Study on anti-cancer immunotherapy targeting a tumor marker, SCCA

• Project/Area Number: 18591449
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Shimane University
• Principal Investigator: HARADA Mamoru Shimane University, 医学部, 教授 (50260716)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,930,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥630,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 癌 / 抗原 / 免疫学 / ペプチド

Research Abstract

上皮性癌の腫瘍マーカーとして知られている扁平上皮癌抗原(SCCA)を標的とした癌ペプチドワクチン療法を確立するために、日本人の6割が発現するHLA-A24分子と日本人の4割が発現するHLA-A2分子陽性癌患者に対する癌ワクチン療法に応用できるSCCA由来ペプチドの同定を試みた。その結果、HLA-A24分子陽性癌患者に利用できるSCCAペプチドを2個同定でき、上皮性癌患者に対するSCCAを標的とした癌ワクチン療法の可能性が示唆された。

Research Products

• [Journal Article] Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the anitumor effect after cyclophosphamide-using nonmyeloablative allogenenic hematopoietic cell transplantation in mice. (2009)
  • Author(s): Hamaguchi M, Harada M, et al..(10人中8番目)
  • Journal Title: Cancer Science 100 Pages: 138-143
  • Peer Reviewed
• [Journal Article] Roles of proinflammatory cytokines and theFas/FasL interaction in pathogenesis ofInflammatory myopathies. (2009)
  • Author(s): Kondo M, Harada M. et al.(6人中6番目)
  • Journal Title: Immunology in press Pages: 0-0
  • Peer Reviewed
• [Journal Article] Allogene ic cell therapy from immunized donors with tumor ant igen pept ide enhances the antitumor effect after cyclophosphamide-US ing nonmyeloablative allogeneic hematopoietic cell transplantation (2009)
  • Author(s): Hamaguchi, M.
  • Journal Title: Cancer Science 100 Pages: 138-143
  • Peer Reviewed
• [Journal Article] Roles of proinflammatory cytokines and the Fas/FasL interaction on the pathogenesis of inflammatorymyopathi es (2009)
  • Author(s): Kondo, M.
  • Journal Title: Immunology (印刷中)
  • Peer Reviewed
• [Journal Article] Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor. (2008)
  • Author(s): Eto M, Harada M,et al.(12人中6番目)
  • Journal Title: Clinical Cancer Research 14 Pages: 2833-2840
  • Peer Reviewed
• [Journal Article] Identification of Eph6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients (2008)
  • Author(s): Jin M, Harada M,et al.(9人中4番目)
  • Journal Title: Oncology Reports 19 Pages: 1277-1283
  • Peer Reviewed
• [Journal Article] A correlation between symptom severity and unbalanced reactive IgA production in Japanese ceder pollinosis patients. (2008)
  • Author(s): Komatsu N, Harada M,et al.(8人中2番目)
  • Journal Title: Asian Pacific Journal of Allergy and Immunology 26 Pages: 97-104
  • Peer Reviewed
• [Journal Article] Posttransplant admini strat ion of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor (2008)
  • Author(s): Eto, M.
  • Journal Title: Clinical Cancer Research 14 Pages: 2833-2840
  • Peer Reviewed
• [Journal Article] Identification of Eph6 variant-derived epi tope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients (2008)
  • Author(s): Jin, M.
  • Journal Title: Oncology Reports 19 Pages: 1277-1283
  • Peer Reviewed
• [Journal Article] A correlation between symptom severity and unbalanced reactive IgA. production in Japanese ceder polliosis patients (2008)
  • Author(s): Komatsu, N.
