Analysis of the effect of reduced dose rate and fractionated irradiation, including the effectoniniraturnor quiescent cells

• Project/Area Number: 18591380
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MASUNAGA Shinichiro Kyoto University, Research Reactor Institute, Associate Professor (80238914)
• Co-Investigator(Kenkyū-buntansha): SAKURAI Yoshinori Sapporo Medical School of miedicine, 医学部, Lecturer (20273534) ; TANO Keizo Kyoto University, Research Reactor Institute, Associate Professor (00183468)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: Quieseent cell / Reduced dose-rate irradiation / Hypoxic cell cytotoxin / Mild temperature hyperthermia / transferrin-pendant-type polyethyleneaqlycol liposome / Newly-developed ^<10>B-carrier / Accelerated carbon ion beam irradiation / Non-homologous end joining repair / 潜在的致死的障害からの回復 / 線量率効果 / 非相同末端結合 / 高LET放射線 / 原子炉中性子線照射 / 照射線量率効果 / 低酸素特異的細胞毒 / 連続的皮下投与 / 中性子捕捉療法 / 血管標的物質 / トランスフェリン結合PEGリポソーム

Research Abstract

The use of tirapazamine (TPZ), especially when administered continuously, combined with reduced dose-rate irradiation (RDR), is useful for suppressing the reduction in the sensitivity of tumor cells caused by the decrease in irradiation dose rate in vivo whether under gamma-ray or reactor neutron beam irradiation. Especially in combination with mild temperature hyperthermia (MTH), the effect by TPZ suppressing the reduction in the sensitivity was further increased P53-mutated tumors showed little repair capacity by leaving an interval between high dose-rate irradiation (HDR) and the assay and decreasing the irradiation dose rate. MTH and wortmannin treatment in combination with G-ray irradiation is thought to be useful for suppressing the recovery of radiation-induced damage, since the recovery was considered to be mainly due to non-homologous end joining repair. Following vascular disrupting agent ZD6126 treatment, in terms of tumor control, intratumor physiologic factors such as the size of the HE, depending on the time after ZD6126 injection, have to be taken into account when combining another treatment with ZD6126. MTH was very effective in combination with the newly-developed ^10B-carrier TX-2100. The sensitizing effect in combination with MTH should be examined when new ^10B-carriers are designed. In terms of biodistribution characteristics and tumor cell-killing effect as a whole, including quiescent cells, decahydrodecaborate-^10B transferrin (TF)-pendant-type polyethyleneglycol (PEG) liposomes were regarded as more promising KB-carriers than borocaptate-^10B-encapsulating liposomes. In terms of tumor cell-killing effect as a whole, including quiescent cells, accelerated carbon ion beams, especially with higher linear energy transfer values, are very useful for suppressing the dependency on the heterogeneity within solid tumors as well as depositing radiation dose precisely.

Research Products

• [Journal Article] Radiobiological significance of the response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with gamma-rays and reactor neutron beams. (2008)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, et. al.
  • Journal Title: International Journal of Radiation Oncology Biology Physics 70(1) Pages: 221-228
  • NAID: 130007001332
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy. (2008)
  • Author(s): Fujii H, Sakata K, Katsumata Y, Sato R, Kinouchi M, Someya M, Masunaga S, Hareyama M and Hirata H.
  • Journal Title: Radiotherapy and Oncology 86 Pages: 354-360
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Radiobiological significance of the response of intratumor quiescent cells at vivo to accelerated carbon ion beams compared with gamma-rays and reactor neutron beams (2008)
  • Author(s): Masunaga, S., Ando, K., Uzawa, A., Hirayama, R., Furusawa, Y., Sakurai, Y., Nagata, K., Suzuki, M., Kashino, Q., Kinashi, Y., Tanaka, H., Maruhashi, A., Ono, K
  • Journal Title: Int J Radial Oncol Biol Phys 70(1) Pages: 221-228
  • NAID: 130007001332
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The radiosensitivity of total and quiescent cell populations in solidtumors to 290 MeV/u carbon ion beam irradiation in vivo. (2008)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, et. al.
  • Journal Title: Acta Oncologica (in press)
  • Peer Reviewed
• [Journal Article] Tissue oxygenation in a murine SCC VII tumor after X-rayirradiation as determined by EPR spectroscopy. (2008)
  • Author(s): Fujii H, Sakata K, Katsumata Y, Sato R, Kinouchi M, Someya M, Masunaga S, Hareyama M and Hirata H.
  • Journal Title: Radiotherapy and Oncology 86 Pages: 354-360
  • Peer Reviewed
• [Journal Article] Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells. (2007)
  • Author(s): Masunaga S, Nagasawa H, Nagata K, Suzuki M, Uto Y, Hori H, et. al.
