Study of biological and physiological parameters predicting lung toxicity after stereotactic body radiotherapy for lung cancer

• Project/Area Number: 18591384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: SHIOYAMA Yoshiyuki Kyushu University, 大学院・医学研究院, 講師 (10323304)
• Co-Investigator(Kenkyū-buntansha): OHGA Saiji 九州大学, 大学病院, 助教 (90380427) ; HONDA Hiroshi 九州大学, 大学院・医学研究院, 教授 (90145433) ; NAKAMURA Katsumasa 九州大学, 大学病院・別府先進医療センター, 准教授 (20284507)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,190,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥690,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 肺癌 / 放射線 / 定位照射 / 肺毒性 / 先行指標 / 放射線治療

Research Abstract

This study showed that the symptomatic radiation pneumonitis (RP) were observed 10% of patients treated with stereotactic body radiotherapy (SBRT) for lung tumors. Furthermore, majority of symptomatic RP tends to develop within six months after completion of SBRT. Regarding risk factors, pretreatment serum levels of KL-6 and SP-D n addition to gender and the size of planning target volume (PTV), were suggested useful biological predictors for estimating the risk of grade 2 or greater radiation pneumonitis after SBRT for lung tumors.

Research Products

• [Journal Article] Corrugated Fiberboard as a Positioning Insert for Patients Undergoing Radiotherapy. (2010)
  • Author(s): Nakamura K, Yoshikawa H, Akai T, Nomoto S, Shioyama Y, Kuwabara Y, Yoshimitsu K.
  • Journal Title: J Radiat Res 51 Pages: 87-90
  • NAID: 10025914241
  • Peer Reviewed
• [Journal Article] Spontaneous pneumothorax after stereotactic radiotherapy for non-small-cell lung cancer. (2009)
  • Author(s): Ohnishi K, Shioyama Y, Nomoto S, Sasaki T, Ohga S, Yoshitake T, Toba T, Atsumi K, Shiinoki T, Terashima H, Honda H.
  • Journal Title: Jpn J Radiol 27(7) Pages: 269-274
  • NAID: 50007342469
  • Peer Reviewed
• [Journal Article] A clinical evaluation of visual feedback-guided breath-hold reproducibility of tumor location. Phys. (2009)
  • Author(s): Yoshitake T, Shioyama Y, Nakamura K, Ohga S, Nonoshita T, Ohnishi K, Terashima K, Arimura H, Hirata H, Honda H.
  • Journal Title: Med. Biol 54 Pages: 7171-7182
  • Peer Reviewed
• [Journal Article] 放射線治療:根治から症状緩和まで-集学的治療の一部として不可欠な領域1 (2009)
  • Author(s): 塩山善之
  • Journal Title: 肺癌-治療学 43(7) Pages: 59-64
• [Journal Article] Computerized method for estimation of the location of a lung tumor on EPID cine images without implanted markers in stereotactic body radiotherapy. (2009)
  • Author(s): Arimura H, Egashira Y, Shioyama Y, Nakamura K, Yoshidome S, Anai S, Nomoto S, Honda H, Toyofuku F, Higashida Y, Onizuka Y, Terashima H.
  • Journal Title: Phys Med Biol 54(3) Pages: 665-677
  • Peer Reviewed
• [Journal Article] Spontaneous pneumothorax after stereotactic radiotherapy for non-small-cell lung cancer (2009)
  • Author(s): Ohnishi K, Shioyama Y, Nomoto S, et al.
  • Journal Title: Jpn J Radiol. 27(7) Pages: 269-274
  • NAID: 50007342469
  • Peer Reviewed
• [Journal Article] A clinical evaluation of visual feedback-guided breath-hold reproducibility of tumor location (2009)
  • Author(s): Yoshitake T, Shioyama Y, Nakamura K, et al.