  • Journal Title: As ian pacific journal of Allergy and Immunology 26 Pages: 97-104
  • Peer Reviewed
• [Journal Article] Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in HLA-A24^+ glioma patients. (2007)
  • Author(s): Harada M, et al.(4人中1番目)
  • Journal Title: Oncology Reports 17 Pages: 629-636
  • Peer Reviewed
• [Journal Article] Cyclophosphamide-using nonmyeloablative allogeneic cell therapy against renal cancer with a reduced risk of graft-versus-host disease. (2007)
  • Author(s): Eto M, Harada M, et al.(10人中4番目)
  • Journal Title: Clinical Cancer Research 13 Pages: 1029-1035
  • Peer Reviewed
• [Journal Article] Identification of target antigens in specific immunotherapy for renal cell carcinoma (2007)
  • Author(s): Komohara Y, Harada M, et al.(8人中2番目)
  • Journal Title: Journal of Urology 177 Pages: 1157-1162
  • Peer Reviewed
• [Journal Article] Identification of SART3-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from prostate cancer patients with HLA-A3 supertype alleles (2007)
  • Author(s): Minami T, Harada M. et al.(8人中8番目)
  • Journal Title: Cancer Immunology Immunotherapy 56 Pages: 689-698
  • Peer Reviewed
• [Journal Article] New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype allelels. (2007)
  • Author(s): Matsueda S, Harada M. et al.(8人中8番目)
  • Journal Title: Journal of Immunotherapy 30 Pages: 274-281
  • Peer Reviewed
• [Journal Article] Combination therapy of personalized peptide vaccination and low-dose estramustine phosphate for metastatic hormone refractory prostate cancer patients: An analysis of prognostic factors in the treatment (2007)
  • Author(s): Noguchi M, Harada M,et al.(10人中7番目)
  • Journal Title: Oncology Research 16 Pages: 341-349
  • Peer Reviewed
• [Journal Article] Immunological evaluation of neoadjuvant peptide vaccination before radical prostatectomy for patients with localized prostate cancer. (2007)
  • Author(s): Noguchi M, Harada M, et al.(6人中3番目)
  • Journal Title: Prostate 67 Pages: 933-942
  • Peer Reviewed
• [Journal Article] Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative (TS-1) for advanced gastric or colorectal carcinoma patients. (2007)
  • Author(s): Sato Y, Harada M, et al.(14人中13番目)
  • Journal Title: Cancer Science 98 Pages: 1113-1119
  • Peer Reviewed
• [Journal Article] Differential levels of human leukocyte antigen-class I, multidrug-resistance 1 and androgen receptor expressions in untreated prostate cancer cells: The robustness of prostate cancer. (2007)
  • Author(s): Homma S, Harada M,et al.(7人中3番目)
  • Journal Title: Oncology Reports 18 Pages: 343-346
  • Peer Reviewed
• [Journal Article] peptides of the polycomb group protein enhancer of zeste homolog 2 (EZH2) with the potential to induce cancer-reactive cytotoxic T lymphocytes in HLA-A2^+ prostate cancer patients. (2007)
  • Author(s): Itoh Y, Harada M. et al.(8人中8番目)
  • Journal Title: Oncology Reports 18 Pages: 1231-1237
  • Peer Reviewed
• [Journal Article] HLA-G as a target molecule in specific immunotherapy against renal cell carcinoma (2007)
  • Author(s): Komohara Y, Harada M,et al.(8人中2番目)
  • Journal Title: Oncology Reports 18 Pages: 1463-1468
  • Peer Reviewed
• [Journal Article] Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles (2007)
  • Author(s): Naito M, Harada M. et al.(9人中9番目)
  • Journal Title: British Journal of Cancer 97 Pages: 1648-1654
  • Peer Reviewed
• [Journal Article] Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in HLA-A24+ glioma patients (2007)
  • Author(s): Harada, M.
  • Journal Title: Oncology Reports 17 Pages: 629-636
  • Peer Reviewed
• [Journal Article] Cyclophosphamide-using nonmyeloablative allogenenic cell therapy against renal cancer with a reduced risk of graft-versus-host disease (2007)
  • Author(s): Eto, M.
  • Journal Title: Clinical Cancer Research 13 Pages: 1029-1035
  • Peer Reviewed
• [Journal Article] Induction of target antigens in specific immunotherapy for renal cell carcinoma (2007)
  • Author(s): Komohaxa, Y.
  • Journal Title: Journal of Urology 177 Pages: 1157-1162
  • Peer Reviewed
• [Journal Article] Identification of SART3-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from prostate cancer patients with HLA-A3 supertype alleles (2007)
  • Author(s): Minami, T.
  • Journal Title: Cancer Immunology Immunotheragy 56 Pages: 689-698
  • Peer Reviewed
• [Journal Article] New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles (2007)
  • Author(s): Mtsueda, S.
