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Study on twnor growth inhibition by small interference RNAin nude mice

Research Project

Project/Area Number 18591389
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNara Medical University

Principal Investigator

OHNISHI Ken  Nara Medical University, School of Medicine, Department of Biology, Associate Professor (50152195)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordsradiation / apoptosis / cell death signal transduction / cell survival signal transduction / DNA-repair / cell survival / sensitization / RNA干渉 / siRNA / 担がんマウス / 腫瘍増殖抑制
Research Abstract

Interference with anti-apoptosis and/or cellular proliferation signal transduction is regarded to result in effective radiation cancer therapy. This study examined the effectiveness of siRNA targeting key factors (NBS1 and XIAP) in DNA repair and signal transduction for anti-apoptosis and/or cellular proliferation after radiation using cultured human cancer cells and tumor-transplanted nude mica Radiation sensitivity and apoptosis were analyzed with colony formation assay, Western blot, fluorescent immuno-cytochemistry and hoechst staining using wild-type p53 or mutated p53 gene-transfected human lung and tongue cancer cells. Further the cancer cells were transfected with plasmids which were inserted with NBS1-siRNA expressing DNA cassette and radiation, sensitivity of the plasmid-transfected cells was examined. siRNAs targeting NBS1 and XIAP enhanced radiation sensitivity p53 independently and even more pronounced in mutated p53 cells compared with wild-type p53 cells. Enhanced radiation sensitivity was not observed in several clones from NBS1-siRNA expressing plasmid-transfected cells at this time. Our results suggest that t NBS1-siRNA and XIAP siRNA might contribute to high curative efficiency in radiation cancer therapy for malignant cancer leading to enhanced p53 independent radiation sensitivity. In addition, it was suggested that further experiments are required for study on the effectiveness of siRNAs in vivo system.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (133 results)

All 2008 2007 2006 Other

All Journal Article (38 results) (of which Peer Reviewed: 14 results) Presentation (89 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Development of thermotolerance requires interaction between polymerase β and heat shock proteins2008

    • Author(s)
      Takahashi A, et. al.
    • Journal Title

      Cancer Science 99

      Pages: 973-978

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation2008

    • Author(s)
      Yamakawa N, et. al.
    • Journal Title

      Cancer Science (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA tareetina XIAP2008

    • Author(s)
      Ohnishi K, et. al.
    • Journal Title

      Oncology Reports (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Time course and spacial distribution of UV effects on human skin in organ culture2008

    • Author(s)
      Mori E, et. al.
    • Journal Title

      Journal of Radiation Research (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] p53 targeting can enhance cancer therapy via radiation,heat and anti-cancer agents2008

    • Author(s)
      Ohnishi T, et. al.
    • Journal Title

      Anticancer Agents Med Chem (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of thermotolerance requires interaction between polymerase β and heat shock proteins2008

    • Author(s)
      Takahashi, A., et. al.
    • Journal Title

      Cancer Science 99

      Pages: 973-978

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Time course and spacial distribution of UV effects on human skin in organ culture2008

    • Author(s)
      Mori, E., et. al.
    • Journal Title

      Journal of Radiation Research 49

      Pages: 269-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation2008

    • Author(s)
      Yamakawa, N., et. al.
    • Journal Title

      Cancer Science (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targetingXIAP2008

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      Oncology Reports (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] p53 targeting can enhance cancer therapy via radiation, heat and anti-cancer agents2008

    • Author(s)
      Ohnishi, T., et. al.
    • Journal Title

      Anticancer Agents in Medicinal Chemistry (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP.2008

    • Author(s)
      Ohnishi K, et. al.
    • Journal Title

      Oncol Rep. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation.2008

    • Author(s)
      Yamakawa N, et. al.
    • Journal Title

      Cancer Sci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of thermotolerance requires interaction between polymerase β and heat shock proteins.2008

    • Author(s)
      Takahashi A, et. al.
    • Journal Title

      Cancer Sci. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time course and spacial distribution of UV effects on human skin in organ culture.2008