  • Journal Title: Journal of Cancer Research and Clinical Oncology 133(1) Pages: 47-55
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays. (2007)
  • Author(s): Masunaga S, Nagasawa H, Uto Y, Hori H, Nagata K, Suzuki M, et. al.
  • Journal Title: International Journal of Hyperthermia 23(1) Pages: 29-35
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibition of repair from radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. (2007)
  • Author(s): Masunaga S, Nagata K, Suzuki M, Kashino G, Kinashi Y and Ono K.
  • Journal Title: Radiation Medicine 25 Pages: 417-425
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cells. (2007)
  • Author(s): Masunaga S, Takahashi A, Ohnishi K, Nagata K, et. al.
  • Journal Title: Oncology Report 18 Pages: 1589-1596
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efficacy of Mild Temperature Hyperthermia in Combined Treatments for Cancer Therapy. (2007)
  • Author(s): Masunaga S, Nishimura Y, Hiraoka M, Abe M, Takahashi M and Ono K
  • Journal Title: Thermal Medicine 23 Pages: 103-112
  • NAID: 10029676999
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells (2007)
  • Author(s): Masunaga, S., Nagasawa, H., Nagata, K., Suzuki, M., Uto, Y., Hod, H., Kinashi, Ono, K
  • Journal Title: J Cancer Res Clin Oncol 133(1) Pages: 47-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose rate irradiation with gamma-rays (2007)
  • Author(s): Masunaga, S., Nagasawa, H., Uto, Y., Hori, H., Nagata, K., Suzuki, M., Kinashi, Y., Ono, K
  • Journal Title: Int J Hyperthermia 13(1) Pages: 29-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of repair from radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations (2007)
  • Author(s): Masunaga, S., Nagata, K., Suzuki, M., Kashino, Q., Kinashi, Y., Ono, K
  • Journal Title: Radiat Med 25 Pages: 417-425
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dependency of repair of radiation-induced damage on p53status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cells (2007)
  • Author(s): Masunaga, S., Takahashi, A., Ohnishi, K., Nagata, K., Suzuki, M., Kashino, Q., Kinashi, Y., Ohnishi, T., Ono, K
  • Journal Title: Oncol Rep 18 Pages: 1589-1596
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficacy of Mild Temperature Hyperthermia in Combined Treatments for Cancer Therapy (2007)
  • Author(s): Masunaga, S., Nishimura, Y., Hiraoka, M., Abe, M., Takahashi, M., Ono, K
  • Journal Title: Thermal Med 13 Pages: 103-112
  • NAID: 10029676999
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dependency of repair of radiation-induced damage on p53 status and efficient inhihition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cells. (2007)
  • Author(s): Masunaga S, Takahashi A, Ohnishi K, Nagata K, et. al.
  • Journal Title: Oncology Report 18 Pages: 1589-1596
  • Peer Reviewed
• [Journal Article] Efficacy of Mild Temperature Hyperthermia in Combined Treatments for Cancer Therapy. (2007)
  • Author(s): Masunaga S, Nishimura Y, Hiraoka M, Abe M, Takahashi M and Ono K.
  • Journal Title: Thermal Medicine 23 Pages: 103-112
  • NAID: 10029676999
  • Peer Reviewed
• [Journal Article] Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells. (2007)
  • Author(s): Masunaga S, Nagasawa H, Nagata K, Suzuki M., Uto Y., Hori H. et al.
  • Journal Title: Journal of Cancer Research and Clinical Oncology 133・1 Pages: 47-55
• [Journal Article] The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays. (2007)
  • Author(s): Masunaga S, Nagasawa H, Uto Y, Hori H, Nagata K., Suzuki M. et al.
  • Journal Title: International Journal of Hyperthermia 23・1 Pages: 29-35
• [Journal Article] The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy. (2006)
  • Author(s): Masunaga S, Nagasawa H, Sakurai Y, Uto Y, et. al.
  • Journal Title: International Journal of Hyperthermia 22(4) Pages: 287-299
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahyd rodecaborate-10B(GB-10)as 10B-carriers for boron neutron capture therapy. (2006)
  • Author(s): Masunaga S, Kasaoka S, Maruyama K, Nigg D, Sakurai Y, et. al.
  • Journal Title: International Journal of Radiation Oncology Biology Physics 66(5) Pages: 1515-1522
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transferrin-loaded nido-carborane liposomes: tumor-targeting boron delivery system for neutron capture therapy. (2006)
  • Author(s): Miyajima Y, Nakamura H, Kuwata Y, Lee JD, Masunaga S, Ono K, et. al.
