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Development of the new treatment that targeted mammary cancer stem cell

Research Project

Project/Area Number 18591436
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

ODA Koji  Nagoya University, 医学系・研究科, 准教授 (30311715)

Co-Investigator(Kenkyū-buntansha) NAGINO Masato  名古屋大学, 大学院・医学系研究科, 教授 (20237564)
HAMAGUCHI Michinari  名古屋大学, 大学院・医学系研究科, 教授 (90135351)
二村 雄次  名古屋大学, 大学院医学系研究科, 教授 (80126888)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordscancer stem cell / circulating tumor cell / Circulating Tumor Cell / stem cell / p63 / Tyramide signal amplification system
Research Abstract

cancer stem cell markerを用いた癌組織における免疫組織学的染色の結果, Cancer stem cellおよびprogenitor cellを多く発現した腫瘍は治療抵抗性で予後不良であることが示された.
再発進行癌患者の末梢血液中に浮遊する癌細胞を採取し, cancer stem cell markerが陽性である癌細胞が同定された.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report

Research Products

(3 results)

All 2008 2007 2006

All Presentation (3 results)

  • [Presentation] IMMUNOHISTOCHEMICAL EXPRESSION OF OCT4 AND P63 PROTEIN, A PARAMETER OF MALIGNANT POTENTIAL IN COLORECTAL CARCINOMAS2008

    • Author(s)
      Yamamoto T. Yamamoto H. Oda K. Hayakawa N
    • Organizer
      16^<th>. United European Gastroenterology WeeK
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2008-10-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 膵癌におけるOct-3/4, p63蛋白発現についての検討2007

    • Author(s)
      山本竜義, 他
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression of p63 is a useful indicator of poor prognosis after resection in adenocarcinomas of the gallbladder and pancreas2006

    • Author(s)
      Tatsuyoshi Yamamoto, Koji Oda, Hideo Yamamoto, Naokazu Hayakawa, Masato Nagino, Yuji Nimura
    • Organizer
      7^<th> World congress of IHPBA
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      2006-09-06
    • Related Report
      2008 Final Research Report

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Published: 2006-03-31   Modified: 2016-04-21  

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