    • Author(s)
      Mori E, et. al.
    • Journal Title

      J Radiat Res. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 targeting can enhance cancer therapy via radiation, heat and anti-cancer agents.2008

    • Author(s)
      Ohnishi T, et. al.
    • Journal Title

      Anticancer Agents Med Chem. (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population2007

    • Author(s)
      Masunaga S, et. al.
    • Journal Title

      Oncology Reports 18

      Pages: 1589-1596

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hyperthermic sensitizers targeting heat-induced signal transductions2007

    • Author(s)
      Ohnishi K, et. al.
    • Journal Title

      Annals Cancer Research Therapy 15

      Pages: 35-40

    • NAID

      130000119679

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperthermic sensitizers targeting heat-induced signal transductions2007

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      Annals Cancer Research Therapy 15

      Pages: 35-40

    • NAID

      130000119679

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population2007

    • Author(s)
      Masunaga, S., et. al.
    • Journal Title

      Oncology Reports 18

      Pages: 1589-1596

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population.2007

    • Author(s)
      Masunaga S, et. al.
    • Journal Title

      Oncol Rep. 18

      Pages: 1589-1596

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperthermic sensitizers targeting heat-induced signal transductions.2007

    • Author(s)
      Ohinishi K, et. al.
    • Journal Title

      Ann Cancer Res Ther. 15

      Pages: 35-40

    • Related Report
      2007 Annual Research Report
  • [Journal Article] LY294002,an inhibitor of PI-3K,enhances heat sensitivity independently of p53 status in human lung cancer cells2006

    • Author(s)
      Ohnishi K., et. al.
    • Journal Title

      International Journal of Oncology 29

      Pages: 249-253

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heat-induced phosphorylation of NBS1 in human skin fibroblast cells2006

    • Author(s)
      Ohnishi K., et. al.
    • Journal Title

      Journal of Cellular Biochemistry 99

      Pages: 1642-1650

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] siRNA targeting NBSI or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status2006

    • Author(s)
      Ohnishi K., et. al.
    • Journal Title

      Radiation Research 166

      Pages: 454-462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Induction of radiation resistance by a heat shock protein inhibitor,KNK437,in human glioblastoma cells2006

    • Author(s)
      Ohnishi K., et. al.
    • Journal Title

      International Journal of Radiation Biology 82

      Pages: 569-575

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DNA修復関連遺伝子を標的としたRNA干渉によるがん細胞の放射線増感2006

    • Author(s)
      大西 健, et. al.
    • Journal Title

      癌の臨床 52

      Pages: 41-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 変異型p53タンパク質に正常機能を回復させるシャペロン分子2006

    • Author(s)
      大西 健, et. al.
    • Journal Title

      放射線生物研究 41

      Pages: 99-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] LY294002, an inhibitor of PI-3K, enhances heat sensitivity indepenendently of P53 status in human lung cancer cells2006

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      International Journal of Oncology 29

      Pages: 249-253

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Heat-induced phospkorylation of NBS1 in human skin cells2006

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      Journal of Cellular Biochemistry 99

      Pages: 1642-1650

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells2006

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      Intemational Journal of Radiation Biology 82

      Pages: 569-575

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DNA修復関連遺伝子を標的としたRNA干渉によるがん細胞の放射線増感2006

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      癌の臨床 52

      Pages: 41-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 変異型p53タンパク質に正常機能を回復させるシャペロン分子2006

    • Author(s)
      Ohnishi, K., et. al.
    • Journal Title

      放射線生物研究 41

      Pages: 99-108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] LY294002, an inhubitor of PI-3K, enhances heat sensitivity independently of p53 atatus in human lung cancer cells.2006

    • Author(s)
      Ohnishi K. et al.
    • Journal Title

      Int. J. Oncol. 29巻

      Pages: 249-253

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heat-induced phosphorylation of NBS1 in human skin fibroblast cells.2006

    • Author(s)
      Onishi K. et al.
    • Journal Title

      J. Cell. Biochem. 99巻

      Pages: 1642-1650

    • Related Report
      2006 Annual Research Report
  • [Journal Article] siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status.2006