  • Journal Title: Bioconjugational Chemistry 17(5) Pages: 1314-1320
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons, with reference to the effects on quiescent tumor cell populations. (2006)
  • Author(s): Masunaga S, Sakurai Y, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, et. al.
  • Journal Title: British Journal of Radiology 79 Pages: 991-998
  • NAID: 130007001336
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy (2006)
  • Author(s): Masunaga, S., Nagasawa, H., Sakurai, Y., Uto, Y., Hori, H., Nagata, K., Suzuki, M., Maruhashi, A., Kinashi, Y., Ono, K
  • Journal Title: Int J Hyperthermia 22(4) Pages: 287-299
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons, with reference to the effects on quiescent tumor cell populations (2006)
  • Author(s): Masunaga, S., Sakurai, Y., Nagata, K., Suzuki, M., Maruhashi, A., Kinashi, Y. Nagasawa, H., Uto, Y., Hod, H., Ono, K
  • Journal Title: Br J Radiol 79 Pages: 991-998
  • NAID: 130007001336
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy (2006)
  • Author(s): Masunaga, S., Kasaoka, S., Mamyama, K., Nigg, D., Sakurai, Y., Nagata, K., Suzuki, M., Kinashi, Y., Maruhashi, A., One, K
  • Journal Title: Int J Radiat Oncol Biol Phys 66(5) Pages: 1515-1522
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy. (2006)
  • Author(s): Masunaga S, Nagasawa H, Sakurai Y, Uto Y, Hori H, Nagata K, et al.
  • Journal Title: International Journal of Hyperthermia 22・4 Pages: 287-299
• [Journal Article] The potential of transferrin-pendant type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron cature therapy. (2006)
  • Author(s): Masunaga S, Kasaoka S, Maruyama K, Nigg D, Sakurai Y, Nagata K, et al.
  • Journal Title: International Journal of Radiation Oncology Biology Physics 66・5 Pages: 1515-1522
• [Journal Article] Transferrin-loaded nido-carborane liposomes : tumor-targeting boron delivery system for neutron capture therapy. (2006)
  • Author(s): Miyajima Y, Nakamura H, Kuwata Y, Lee JD, Masunaga S, Ono K, et al.
  • Journal Title: Bioconjugational Chemistry 17・5 Pages: 1314-1320
• [Journal Article] The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using gamma-rays or reactor thermal neutrons, with reference to the effects on quiescent tumor cell populations. (2006)
  • Author(s): Masunaga S, Sakurai Y, Nagata K, Suzuki M, Maruhashi A, Kinashi Y, et al.
  • Journal Title: British Journal of Radiology 79 Pages: 991-998
  • NAID: 130007001336
• [Journal Article] The radiosensitivity of total and quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo.
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, et. al.
  • Journal Title: Acta Oncologica (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The radiosensitivity of total and quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo
  • Author(s): Masunaga, S., Ando, K., Uzawa, A., Hirayama, R., Furusawa, Y., Koike, S., Ono, K
  • Journal Title: Acta Oncol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 休止期細胞反応も加味した加速炭素イオン線高線量率照射の抗腫瘍効果 (2007)
  • Author(s): 増永慎一郎、鵜澤玲子、平山亮一、安藤興一、古澤佳也、永田憲司、鈴木 実、菓子野元郎、木梨友子、小野公二
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-12-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The Responses of Intratumor Total and Quiescent Cell Populations to 290 MeV/u Carbon Ion Beam Irradiation in vivo. (2007)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Koike S, Furusawa Y, Ono K
  • Organizer: The 93th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Mc Cormick Place, Chicago
  • Year and Date: 2007-11-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The Responses of Intratumor Total and Quiescent Cell Populations to 290 MeV/u Carbon Ion Beam Irradiation in vivo. (2007)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Koike S, Furusawa Y, Ono K
  • Organizer: The 93th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: McCormick Place, Chicago
  • Year and Date: 2007-11-25
• [Presentation] γ線及び原子炉中性子線照射と比較した休止期腫瘍細胞反応を加味した加速炭素イオン線照射の抗腫瘍効果解析 (2007)
  • Author(s): 増永慎一郎、櫻井良憲、他
  • Organizer: 日本放射線影響学会第50回大会
  • Place of Presentation: 幕張国際会議場
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低減線量率γ線照射下における低温度温熱処置併用連続的Tirapazamine投与の有用性 (2007)
  • Author(s): 増永慎一郎、永澤秀子、他
  • Organizer: 第45回日本癌治療学会学術総会
  • Place of Presentation: 京都国際会議場.
