year and Date: 2008-02-09
• [Presentation] Boron neutron capture therapy (BNCT) for diffuse or multiple pleural tumors (2008)
  • Author(s): 鈴木実
  • Organizer: Case reports of two cases. 13th International Conference on Neutron Capture Therapy
  • Place of Presentation: 大阪
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法(BNCT) : 加速器BNCTと原子炉BNCTの比較 (2008)
  • Author(s): 鈴木実
  • Organizer: 日本放射線腫瘍学会第21会学術大会
  • Place of Presentation: 札幌
• [Presentation] IMRT、IGRT eraにおけるBNCT (2008)
  • Author(s): 鈴木実
  • Organizer: 第10回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
• [Presentation] 膀胱上皮内癌に対する硼素中性子捕捉療法の提案 (2007)
  • Author(s): 鈴木実
  • Organizer: 第4回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 堺
  • Year and Date: 2007-08-26
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分布の検討 : Phase I study プロトコール作成に向けて (2007)
  • Author(s): 鈴木実
  • Organizer: 第4回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 堺
  • Year and Date: 2007-08-26
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分布の検討:Phase I studyプロトコール作成に向けて (2007)
  • Author(s): 鈴木 実、田中浩基、菓子野元郎、他4名
  • Organizer: 第4回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 堺
  • Year and Date: 2007-08-26
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の基礎的検討-中皮腫モデルマウスを用いて- (2007)
  • Author(s): 鈴木実
  • Organizer: 第46回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 筑波
  • Year and Date: 2007-07-21
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の基礎的検討-中皮腫モデルマウスを用いて- (2007)
  • Author(s): 鈴木 実、菓子野元郎、木梨友子、増永慎一郎、小野公二
  • Organizer: 第46回日本医学放射線学会生物部会学術大会
  • Place of Presentation: つくば
  • Year and Date: 2007-07-21
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分布の検討 : Phase I study プロトコール作成に向けて (2007)
  • Author(s): 鈴木実
  • Organizer: 第42回JROG
  • Place of Presentation: たつの
  • Year and Date: 2007-06-30
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法の線量分析の検討:Phase I studyプロトコール作成に向けて (2007)
  • Author(s): 鈴木 実、田中浩基、菓子野元郎、他3名
  • Organizer: 第42回JROG
  • Place of Presentation: 龍野
  • Year and Date: 2007-06-30
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法のPhase I studyプロトコールの検討 (2007)
  • Author(s): 鈴木実
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 博多
• [Presentation] 硼素中性子捕捉療法の体幹部腫瘍への適応拡大 (2007)
  • Author(s): 鈴木実
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
• [Presentation] Boron neutron capture therapy suppressed growth of orthotopic experimental malignant plural mesothelioma tumor (2007)
  • Author(s): 鈴木実
  • Organizer: The 5th Japan-US Cancer Therapy Symposium & The 5th S.Takahashi Memorial Joint Symposium
  • Place of Presentation: 仙台
• [Presentation] 硼素中性子捕捉療法による悪性胸膜中皮腫に対する基礎的検討 (2007)
  • Author(s): 鈴木実
  • Organizer: 第13回癌治療増感研究会
  • Place of Presentation: 前橋
• [Presentation] 硼素中性子捕捉療法を施行した肺肉腫の1例 (2007)
  • Author(s): 鈴木実
  • Organizer: 第66回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] 硼素中性子捕捉療法を施行した 肺肉腫の1例 (2007)
  • Author(s): 鈴木 実、永田憲司、木梨友子、他6名
  • Organizer: 第66回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] Boron neutron capture therapy suppressed growth of orthotopic experimental malignant plural mesothelioma tumor (2007)
  • Author(s): 鈴木 実、永田憲司、増永慎一郎、他3名
  • Organizer: The 5th Japan-US Cancer Therapy Symposium & The 5th S. Takahashi Memorial Joint Symposium
  • Place of Presentation: 仙台
• [Presentation] 悪性胸膜中皮腫に対する硼素中性子捕捉療法のPhase I stusyプロトコールの検討 (2007)
  • Author(s): 鈴木 実、田中浩基、菓子野元郎、他3名
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 博多
• [Presentation] 悪性胸膜中皮腫に対する新規治療法としての硼素中性子捕捉療法の可能性 (2006)
  • Author(s): 鈴木実
  • Organizer: 第3回日本粒子線治療臨床研究会
  • Place of Presentation: 神戸
  • Year and Date: 2006-06-23
• [Presentation] 多発肝細胞癌に硼素中性子捕捉療法(BNCT)を施行した1例 (2006)
  • Author(s): 鈴木実
  • Organizer: 日本放射線腫瘍学会第19回学術大会
  • Place of Presentation: 仙台
• [Presentation] First attempt of boron neutron capture therapy to hepatocellular carcinoma (2006)
  • Author(s): 鈴木実
  • Organizer: 12th International Conference on Neutron Capture Therapy
  • Place of Presentation: 高松
• [Presentation] Feasibility of boron neutron capture therapy for malignant pleural mesothelioma from a viewpoint of dose distribution analysis (2006)
  • Author(s): 鈴木実
  • Place of Presentation: 高松