    • Author(s)
      Onishi K. et al.
    • Journal Title

      Radiat. Res. 166巻

      Pages: 454-462

    • Related Report
      2006 Annual Research Report
  • [Journal Article] LY294002, an inhibit of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells.2006

    • Author(s)
      Onishi K. et al.
    • Journal Title

      Int. J. Radiat. Biol. 82巻

      Pages: 569-575

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DNA修復関連遺伝子を標的としたRNA干渉によるがん細胞の放射線増感2006

    • Author(s)
      大西健ら
    • Journal Title

      癌の臨床 52巻

      Pages: 41-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 変異型p53タンパク質に正常機能を回復させるシャペロン分子2006

    • Author(s)
      大西健ら
    • Journal Title

      放射線生物研究 41巻

      Pages: 99-108

    • Related Report
      2006 Annual Research Report
  • [Presentation] Cancer Stem Cellの研究の最近の動向2008

    • Author(s)
      近藤 夏子, et. al.
    • Organizer
      第10回癌治療増感研究会シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2008-02-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cancer Stem Cellの研究の最近の動向2008

    • Author(s)
      Kondo, N., et. al.
    • Organizer
      10th Symposium on Sensitization of Cancer Treatment in Nara
    • Place of Presentation
      Nara
    • Year and Date
      2008-02-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cancer Stem Cellの研究の最近の動向2008

    • Author(s)
      近藤 夏子, et. al.
    • Organizer
      第10回癌治療増感研究会シンポジウム
    • Place of Presentation
      奈良市ならまちセンター,奈良
    • Year and Date
      2008-02-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Heat sensitization by PD98059,an inhibitor targeting for MAPK cascade2007

    • Author(s)
      Nagata Y, et. al.
    • Organizer
      12nd Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Queensland,Australian
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heat sensitization by PD98059, an mtunnor targeting for MAPK cascade2007

    • Author(s)
      Nagata, Y., et. al.
    • Organizer
      12th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Queensland, Australia
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heat sensitization by PD98059,an inhibitor targeting for MAPK cascade.2007

    • Author(s)
      Nagata Y, et. al.
    • Organizer
      12nd Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Queensland,Australian
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱によるDNA二重鎖切断生成2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第50回日本放射線影響学会
    • Place of Presentation
      千葉
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heat-induced DNA double strand break formation2007

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      The 50th Annual Meeting of the Japanese Radiation Research Society
    • Place of Presentation
      Chiba
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱によるDNA二重鎖切断生成.2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第50回日本放射線影響学会
    • Place of Presentation
      幕張メッセ,千葉
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] XIAP標的siRNAによって誘導される変異型p53がん細胞の放射線増感とp53タンパク質の転写活性異常との関係2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第50回日本放射線影響学会
    • Place of Presentation
      千葉
    • Year and Date
      2007-11-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relation between radiation sensitization and dysfunction of p53 as a transcription factor in mutated p53 cancer cells by siRNA targeting XIAP2007

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      The 50th Annual Meeting of the Japanese Radiation Research Society
    • Place of Presentation
      Chiba
    • Year and Date
      2007-11-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAP標的siRNA によって誘導される変異型p53がん細胞の放射線増感とp53タンパク質の転写活性異常との関係.2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第50回日本放射線影響学会
    • Place of Presentation
      幕張メッセ,千葉
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱感受性と温熱耐性を決定する標的遺伝子の探索2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 変異型p53に優位なXIAP標的siRNAによる放射誘発アポトーシスの増強2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] p53変異型口腔扁平上皮癌細胞に対するBNCTの効果に関する検討2007

    • Author(s)
      藤田 祐生, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The study of target genes deciding heat-sensitivity and the thermotolerance2007

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mutated p53-dominant enhancement of radiation-induced apoptosis by XIAP-siRNA2007

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of BNCT on the oral squamous cell carcinoma cells with p53 gene mutation2007

    • Author(s)
      Fujita, Y., et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱感受性と温熱耐性を決定する標的遺伝子の探索.2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 変異型p53に優位なXIAP的siRNAによる放射線誘発アポトーシスの増強.2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] p53変異型口腔扁平上皮癌細胞に対するBNCTの効果に関する検討.2007