  • Year and Date: 2007-10-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低減線量率γ線照射下における低温度温熱処置併用連続的Tirapazamine投与の有用性 (2007)
  • Author(s): 増永慎一郎、永澤秀子、宇都義浩、堀 均、永田憲司、鈴木実、菓子野元郎、木梨友子、小野公二
  • Organizer: 第45回日本癌治療学会学術総会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2007-10-24
• [Presentation] The responses of total and quiescent cell populations within solid tumors to 290 MeV/u carbon ion beams in vivo. (2007)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Furusawa Y, Koike S, Ono K
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The responses of quiescent cell populations in solid tumors to 290 MeV/u carbonion beam irradiation in vivo, compared with those of total cell populstions. (2007)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Koike S, Furusawa Y, Ono K
  • Organizer: The 14th European Cancer Conference(ECCO 14)
  • Place of Presentation: Barcelona International Convention Center
  • Year and Date: 2007-09-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The responses of quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo, compared with those of total cell populations. (2007)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Koike S, Furusawa Y, Ono K
  • Organizer: The 14th European Cancer Conference (ECCO 14)
  • Place of Presentation: Barcelona International
  • Year and Date: 2007-09-26
• [Presentation] 低減線量率γ線照射下における連続的Tirapazamine投与時に併用された低温度温熱処置の有用性 (2007)
  • Author(s): 増永慎一郎、永澤秀子、他
  • Organizer: 日本ハイパーサーミア学会第23回大会
  • Place of Presentation: 前橋テルサ
  • Year and Date: 2007-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低減線量率γ線照射において低温度温熱処置とTirapazamine連続的投与を併用する有用性についての検討 (2007)
  • Author(s): 増永慎一郎、永澤秀子、他
  • Organizer: 第46回日本医学放射線学会生物部会学術集会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2007-07-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inhibition of repair of radiation-induced damage by mild hyperthermia with reference to the effect on quiescent cells in solid tumors. (2007)
  • Author(s): Masunaga S, Nagata K, Suzuki M, Kashino G, Kinashi Y and Ono K.
  • Organizer: The 13th International Congress of Radiation Research
  • Place of Presentation: Marriott hotel, San Francisco
  • Year and Date: 2007-07-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低温度温熱処置は固形腫瘍特に休止期腫瘍細胞における放射線障害からの回復を効率良く抑える。 (2007)
  • Author(s): 増永慎一郎、永田憲司、鈴木実、菓子野元郎、木梨友子、小野公二
  • Organizer: 日本医学放射線学会第66回学術発表会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-04-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy (2007)
  • Author(s): Fujii, H., Sakata, K., Katsumata, Y., Sato, R., Kinouchi, M., Bomeya, M., Masunaga, S., Hareyama, M., Hirata, H
  • Organizer: EPR(Electronparamagnehciesonance2077
  • Place of Presentation: Chicago, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Inhibition of repair of radiation-induced damage by mild hyperthermia with reference to the effect on quiescent cells in solid tumors (2007)
  • Author(s): Masunaga, S., Nagata, K., Suzuki, M., Kashino, G., Kinashi, Y., Ono, K
  • Organizer: 13thInternatornal Congess of Radration Research
  • Place of Presentation: SanFranoisco, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Research of boron neutron capture therapy (BNCT) for cancer at Kyoto University Reactor (KUR) (2007)
  • Author(s): Ono, K., Masunaga, S., Suzuki, M., Nagata, K., Kinashi, Y., Maruhashi, A., Sakurai, Y., Miyatake, S., Hiratsuka, I., Kato, I
  • Organizer: 13thIternatornal Cogess of Radiaion Research
  • Place of Presentation: Sanfiancisco, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The responses of quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo, compared with those of total cell populstions (2007)
  • Author(s): Masunaga, S., Ando, K., Uzawa, A., Hirayama, R., Koike, S., Furusawa, Y., Ono, K
  • Organizer: 14th Enropean Cancer Conference (BCOC14)
  • Place of Presentation: Barceora, Spah
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The Responses Of Quiescent Cell Populations In Solid Tumors To 290 Mev/u Carbon Ion Beam Irradiation in vivo, Compared With Those Of Total Cell Populations (2007)
  • Author(s): Masunaga, S., Ando, K., Uzawa, A., Hirayama, R., Koike, S., Furusawa, Y., Ono, K
  • Organizer: 49thanrnal Meeting ofthe American Socety for Therpeutc Radiologyand Ornoology
  • Place of Presentation: Losangeles CA, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The Responses of Intratumor Total and Quiescent Cell Populations to 290 MeV/u Carbon Ion Beam Irradiation in vivo (2007)
  • Author(s): Masunaga, S., Ando, K., Uzawa, A., Hirayama, R., Koike, S., Furusawa, Y., Ono, K
  • Organizer: 93rd scientifc Assenbly and Amrual Meeting of the Radiologicai Society of Noth Ameirca
  • Place of Presentation: chicago, IL, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Tirapazamine投与及びγ線照射感受性に対する血管標的物質ZD6126投与による影響は投与後の経過時間と腫瘍の大きさに依存する (2006)
  • Author(s): 増永慎一郎、永澤秀子、他
  • Organizer: 日本放射線腫瘍学会第19回学術大会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2006-11-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The usefulness of tirapazamine combined with reduced dose rate irradiation using gamma-rays or reactor neutrons, referring to the effects on intratumor quiescent tumor cells. (2006)
  • Author(s): Masunaga S, Sakurai Y, et. al.