  • Journal Title: Journal of Immunotherapy 30 Pages: 274-281
  • Peer Reviewed
• [Journal Article] Combination therapy of personalized peptide vaccination and low-dose estramustine phosphate for metastatic hormone refractory prostate, cancer patients (2007)
  • Author(s): Noguchi, M.
  • Journal Title: Oncology Research 16 Pages: 341-349
  • Peer Reviewed
• [Journal Article] Immunological evaluation of neoadjuvant peptide vaccination before radical prostatectomy for patients with localized prostate cancer (2007)
  • Author(s): Noguchi, M.
  • Journal Title: Prostate 67 Pages: 933-942
  • Peer Reviewed
• [Journal Article] Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative(TS-1)for advanced gastric or colorectal carcinoma patients (2007)
  • Author(s): Sato, Y.
  • Journal Title: Cancer Science 98 Pages: 1113-1119
  • Peer Reviewed
• [Journal Article] Differential levels of human leukocyte-antigen-class I, multipledrug-resistance I and androgen receptor expression in untreated prostate cancer cells (2007)
  • Author(s): Homma, S.
  • Journal Title: Oncology Reports 18 Pages: 343-346
  • Peer Reviewed
• [Journal Article] New peptides of the polycomb group protein enhancer of zeste homolog 2(EZH2)with the potential to induce cancer-reactive cytotoxic T lymphocytes in NLA-A2+ prostate cancer patients (2007)
  • Author(s): Itoh, Y.
  • Journal Title: Oncology Reports 18 Pages: 1231-1237
  • Peer Reviewed
• [Journal Article] HLA-G as a target molecule in specific immunotherapy against renal cell carcinoma (2007)
  • Author(s): Komohara, Y.
  • Journal Title: Oncology Reports 18 Pages: 1463-1468
  • Peer Reviewed
• [Journal Article] Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles (2007)
  • Author(s): Naito, M.
  • Journal Title: British Journal of Cancer 97 Pages: 1648-1654
  • Peer Reviewed
• [Journal Article] Prostate-specific antigen-reactive cytotoxic T lymphocyte precursors in colon cancer patients (2006)
  • Author(s): Wang Y, Harada M,et al.(7人中2番目)
  • Journal Title: Oncology Reports 15 Pages: 317-321
  • NAID: 120005587482
  • Peer Reviewed
• [Journal Article] Anti-tumor effect of systemic and local immunization with a cytotoxic T lymphocyte-directed peptide in combination with a local injection of OK-432 (2006)
  • Author(s): Ono T, Harada M, et al.(10人中2番目)
  • Journal Title: Clinical Cancer Research 12 Pages: 1325-1332
• [Journal Article] In vivo growth of transitional and renal carcinoma cell lines can be suppressed by adenovirus-mediated expression of a solubleform of vascular endothelial growth factor receptor (2006)
  • Author(s): Ichikura H, Harada M,et al.(8人中4番目)
  • Journal Title: Oncology Reports 15 Pages: 1333-1337
  • Peer Reviewed
• [Journal Article] Identification of squamous cell carcinoma antigen-derived peptides having the capacity of inducing cancer-reactive CTLs in HLA-A24^+ cancer patients (2006)
  • Author(s): Homma, Harada M,et al.(2人中12番目)
  • Journal Title: International Journal of Oncology 29 Pages: 577-587
  • NAID: 120005587483
  • Peer Reviewed
• [Journal Article] Identification of Hepatitis C virus (HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24^+ and HCV2a-infected patients (2006)
  • Author(s): Wang Y, Harada M, et al.(3人中8番目)
  • Journal Title: Cellular Immunology 241 Pages: 38-46
• [Journal Article] Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma (2006)
  • Author(s): Komohara Y, Harada M, et al.(2人中8番目)
  • Journal Title: International Journal of Oncology 29 Pages: 1555-60
  • NAID: 120005587481
  • Peer Reviewed
• [Journal Article] new epitope peptides derived from Hepatitis C virus (HCV) 2a which have the capacity to induce cytotoxic T lymphocytes in HLA- A2^+ HCV-infected patients (2006)
  • Author(s): Wang Y, Harada M, et al.(8人中3番目)
  • Journal Title: Microbiol. Immunol 50 Pages: 857-865
  • NAID: 10018398215
  • Peer Reviewed
• [Journal Article] Prostate-specific antigen-reactive cytotoxic T lymphocyte precursors in colon cancer patients (2006)
  • Author(s): Wang, Y.