    • Author(s)
      藤田 祐生, et. al.
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNA損傷認識および修復機構を中心としたがん温熱療法における標的遺伝子の探索2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第24回日本ハイパーサーミア学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Tween80と温熱併用処理によるがん細胞増殖停止へのNBS1の関与2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第24回日本ハイパーサーミア学会
    • Place of Presentation
      前橋
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The study of target genes in hyperthermia mainly on recognition and repair of DNA damage2007

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      The 24th Annual Meeting of The Japanese Society of Hyperthermic Oncology
    • Place of Presentation
      Maebashi
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of NBS1 to cancer cell growth arrest by combined treatment of Tween80 and heat2007

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      The 24th Annual Meeting of The Japanese Society of Hyperthermic Oncology
    • Place of Presentation
      Maebashi
    • Year and Date
      2007-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA損傷認識および修復機構を中心としたがん温熱療法における標的遺伝子の探索.2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第24回日本ハイパーサーミア学会
    • Place of Presentation
      前橋テルサ,群馬
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Tween 80と温熱併用処理によるがん細胞増殖停止へのNBS1の関与.2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第24回日本ハイパーサーミア学会
    • Place of Presentation
      前橋テルサ,群馬
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 各種細胞における温熱によるγH2AX誘導2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第37回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      筑波
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAP標的siRNAによって変異型p53がん細胞で効率的に増強される放射線誘導アポトーシス2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第37回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      筑波
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 各種細胞における温熱によるγH2AX誘導2007

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      第37回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      Tsukubac
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAP標的siRNAによって変異型p53がん細胞で効率的に増強される放射線誘導アポトーシス2007

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      第37向日本医学放射線学会生物部会学術大会
    • Place of Presentation
      Tsukuba
    • Year and Date
      2007-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 各種細胞における温熱によるγH2AX誘導.2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第37回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      つくば国際会議場,筑波
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] XIAP標的siRINAによって変異型p53がん細胞で効率的に増強される放射線誘導アポトーシス.2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第37回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      つくば国際会議揚,筑波
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gene expression of p53-regulated genes in mammalian cultured cells after exposure to space enviromnent2007

    • Author(s)
      Ohnishi T, et. al.
    • Organizer
      18th Annual NASA Space Radiation Investigators' Workshop
    • Place of Presentation
      Sonoma,USA
    • Year and Date
      2007-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gene expression of P53-regulated genes in mammalian cultured cell after exposure to space environment.2007

    • Author(s)
      Ohnishi T, et. al.
    • Organizer
      18th Annual NASA Space Radiation in Investigators'Workshop
    • Place of Presentation
      Sonoma,USA
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Radiation-induced adaptive response and genomic instability2007

    • Author(s)
      Ohnishi T, et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spatio-temporal responses to different UV wavelengths in human skin organ culture2007

    • Author(s)
      Mori E, et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spatio-temporal responses to different UV wavelengths in human skin organ culture2007

    • Author(s)
      Mori, E., et. al.
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Radiation-induced adaptive response and genomic instability.2007

    • Author(s)
      Ohnishi T, et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Spatio-temporal responses to different UV wavelengths in humanskin organ culture.2007

    • Author(s)
      Mori E, et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a p53-independent manner2007

    • Author(s)
      Ohnishi K., et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] High-LET radiations enhanced apoptosis regardless of p53 status2007

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] p53-independent apoptosis on human gingival cancer cells by heavy-ion beams2007

    • Author(s)
      Yamakawa, N., et. al.
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a p53-independent manner2007

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-07-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a P53-independent manner2007

    • Author(s)
      Ohnishi K., et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] p53-independent apoptosis on human gingival cancer cells by heavy-ion beams2007

    • Author(s)
      Yamakawa N, et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] P53-independent apoptosis on human gingival cancer cells by heavy-ion beams.2007

    • Author(s)
      Yamakawa N, et. al.
    • Organizer
      13rd International Congress of Radiation Research
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-07-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱感受性を増感する標的遺伝子の探索2007

