Transarterial Infusion of Radioactive Y_2O_3, Microspheres in Transplanted Liver Tumors Rabbits

• Project/Area Number: 18591381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center (2007-2008); Kyoto University (2006)
• Principal Investigator: ARAKI Norio Department of Clinical Research, National Hospital Organization Kyoto Medical Center, 臨床研究企画運営部, 研究員 (20362486)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Takayuki 金沢大学, 自然科学研究科, 特任教授 (20396956) ; NAGATA Yasushi 広島大学病院, 教授 (10228033) ; MITUMORI Michihide 京都大学, 医学研究科, 准教授 (10263089)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,970,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥570,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 放射性微小球 / 内照射療法 / 肝腫瘍 / 動脈塞栓術 / ピーグル犬 / 日本白色家兎 / ビーグル犬

Research Abstract

実験動物肝内に直径20-30μmのイットリウム微小球を経カテーテル的に注入し、肝内分布および他臓器への逸脱を評価し、血液学的な評価も同時に行い安全性も検討した。また小径微小球として、15-20μmの微小球を用いた検討でも、同様の評価を行った。

Research Products

• [Journal Article] In vitro heat generation by ferrimagnetic maghemite microspheres for hyperthermic treatment of cancer under an alternating magnetic field (2008)
  • Author(s): Kawashita M, Domi S, Saito Y, Aoki M, Ebisawa Y, Kokubo T, Saito T, Takano M, Araki N, Hiraoka M
  • Journal Title: J Mater Sci Mater Med. 19(5) Pages: 1897-903
  • Peer Reviewed
• [Journal Article] In vitro heat generation by ferrimagnetic maghemite microspheres for hyperthermic treatment of cancer under an alternating magnetic field (2008)
  • Author(s): Masakazu Kawashita, Shinjiro Domi, Yasuhiro Saito, Masaaki Aoki, Yukihiro Ebisawa, Tadashi Kokubo, Takashi Saito, Mikio Takano, Norio Araki, Masahiro Hiraoka
  • Journal Title: J Mater Sci : Mater Med 19(5) Pages: 1897-1903
  • Peer Reviewed
• [Journal Article] In vitro heat generation by ferrimagnetic maghemite microspheres for hyperthermic treatment of cancer under an alternating magnetic field. (2008)
  • Author(s): Kawashita M, Domi S, Saito Y, Aoki M, Ebisawa Y, Kokubo T, Saito T, Takano M, Araki N, Hiraoka M.
  • Journal Title: J Mater Sci Mater Med. 19(5) Pages: 1897-903
  • Peer Reviewed