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Predicting the tumor response to radiotherapy for high-grade gliomas: Clinical significance of hypoxia-related genes

Research Project

Project/Area Number 18591386
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

OGAWA Kazuhiko  University of the Ryukyus, 医学部附属病院, Associate Professor (40253984)

Co-Investigator(Kenkyū-buntansha) YOSHII Yoshihiko  University of the Ryukyus, Faculty of Medicine, Professor (50110507)
KINJO Takao  University of the Ryukyus, Faculty of Medicine, Associate Professor (30284962)
TSUCHIDA Yukihiro  University of the Ryukyus, University Hospital, Assistant Professor (90363663)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,910,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsHigh-grade gliomas / Radiotherapy / tumor response / Hypoxia
Research Abstract

1) Treatment protocol for high-grade gliomas has been established.
2) Influence of tumor cell and stroma sensitivy has been analyzed and both tumor cell and storma sensitivity were found to have influence on tumor response to radiation.
3) Clinical samples of high grade gliomas have been collected according to the protocol.
4) We are now investigating the relation between the hypoxia-related genes and tumor response to radiotherapy for high-grade gliomas.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (13 results)

All 2007 2006

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Influence of tumor cell and stroma sensitivity on tumor response to radiation.2007

    • Author(s)
      Ogawa K, Gerweck LE, et al.
    • Journal Title

      Cancer Research 67

      Pages: 4016-4021

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Predicting the tumor response to radiotherapy using microarray analysis : a review2007

    • Author(s)
      Ogawa K, Murayama S, et al.
    • Journal Title

      Oncology Reports 18

      Pages: 1243-1248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of tumor cell and stroma sensitivity on tumor response to radiation.2007

    • Author(s)
      Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE.
    • Journal Title

      Cancer Research 67

      Pages: 4016-4021

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Predicting the tumor response to radiotherapy using microarray analysis: a review.2007

    • Author(s)
      Ogawa K, Murayama S, Mori M.
    • Journal Title

      Oncology Reports 18

      Pages: 1243-1248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperfractionated radiotherapy and multi-agent chemotherapy (procarbazine, ACNU and vincristine) for high-grade gliomas : a prospective study2006

    • Author(s)
      Ogawa K, Yoshii Y, Tsuchida Y Murayama S, et al.
    • Journal Title

      Anticancer Research 26

      Pages: 2457-2462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phase II trial of radiotherapy after hyperbaric oxygenation with chem otherapy for high-grade gliomas2006

    • Author(s)
      Ogawa K, Yoshii Y, Murayama S, et al.
    • Journal Title

      British Journal of Cancer 95

      Pages: 862-868

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tumor cell radiosensitivity is a major determinant of tumor response to radiation2006

    • Author(s)
      Gerweck LE, Ogawa K, et al.
    • Journal Title

      Cancer Research 66

      Pages: 8352-8355

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hyperfractionated radiotherapy and multi-agent chemotherapy (procarbazine, ACNU and vincristine) for high-grade gliomas: a prospective study.2006

    • Author(s)
      Ogawa K, Yoshii Y, Toita T, Saito A, Kakinohana Y, Iraha S, Sugimoto K, Tsuchida Y, Tamaki W, Adachi G, Hyodo A, Murayama S.
    • Journal Title

      Anticancer Research 26

      Pages: 2457-2462

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas.2006

    • Author(s)
      Ogawa K, Yoshii Y, Inoue O, Toita T, Saito A, Kakinohana Y, Adachi G, Iraha S, Tamaki W, Sugimoto K, Hyodo A, Murayama S.
    • Journal Title

      British Journal of Cancer 95

      Pages: 862-868

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tumor cell radiosensitivity is a major determinant of tumor response to radiation.2006

    • Author(s)
      Gerweck LE, Vijayappa S, Kurimasa A, Ogawa K, Chen DJ
    • Journal Title

      Cancer Research 66

      Pages: 8352-8355

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脳腫瘍治療の最前線悪性グリオーマに対する放射線治療、HBOと化学療法の併用療法第II相試験2007

    • Author(s)
      小川和彦, 吉井與志彦, 土田幸広, 村山貞之, 他
    • Organizer
      第45回日本癌治療学会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腫瘍細胞及び間質の放射線感受陛における放射線治療効果に対する影響2007

    • Author(s)
      小川和彦, 村山貞之, 他
    • Organizer
      第165回日本医学放射線学会九州地方会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 悪性グリオーマに対する放射線照射とHBOの併用療法2006

    • Author(s)
      小川和彦, 吉井與志彦, 土田幸広, 村山貞之, 他
    • Organizer
      第41回日本高気圧環境・潜水医学会
    • Place of Presentation
      沖縄
    • Year and Date
      2006-10-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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