Research Project
Grant-in-Aid for Scientific Research (C)
In this research, we established firm techniques of tetramer staining and ELTSPOT assay, which could monitor the survivin-2B peptide specific immunological responses. We made out that the vaccination using the surviving-2B peptide with IFA and IFN-a could efficiently induce the peptide specific immunological responses. However, the vaccination could not effectively induce the clinical responses, which have cytoreductive effects in most cases. In many cases which could not be induced the clinical responses, the MHC class I expression level was down-regulated in the primary focus. So, we concluded that the down-regulation of MHC class I expression level might be one of the reasons that the vaccination could not efficiently induce the clinical responses in despite of the induction of the peptide specific Ms. In addition, we investigated the relationship between the MHC class I expression level and the prognosis in cases that were operated in our hospitals. The survival rate of the cases that have the down-regulation of the MHC class I expression level was lower in comparison with the cases that do not have the down-regulation. So the MHC class I expression level might be the novel indication of malignant potential. In this research, we concluded that the most suitable indication of the peptide vaccine therapy might be low-grade cases that the MHC class I expression level was not down-regulated.
All 2008 2007 2006
All Journal Article (29 results) (of which Peer Reviewed: 9 results) Presentation (51 results)
G I Research 16
Pages: 3-9
Microbiol Immunol 52
Pages: 94-106
10025691276
J Transl Med 10
Pages: 24-24
GI Research 16
G. I. Research 16
外科治療(増刊) 96
Pages: 378-382
消化器外科 30
Pages: 1823-1836
J Urol 177
Pages: 1269-1272
J Orol 178
Pages: 692-696
J Immunol 179
Pages: 1803-1813
Surgical Thertapy 96
40015424804
Gastroenterological Surgery 30
J Orpl 178
Surgery Frontier 13
Pages: 231-233
Pages: 239-244
Surgery Frontier 13.3