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第13回癌治療増感研究会
    • Place of Presentation
      前橋
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 界面活性剤Tween80と温熱の併用による細胞増殖停止のメカニズム2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第13回癌治療増感研究会
    • Place of Presentation
      前橋
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱感受性を増感する標的遺伝子の探索2007

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      13th Annual Meeting on the Sensitization of Cancer Treatment
    • Place of Presentation
      Maebashi
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 界面活性剤Tween80と温熱の併用による細胞増殖停止のメカニズム2007

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      13th Annual Meeting on the Sensitization of Cancer Treatment
    • Place of Presentation
      Maebashi
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱感受性を増感する標的遺伝子の探索.2007

    • Author(s)
      高橋 昭久, et.al.
    • Organizer
      第13回癌治療増感研究会
    • Place of Presentation
      前橋テルサ,群馬
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 界面活性剤Tween80と温熱の併用による細胞増殖停止のメカニズム.2007

    • Author(s)
      大西 健, et. al.
    • Organizer
      第13回癌治療増感研究会
    • Place of Presentation
      前橋テルサ,群馬
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温熱耐性におけるpolβとHSPの役割2006

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of polymerase beta and heat shock protein on the heat tolerance2006

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      65th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAP標的siRNAによるヒト非小細胞肺がん細胞の放射線増感2006

    • Author(s)
      大西 健, et. al.
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト歯肉扁平上皮癌細胞における重粒子線の殺細胞効果およびアポトーシス誘導2006

    • Author(s)
      山川 延宏, et. al.
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Radiation sensitization by siRNA-targeted for XIAP in human lung cancer cells2006

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      65th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cellular sensitivity and apoptosis on human gingival cancer cells by heavy-ion beams2006

    • Author(s)
      Yamakawa, N., et. al.
    • Organizer
      65th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dynamics of DNA damage-recognizing proteins at heat・induced foci2006

    • Author(s)
      Takahashi A., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of polymerase β and HSPs on the thermo・tolerance2006

    • Author(s)
      Yamakawa N., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Apoptosis・related protein expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53 with protein microarray2006

    • Author(s)
      Kajiwara A., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heat sensitization by targeting heat-induced cell survival signaling tran sduction through Akt2006

    • Author(s)
      Ohnishi K., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heat sensitization by PD98059, an inhibitor targeted for MAPK cascade2006

    • Author(s)
      Nagata Y., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dynamics of DNA damage-recognizing proteins at heat-induced foci2006

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of polymerase β and HSPs on the thermo-tolerance2006

    • Author(s)
      Yamakawa, N., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Apoptosis-related protein expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53 with protein microarray2006

    • Author(s)
      Kajiwara, A., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Heat sensitization by targeting heat-induced cell survival signaling transduction through Akt2006

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      The 4th Asian Congress of Hyperthermic Oncology
    • Place of Presentation
      Nara
    • Year and Date
      2006-09-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAPを標的としたsiRNAによるヒト肺がん細胞の放射線増感2006

    • Author(s)
      大西 健, et. al.
    • Organizer
      第49回日本放射線影響学会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Radiation sensitization by siRNA targeting XIAP in human lung cancer cells2006

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      The 49th Annual Meeting of the Japanese Radiation Research Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of 5-Azacytidine on radiation cell killing and p532006

    • Author(s)
      Tsuji, K., et. al.
    • Organizer
      The 49th Annual Meeting of the Japanese Radiation Research Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-09-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 重粒子線誘導トラックにおけるDNA損傷認誌タンパク質の挙動2006

    • Author(s)
      大西 健, et. al.
    • Organizer
      第49回日本放射線影響学会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dynamics of DNA damage-recognizing proteins at HZE particles-induced track2006

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      The 49th Annual Meeting of the Japanese Radiation Research Society
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 界面活性剤Tween80併用で増強される温熱による腫瘍増殖抑制2006

    • Author(s)
      大西 健, et. al.
    • Organizer
      第45回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      弘前
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱によるDNA損傷認識タンパク質の挙動2006