  • Journal Title: Phys.Med.Biol. 54 Pages: 7171-7182
  • Peer Reviewed
• [Journal Article] 放射線治療:根治から症状緩和まで-集学的治療の一部として不可欠な領域1肺癌 (2009)
  • Author(s): 塩山善之
  • Journal Title: 治療学 43(7) Pages: 59-64
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 塩山善之
  • Journal Title: 肺がん薬物療法Q&A臨床現場での考え方(中西洋一編)(南江堂) Pages: 75-77
• [Journal Article] Computerized method for estimation of the location of a lung tumor on EPID cine images without implanted markers in stereotactic body radiotherapy (2009)
  • Author(s): Arimura H, Egashira Y, Shioyama Y, Nakamura K, Yoshidome S, Anai S, Nomoto S, Honda H, Toyofuku F, Higashida Y, Onizuka Y, Terashima H
  • Journal Title: Phys Med Biol 54(3) Pages: 665-677
  • Peer Reviewed
• [Journal Article] Computerized method for estimation of the location of a lung tumor on EPID cine images without implanted markers in stereotactic body radiotherapy (2009)
  • Author(s): Arimura H, Egashira Y, Shioyama Y, et al.
  • Journal Title: Phys Med Biol 54(3) Pages: 665-667
  • Peer Reviewed
• [Journal Article] Breath-hold monitoring and visual feedback for radiotherapy using a charge-coupled device camera and a head-mounted display: system development and feasibility. (2008)
  • Author(s): Yoshitake T, Nakamura K, Shioyama Y, Nomoto S, Ohga S, Toba T, Shiinoki T, Anai S, Terashima H, Kishimoto J, Honda H.
  • Journal Title: Radiat Med 26 Pages: 50-55
  • NAID: 10024137846
  • Peer Reviewed
• [Journal Article] 放射線治療の発達:特に肺癌に対する定位放射線照射の応用について. (2008)
  • Author(s): 寺嶋廣美, 塩山善之, 野元諭, 大賀才路, 吉武忠正, 鳥羽隆史, 渥美和重, 大西かよ子, 本田浩
  • Journal Title: 福岡医学会雑誌 99巻 Pages: 1-6
  • NAID: 120000985143
• [Journal Article] Breath-hold monitoring and visual feedback for radiotherapy using a charge-coupled device camera and a head-mounted display: system development and feasibility (2008)
  • Author(s): Yoshitake T, Nakamura K, Shioyama Y, Nomoto S, Ohga S, Toba T, Shiinoki T, Anai S, Terashima H, Kishimoto J, Honda H
  • Journal Title: Radiat Med 26 Pages: 50-55
  • NAID: 10024137846
  • Peer Reviewed
• [Journal Article] 放射線治療の発達 : 特に肺癌に対する定位放射線照射の応用について (2008)
  • Author(s): 寺嶋廣美、塩山善之、野元 諭、大賀才路、吉武忠正、鳥羽隆史、渥美和重、大西かよ子、本田 浩
  • Journal Title: 福岡医学会雑誌 99巻 Pages: 1-6
  • NAID: 120000985143
• [Journal Article] 放射線治療の発達:特に肺癌に対する定位放射線照射の応用について (2008)
  • Author(s): 寺嶋 廣美、塩山 善之, 他
  • Journal Title: 福岡医学会雑誌 99 Pages: 1-6
  • NAID: 120000985143
• [Journal Article] Reproducibility of the abdominal and chest wall position by voluntary breath-hold technique using a laser-based monitoring and visual feedback system. (2007)
  • Author(s): Nakamura K, Shioyama Y, Nomoto S, Ohga S, Toba T, Yoshitake T, Anai S, Terashima H, Honda H.
  • Journal Title: Int J Radiat Oncol Biol Phys 68 Pages: 267-272
  • Peer Reviewed
• [Journal Article] Preserving functional lung using perfusion imaging and intensity-modulated radiation therapy for advanced-stage non-small cell lung cancer. (2007)
  • Author(s): Shioyama Y, Jang SY, LiuHH, Guerrero T, Wang X, Gayed IW, Erwin WD, Liao Z, Chang JY, Jeter M, Yaremko BP, Borghero YO, Cox JD, Komaki R, Mohan R.
