| Budget Amount *help |
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Research Abstract |
The use of tirapazamine (TPZ), especially when administered continuously, combined with reduced dose-rate irradiation (RDR), is useful for suppressing the reduction in the sensitivity of tumor cells caused by the decrease in irradiation dose rate in vivo whether under gamma-ray or reactor neutron beam irradiation. Especially in combination with mild temperature hyperthermia (MTH), the effect by TPZ suppressing the reduction in the sensitivity was further increased P53-mutated tumors showed little repair capacity by leaving an interval between high dose-rate irradiation (HDR) and the assay and decreasing the irradiation dose rate. MTH and wortmannin treatment in combination with G-ray irradiation is thought to be useful for suppressing the recovery of radiation-induced damage, since the recovery was considered to be mainly due to non-homologous end joining repair. Following vascular disrupting agent ZD6126 treatment, in terms of tumor control, intratumor physiologic factors such as the size of the HE, depending on the time after ZD6126 injection, have to be taken into account when combining another treatment with ZD6126. MTH was very effective in combination with the newly-developed ^10B-carrier TX-2100. The sensitizing effect in combination with MTH should be examined when new ^10B-carriers are designed. In terms of biodistribution characteristics and tumor cell-killing effect as a whole, including quiescent cells, decahydrodecaborate-^10B transferrin (TF)-pendant-type polyethyleneglycol (PEG) liposomes were regarded as more promising KB-carriers than borocaptate-^10B-encapsulating liposomes. In terms of tumor cell-killing effect as a whole, including quiescent cells, accelerated carbon ion beams, especially with higher linear energy transfer values, are very useful for suppressing the dependency on the heterogeneity within solid tumors as well as depositing radiation dose precisely.
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