  • Organizer: the 12th International Congress on Neutron Capture Therapy, October, 8-13, 2006, Takamatsu, Japan.
  • Place of Presentation: 香川国際会議場
  • Year and Date: 2006-10-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Quality of hyperthermia has an impact on sequencing heating and radiotherapy. (2006)
  • Author(s): MASUNAGA S, NISHIMURA Y, HIRAOKA M and ONO K
  • Organizer: the 4th Asian Congress of Hyperthermic Oncology(ACHO), Nara City, Japan
  • Place of Presentation: 奈良県新公会堂
  • Year and Date: 2006-09-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B-carrier, TX-2100, for boron neutron capture therapy (2006)
  • Author(s): Masunaga S, Sakurai Y, et. al.
  • Organizer: the 4th Asian Congress of Hyperthermic Oncology(ACHO), Nara City, Japan
  • Place of Presentation: 奈良県新公会堂
  • Year and Date: 2006-09-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低〜中線量率γ線又は原子炉熱中性子線照射時における低酸素細胞毒投与併用の意義 (2006)
  • Author(s): 増永慎一郎、櫻井良憲、 他
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 北海道大学高等教育機能開発総合センター
  • Year and Date: 2006-09-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低〜中線量率照射時における低酸素細胞毒投与併用の意義について (2006)
  • Author(s): 増永慎一郎、櫻井良憲、 他
  • Organizer: 日本医学放射線学会第65回総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2006-04-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Dose Estimation in Neutron Capture Therapy for Liver Tumors (2006)
  • Author(s): Sakurai, Y., Suzuki, M., Maruhashi, A., Nagata, K., Masunaga, S., Kinashi, Y., Ono, K
  • Organizer: Wedd Congesscn Medcal Physicsand Biomedral Engineeiing
  • Place of Presentation: Sed,Korea
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Quality of hyperthermia has animpact on sequencing heating and radiotherapy (2006)
  • Author(s): Masunaga, S., Nishimura, Y., Hiraoka, M., Oho, K
  • Organizer: 4th AsianCongess of Hype the mic Oncology(ACHO), na
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The usefulness of mild temperature hyperthermia combined with a newly-developed hypoxia-oriented 10B-carrier, TX-2100, for boron neutron capture therapy (2006)
  • Author(s): Masunaga, S., Nagasawa, H., Sakurai, Y., Uto, Y., Hod, H., Nagata, K., Suzuki, M., Ono, K
  • Organizer: 4th Asin Cagess of Hypthemic Congy(ACHO)Nara city japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neutron irradiation under continuous EP injection for solving the problem of heterogeneous distribution of EPA (2006)
  • Author(s): Ono, K., Mastmaga, S., Kinashi, Y., Nagata, K., Suzuki, M., Sakurai, Y., Maruhashi, A., Kato, L., Nakazawa, M., Ariyoshi, Y., Kimura, Y
  • Organizer: 12thIntematicnal Congess on Neutron Capture Thespy
  • Place of Presentation: Takamatsu, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The usefulness of tirapazamine combined with reduced dose rate irradiation using gamma-rays or reactor neutrons, referring to the effects on intratumor quiescent tumor cells (2006)
  • Author(s): Masunaga, S., Sakurai, Y., Nagata, K., Suzuki, M., Maruhashi, A., Kinashi, Y., Nagasawa, H., Uto, Y., Hori, H., Ono, K
  • Organizer: 12th Intemcoticnal Congress on NatronCapture Theapy
  • Place of Presentation: Takamatsu, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] サーモトロンRF-8で上手に加温しよう (2006)
  • Author(s): 増永 慎一郎
  • Total Pages: 40
  • Publisher: 健康新聞社
  • Description: 「研究成果報告書概要(和文)」より