  • Journal Title: Int J Radiat Oncol Biol Phys 68 Pages: 1349-1358
  • Peer Reviewed
• [Journal Article] Reproducibility of the abdominal and chest wall position by voluntary breath-hold technique using a laser-based monitoring and visual feedback system (2007)
  • Author(s): Nakamura K, Shioyama Y, Nomoto S, Ohga S, Toba T, Yoshitake T, Anai S, Terashima H, Honda H
  • Journal Title: Int J Radiat Oncol Biol Phys 68 Pages: 267-272
  • Peer Reviewed
• [Journal Article] Preserving functional lung using perfusion imaging and intensity-modulated radiation therapy for advanced-stage non-small cell lung cancer (2007)
  • Author(s): Shioyama Y, Jang SY, LiuHH, Guerrero T, Wang X, Gayed IW, Erwin WD, Liao Z, Chang JY, Jeter M, Yaremko BP, Borghero YO, Cox JD, Komaki R, Mohan R
  • Journal Title: Int J Radiat Oncol Biol Phys 68 Pages: 1349-1358
  • Peer Reviewed
• [Journal Article] 肺癌放射線治療における代謝画像、機能画像の応用 (2007)
  • Author(s): 塩山 善之
  • Journal Title: 映像情報Medical 39 Pages: 1090-1095
• [Journal Article] Reproducibility of the abdominal and chest wall position by voluntary breath-hold technique using a laser-based monitoring and visual feedback system (2007)
  • Author(s): Nakamura K, Shioyama Y, et. al.
  • Journal Title: Int J Radiat Oncol Biol Phys 68 Pages: 267-272
  • Peer Reviewed
• [Journal Article] A case of radiation fibrosis appearing as mass-like consolidation after SBRT with elevation of serum CEA.
  • Author(s): Terashima K, Shioyama Y, Nomoto S, Ohga S, Nonoshita T, Ohnishi K, Atsumi K, Yabuuchi H, Hirata H, Honda H.
  • Journal Title: Case Report in Medicine (In press)
  • Peer Reviewed
• [Presentation] 肺定位照射後の放射線誘発肋骨骨折の検討. (2010)
  • Author(s): 浅井佳央里, 塩山善之, 大賀才路, 野々下豪, 吉武忠正, 大西かよ子, 寺嶋広太郎, 平田秀紀, 本田浩
  • Organizer: 第21回日本高精度放射線外部照射研究会
• [Presentation] Clinical Results of Stereotactic Body Radiotherapy for Oligometastatic Lung Tumors. (2009)
  • Author(s): Shioyama Y, Nomoto S, Ohga S, Nonoshita T, Ohnishi K, Terashima K, Nakamura K, Hirata H, Honda H.
  • Organizer: Int J Radiat Oncol Biol Phys 75
• [Presentation] Visual Feedback-guided Breath-hold Technique For Radiotherapy Using A Machine Vision System With A Charge-coupled Device Camera And A Head-mounted Display: An Evaluation Of Breath-hold Reproducibility In Clinical Use. (2009)
  • Author(s): Yoshitake T, Shioyama Y, Ohga S, Nonoshita T, Ohnishi K, Terashima K, Asai K, Hirata H, Nakamura K, Honda H.
  • Organizer: Int J Radiat Oncol Biol Phys 75
• [Presentation] Automated Localization Method for a Lung Tumor on EPID Images without Implanted Markers in Stereotactic Body Radiotherapy. (2009)
  • Author(s): Arimura H, Shioyama Y, Nakamura K, Anai S, Nomoto S, Hirata H, Honda H, Toyofuku F, Onizuka Y, Terashima H.
