Research for irradiation reproducibility of interstitial brachytherapy using in vivo dosietry
| Project/Area Number |
18591397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
NOSE Takayuki Japanese Foundation For Cancer Research, 癌研究所物理部, 研究員 (10283748)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Akira 財団法人癌研究会, 癌研究所物理部, 研究員 (70012771)
KOZUKA Takuyo 財団法人癌研究会, 癌研究所物理部, 研究員 (30300932)
SUMIDA Iori 財団法人癌研究会, 癌研究所物理部, 研究員 (10425431)
TAKAHASHI Yutaka 財団法人癌研究会, 財団法人癌研究会, 研究員 (40353461)
YAMASHITA Takashi 財団法人癌研究会, 財団法人癌研究会, 研究員 (70110939)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | 放射線治療学 / In vivo dosimetry / 組織内照射 / 照射精度 / 小線源治療 / In vivo線量実測 / ミニチュアTLD / ガラス線量計 |
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| Research Abstract |
高精度のガラス線量計およびミニチュアTLD線量計を基準照射により選択した。モンテカルロ計算によるTr-192線源の再現を行った。骨盤部組織内照射66人生004か所のガラス線量計による測定の結果、計算装置の計算値に対して9節+-2節であり、直腸壁では99%+-20凱尿道では96%+-26%、ターゲットでは91‰+-節、外燈皮膚では125%+-32%という結果を得た。これらから、直腸、尿道というリスク臓器は、ターゲットやアプリケータと独立した勤きが原国で約20%のばらつきが生じることを明らかにした。ターゲットの計算線量はばらつきが8%と少ないものの、一節というずれは市販計画装置に不均質補正が組み込まれていないことが原因であることを明らかにした。これらは国際詰、国際学会で発表した。乳房組織内照射での再発匪検証への応用を全国規模で施行するため、他施設共同臨床試験のプロトコールを本年2月光威し、4施設(埼玉医科大学、川崎医科大学、大阪医療センター、会津中央病院)の参加を得て実施中である。
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Preliminary result of accelerated partial breast irradiation after breast-conserving surgery2009
Author(s)
Yoshida K, Nose T, Masuda N, Yamazaki H, Kotsuma T, Yoshida M, Yamamura J, Masuda H, Shin E, Nakaba H, Komoike Y, Tokuda Y, Takeda M, Kuriyama K
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Journal Title
Breast Cancer 16
Pages: 105-112
NAID
Related Report
Peer Reviewed
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[Journal Article] In vivo dosimetry of high-dose-rate interstitial brachytherapy in the pelvic region : use of a radiophotoluminescence glass dosileter for measurement of 1004 points in 66 patients with pelvic malignancy.2008
Author(s)
Nose T, Koizulli M, Yoshida K, Nishiyama K,Sasaki J, 0hnishi T, Kozuka T, Gomi K,0guchi M, Sumida l, Takahashi Y,Ito A, Yamashiya T
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Journal Title
Int J Radiat oncol Biol Phys 70(2)
Pages: 626-633
Related Report
Peer Reviewed
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[Journal Article] In vivo dosimetry of high-dose-rate interstitial brachytherapy in the pelvic region : use of a radiophotoluminescence glass dosimeter for measurement of 1004 points in 66 patients with pelvic malignancy2008
Author(s)
Nose T, Koizumi M, Yoshida K, Nishiyama K, Sasaki J, Ohnishi T, Kozuka T, Gomi K, Oguchi M, Sumida I, Takahashi Y, Ito A, Yamashita T
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Journal Title
Int J Radiat Oncol Biol Phys 70(2)
Pages: 626-633
Related Report
Peer Reviewed
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[Journal Article] Preliminary result of accelerated partial breast irradiation after breast-conserving surgery2008
Author(s)
Yoshida K, Nose T, Masuda N, Yamazaki H, Kotsuma T, Yoshida M, Yamamura J, Masuda H, Shin E, Nakaba H, Komoike Y, Tokuda Y, Takeda M, Kuriyama K.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] In vivo dosimetry of high-dose-rate interstitial brachytherapy in the pelvic region:use of a radiophotoluminescence glass dosimeter for measurement of 1004 points in 66 patients with pelvic malignancy2008
Author(s)
Nose T, Koizumi M, Yoshida K, Nishiyama K, Sasaki J, Ohnishi T, Kozuka T, Gomi K, Oguchi M. Sumida I, Takahashi Y, Ito A, Yamashita T
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Journal Title
Int J Radiat Oncol Biol Phys 70(2)
Pages: 626-633
Related Report
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[Journal Article] A pilot study of wider indication for accelerated partial breast rradiation : lntraop re-excision combined with high-dose-rate interstitial brachytherapy2006
Author(s)
Nose T,Komoike Y,Yoshida K,Koizumi, M,Motomura K,Kasugai T,Inaji H,Nishiyama K,Koyama H,Kozuka T,Gomi, K,0guchi M,Takahashi Y,Sumida I, Yamashita T
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Journal Title
Breast Cancer 13(3)
Pages: 289-299
Related Report
Peer Reviewed
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[Journal Article] New ambulatory implant technique of high-dose-rate interstitial brachytherapy for prostate cancer2006
Author(s)
Yoshida K, Nose T, Shiomi H, Yoshioka Y, Fujita Y, Kuroda S, Yoshio M, Takahashi T, Kitamura M, Akai H, 0ka T, Hosoki T
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Journal Title
Radiation Medicine 24
Pages: 595-599
NAID
Related Report
Peer Reviewed
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[Journal Article] A pilot study of widwe use of accelerated partial breast irradiation : intraoperative margin-directed re-excicion combined with sole high-dose-rate interstitial brachytherapy.2006
Author(s)
Nose T, Komoike Y, Toshida K, Koizumi M, Motomura K, Kasugai T, Inaji H, Nishiyama K, Koyama H, Kozuka T, Gomi K, Oguchi M, Takahashi Y, Sumida I, Yamashita T
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Journal Title
Breast Cancer 13(3)
Pages: 289-299
Related Report
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[Journal Article] In vivo dosimetry of high-dose-rate interstitial brachytherapy for pelvic region. Study on 66 pelvic malignancy patients measuring 1004 points using radiophotoluminescence glass dosimeters.
Author(s)
Takayuki Nose, Masahiko Koizumi, Ken Yoshida, Kinji Nishiyama, Junichi Sasaki, Takeshi Ohnishi, Takuyo Kozuka, Kotaro Gomi, Masahiko Oguchi, Iori Sumida, Yutaka Takahashi, Akira Ito, Takashi Yamashita
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Journal Title
Int J Radiat Oncol Biol Phys (in submission) (in press)
Related Report
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[Presentation] Optimal use of advanced radiotherapy in multimodanty oncology2007
Author(s)
Nose T, Koizumi M, Yoshida K, Sasaki J, 0nishi T, Nishiyama K, Kozuka T, 0guchi M,Takahashi Y, Sumida l, Yamashita T
Place of Presentation
Rome/ltaly
Year and Date
2007-06-22
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