Highly sensitive detection of sentinel lymph node by fluorescence tomography based on acousto-optic modulation imaging

• Project/Area Number: 18591427
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: AMARI Masakazu Tohoku University, 大学院・医学系研究科, 助教 (50400312)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808) ; OHUCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710) ; 小林 正樹 東北工業大学, 工学部, 教授 (90332981) ; 小林 芳男 茨城大学, 工学部, 教授 (40250849)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 乳腺外科学 / センチネルリンパ節生検 / 蛍光計測 / がん

Research Abstract

超音波蛍光変調検出法の実用化を目的として、模擬生体における有用性の評価並びに装置の最適化を進めた。模擬生体、食肉を用いた検討である程度の深度にある蛍光色素の検出に成功し、我々が開発した蛍光断層画像計測装置を生体に応用すべく素子をリニアアレイ化したプロ-ブを用い、模擬生体の20-30mmの深さにある蛍光色素を検出することに成功した。この結果から、生体においても従来の検出法を上回る深度の蛍光色素を検出できる可能性が強く示唆された。リニアアレイ型トランスデュ-サの各素子への信号の位相制御による集束化および走査の検討を行い液体散乱媒質中に蛍光体検出にも成功した。以上により装置開発における新たな課題が出てきたが、本研究は実用化に向けて着実に前進した。

Research Products

• [Journal Article] In vivo single molecular imaging and sentinel node navigation by nano-technology for molecular targeting drug delivery system and tailor made medicine (2008)
  • Author(s): Takeda M
  • Journal Title: Breast cancer 15 Pages: 145-152
  • NAID: 10025371809
  • Peer Reviewed
• [Journal Article] Siginificance of irradiation in breast conserving treatment : comparison of local recurrence rates in irradiated and nonirradiated groups (2008)
  • Author(s): Ishida T, Takeda M, Amari M, Ohuchi N
  • Journal Title: Int J Clin Oncol 13 Pages: 12-17
  • Peer Reviewed
• [Journal Article] In vivo single molecular imaging and sentinel node navigation by nano-technology for molecular targeting drug delivery systemand tailor made medicine. (2008)
  • Author(s): Takeda M
  • Journal Title: Breast cancer (In Press)
  • Peer Reviewed
• [Journal Article] Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea. (2007)
  • Author(s): Kobayashi M
  • Journal Title: J. Exp. Botany 58/3 Pages: 465-472
  • Peer Reviewed
• [Journal Article] Fluorescence Tomography of Biological Tissue Based on Ultrasound Tagging Technique. (2007)
  • Author(s): Kobayashi M
  • Journal Title: Proc. SPIE
  • Peer Reviewed
• [Journal Article] Fluorescence tomography in turbid media based on acousto-optic modulation imaging (2006)
  • Author(s): Kobayashi M, Mizumoto T, Shibuya Y, Takeda M and Enomoto M
  • Journal Title: Applied Physics Letter 89 Pages: 1811022-1811022
  • Peer Reviewed
• [Journal Article] Fluorescence tomography in turbid media based on acousto-optic modulation imaging. (2006)
  • Author(s): Kobayashi M
  • Journal Title: Applied Physics Letter 89 Pages: 1811022-1811022
• [Presentation] Nanosized Silver-Iodide Beads as Novel X-ray Contrast Media for Cancer Detection. Breast Cancer, 15, Supplement 1, 37-37, 2008 (2008)
  • Author(s): Takeda M, Sakurai Y, Kobayashi Y, Cong L, Hikage M, Amari M, Ishida T, Gonda K, Ohuchi N
  • Organizer: The 26^<th> Congress of the International Association for Breast Cancer Research, September
  • Place of Presentation: Japan
• [Presentation] Interstitial Nano-particle Tracking and Analysis of the Movements in the Human Tumor Xenografts in Mice. Breast Cancer, 15, Supplement 1, 33-33, 2008 (2008)
  • Author(s): Kawai M, Takeda M, Ishida T, Suzuki A, Amari M, Ohuchi N
  • Organizer: The 26^<th> Congress of the International Association for Breast Cancer Research, September
  • Place of Presentation: Kurashiki, Japan
• [Presentation] Nanosized Silver-Iodide Beads as Novel X-ray Contrast Media for Cancer Detection (2008)
  • Author(s): Takeda M
  • Organizer: The 26^<th> Congress of the International Association for Breast Cancer Research
  • Place of Presentation: 倉敷市
• [Book] 機能性ナノ粒子による生体イメージング-がん診療への応用-。ナノメディシン ナノテクの医療応用(宇理須恒雄) (2008)
  • Author(s): 武田元博、小林芳男、小林正樹、櫻井遊、甘利正和、石田孝宣、鈴木昭彦、大内憲明
  • Publisher: オーム社
• [Book] ナノメディシンナノテクの医療応用(宇理須恒雄編) (2008)
  • Author(s): 武田元博
  • Publisher: オーム社
• [Book] ナノメディシン ナノテクノ医療応用(宇理須恒雄 編) (2008)
  • Author(s): 武田元博、石田孝宣、大内憲明、宇理須恒雄、他
  • Publisher: 機能性ナノ粒子による生体イメージング-がん診療への応用-