  • Organizer: Int J Radiat Oncol Biol Phys 75
• [Presentation] 転移性肺腫瘍に対する定位照射の治療成 (2009)
  • Author(s): 塩山善之, 中村和正, 大賀才路, 野々下豪, 吉武忠正, 大西かよ子, 寺嶋広太郎, 野元諭, 平田秀紀, 本田浩
  • Organizer: 日本放射線腫瘍学会第22回学術大会
• [Presentation] 転移性肺腫瘍に対する定位放射線治療. (2009)
  • Author(s): 塩山善之, 野元諭, 大賀才路, 野々下豪, 大西かよ子, 渥美和重, 寺嶋広太郎, 平田秀紀, 本田浩
  • Organizer: 第109回日本外科学会定期学術集会ワークショップ
• [Presentation] Clinical Results of Stereotactic Body Radiotherapy for Oligometastatic Lung Tumors (2009)
  • Author(s): 塩山善之, et al.
  • Organizer: 51^<st>.Annual Meeting of American Society for Radiation Oncology(ASTRO)
  • Place of Presentation: Chicago, USA
• [Presentation] 転移性肺腫瘍に対する定位放射線治療 (2009)
  • Author(s): 塩山善之
  • Organizer: 第109回日本外群学会定期学術集会
  • Place of Presentation: 福岡市
• [Presentation] i期非小細胞肺癌に対する定位放射線治療成績. (2008)
  • Author(s): 塩山善之
  • Organizer: 日本放射線腫瘍学会第21回学術大会
  • Place of Presentation: 札幌市
• [Presentation] I期非小細胞肺癌に対する定位放射線治療成績 (2008)
  • Author(s): 塩山善之
  • Organizer: 日本放射線腫瘍学会第21回学術大会
  • Place of Presentation: 札幌市
• [Presentation] 肺がん定位放射線治療後の肺毒性とその生物・物理学的先行指標. (2007)
  • Author(s): 塩山善之
  • Organizer: 第5回九州がん懇話会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-04-21
• [Presentation] 肺がん定位放射線治療後の肺毒性とその生物・物理学的先行指標 (2007)
  • Author(s): 塩山善之
  • Organizer: 第5回九州がん懇話会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-04-21
• [Presentation] Usefulness od serum KL-6 and SP-D levels for predicting radiation pneumonitis after stereotactic radiotherapy for lung tumors. (2007)
  • Author(s): Shioyama Y.
  • Organizer: 49th Annual Meeting of the American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Los Angeles
• [Presentation] I期非小細胞肺癌に対する定位放射線治療:T1, T2における治療成績の比較. (2007)
  • Author(s): 塩山善之
  • Organizer: 第20回日本放射線腫瘍学会学術大会
  • Place of Presentation: 福岡市
• [Presentation] Usefulness od serum KL-6 and SP-D levels for predicting radiation pneumonitis after stereotactic radiotherapy for lung tumors (2007)
  • Author(s): Shioyama Y.
  • Organizer: 49th Annual Meeting of the American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Los Angeles
• [Presentation] I期非小細胞肺癌に対する定位放射線治療 : T1, T2における治療成績の比較 (2007)
  • Author(s): 塩山善之
  • Organizer: 第20回日本放射線腫瘍学会学術大会
  • Place of Presentation: 福岡市
• [Presentation] Usefulness od serum KL-6 and SP-D levels for predicting radiation pneumonitis after stereotactic radiotherapy for lung tumors (2007)
  • Author(s): Shioyama Y, et. al.
  • Organizer: 49^<th>Annual Meeting of the American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Los Angeles, USA
• [Presentation] Case Series Study of 26 Patients Who Developed Fatal Radiation Pneumonitis (RP) after Stereotactic Body Radiotherapy for Lung Cancer.
  • Author(s): Onishi H, Marino K, Terahara A, Kokubo M, Onimaru R, Shioyama Y, Matsuo Y, Kozuka, T Ishikura S, Hiraoka M.
  • Organizer: Int J Radiat Oncol Biol Phys 75
• [Book] 化学放射線療法の適応には年齢や腫瘍の大きさなどに制限があるか (2009)
  • Author(s): 中西洋一編
  • Publisher: 肺がん薬物療法Q&A臨床現場での考え方南江堂
• [Remarks]
  • URL: http://www.radiol.med.kyushu-u.ac.jp/index.html