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第45回日本医学放射線学会生糠会学術大会
    • Place of Presentation
      弘前
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 界面活性剤Tween80併用で増強される温熱による腫瘍増殖抑制2006

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      第43回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      Hkosaki
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱によるDNA損傷認識タンパク質の挙動2006

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      第45回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      Hirosaki
    • Year and Date
      2006-07-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱による細胞死の要因について2006

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第8回関西ハイパーサーミア研究会・第15回高温度療法臨床研究会合同研究会
    • Place of Presentation
      大阪
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱耐性獲得機構について2006

    • Author(s)
      山川 延宏, et. al.
    • Organizer
      第8回関西ハイパーサーミア研究会・第15回高温度療法臨床研究会合同研究会
    • Place of Presentation
      大阪
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 界面活性剤Tween80と温熱を併用した腫瘍増殖抑制効果2006

    • Author(s)
      大西 健, et. al.
    • Organizer
      第8回関西ハイパーサーミア研究会・第15回高温度療法臨床研究会合同研究会
    • Place of Presentation
      大阪
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱による細胞死の要因について2006

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      第8回関西ハイパーサーミア研究会・第15回高温度療法臨床研究会合同研究会
    • Place of Presentation
      Osaka
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱耐性獲得機構にっいて2006

    • Author(s)
      Yamakawa, N., et. al.
    • Organizer
      第8回関西ハイパーサーミア研究会・第15回高温度療法臨床研究会合同研究会
    • Place of Presentation
      Osaka
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 界面活性剤Tween80と温熱を併用した腫瘍増殖抑制効果2006

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      第8回関西ハイパーサーミア研究会・第15回高温度療法臨床研究会合同研究会
    • Place of Presentation
      Osaka
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] グリセロールによる抗癌剤増感効果機構2006

    • Author(s)
      澤西 和恵, et. al.
    • Organizer
      第12回癌治療増感研究会
    • Place of Presentation
      富山
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱耐性とDNA二本鎖切断との関係2006

    • Author(s)
      高橋 昭久, et. al.
    • Organizer
      第12回癌治療増感研究会
    • Place of Presentation
      富山
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] グリセロールによる抗癌剤増感効果機構2006

    • Author(s)
      Swanishi, K., et. al.
    • Organizer
      12th Annual Meeting on the Sensitization of Cancer Treatment
    • Place of Presentation
      Toyama
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温熱耐性とDNA二本鎖切断との関係2006

    • Author(s)
      Takahashi, A., et. al.
    • Organizer
      12th Annual Meeting on the Sensitization of Cancer Treatment
    • Place of Presentation
      Toyama
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAP標的siRNAによる放射線増感2006

    • Author(s)
      大西 健, et. al.
    • Organizer
      第8回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2006-02-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] XIAP標的siRNAによる放射線増感2006

    • Author(s)
      Ohnishi, K., et. al.
    • Organizer
      8th Symposium on Sensitization of Cancer Treatment in Nara
    • Place of Presentation
      Nara
    • Year and Date
      2006-02-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] ハイパーサーミア-がん温熱療法ガイドブック-(分担執筆:温熱による情報伝達の変化)2008

    • Author(s)
      大西 健
    • Publisher
      毎日健康サロン出版(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 温熱免疫療法2008

    • Author(s)
      大西 健
    • Publisher
      診断と治療社(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] ハイパーザーミア-がん温熱療法ガイドブック-(分担執筆:温熱による情報伝達の変化)2008

    • Author(s)
      大西 健
    • Publisher
      毎日健康サロン出版(印刷中)
    • Related Report
      2007 Annual Research Report
  • [Book] ハイパーサーミア-がん温熱療法ガイドブック-(分筆標題 : 温熱による情報伝達の変化)

    • Author(s)
      Ohnishi, K
    • Publisher
      毎日健康サロン出版
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 温熱免疫療法(分筆標題 : 細胞内の情報伝達に対する温熱の影響)

    • Author(s)
      Ohnishi T, et. al.
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.naramed-u.ac.jp/~biol/

    • Related Report
      2007 Final Research Report Summary

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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