  • Journal Title: Oncol.Reports 15 Pages: 317-321
• [Journal Article] Anti-tumor effect of systemic and local immunization with a cytotoxic T lymphocyte-directed peptide in combination with a local injection of OK-432 (2006)
  • Author(s): Ono, T
  • Journal Title: Clinical Cancer Res. 12 Pages: 1325-1332
• [Journal Article] In vivo growth of transitional and renal carcinoma cell lines can be suppressed by adenovirus-mediated expression of a soluble from of vascular endothelial growth factor receptor (2006)
  • Author(s): Ichikura, H.
  • Journal Title: Oncol,Reports 15 Pages: 1333-1337
• [Journal Article] Identification of squamous cell carcinoma antigen-derived peptides having the capacity of inducing cancer-reactive CTLs in HLA-A24+ cancer patients (2006)
  • Author(s): Honma, S.
  • Journal Title: Int.J.Oncol. 29 Pages: 577-587
• [Journal Article] Identification of hepatitis C virus(HCV)2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24+ and HCV2a-infected patients (2006)
  • Author(s): Wang, Y.
  • Journal Title: Cell.Immunol. 241 Pages: 38-46
• [Journal Article] Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma (2006)
  • Author(s): Komohara, Y.
  • Journal Title: Int.J.Oncol. 29 Pages: 1555-1560
• [Presentation] Roles of proinflammatory cytokines and Fas in the pathogenes is of inflammatory myopathies (2008)
  • Author(s): Kondo, M.
  • Organizer: 第3 8回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Cyclophosphamideとadriamycinによる抗がん免疫応答の増強 (2008)
  • Author(s): 頓宮 美樹
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識する新規腫瘍抗原の同定とその発現 (2008)
  • Author(s): 原田守
  • Organizer: 第12回基盤的癌免疫研究会総会
  • Place of Presentation: 埼玉
• [Presentation] Cyclophosphamideとadriacycinによる抗がん免疫応答の増強 (2008)
  • Author(s): 原田守
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Roles of pro- inflammatory cytokines and Fas in the pathogenesis of inflammatory myopathies (2008)
  • Author(s): HARADA Mamoru
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
• [Presentation] Evidence of the extrathymic development of tyrosinase-related protein(TRP)2-recognizing CD8+T cells with Iow avidity (2007)
  • Author(s): Harada, M.
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Vaccination of donors with tumor antigen peptides enhances antitumor effects in nonmyeloablative allogenenic cell therapy (2007)
  • Author(s): Eto, M.
  • Organizer: 第66回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Vaccination of donors with tumor antigen peptides enhances antitumor effects in nonmyeloablative allogenenic cell therapy (2007)
  • Author(s): HARADA Mamoru
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
• [Presentation] TRP2 を認識するlow avidity CD8+ T細胞の胸腺外分化/Evidence of the extrathymic development of tyrosinae-related protein (TRP)2-recognizing CD8+ T cells with low avidity (2007)
  • Author(s): HARADA Mamoru
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
• [Presentation] 未治療前立腺癌組織でのHLAクラスI,MRP1とアンドロゲンレセプター発現の検討 (2006)
  • Author(s): 原田守
  • Organizer: 第65回日本癌学会学術集総会
  • Place of Presentation: 横浜
• [Presentation] 腎癌・膀胱癌に対するワクチン療法に有用な抗原ペプチドの検討 (2006)
  • Author(s): 原田守
  • Organizer: 第65回日本癌学会学術集総会
  • Place of Presentation: 横浜
• [Presentation] 前立腺癌患者再燃早期におけるテーラーメイドペプチドワクチン療法の可能性 (2006)
  • Author(s): 原田守
  • Organizer: 第65回日本癌学会学術集総会
  • Place of Presentation: 横浜
• [Presentation] Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive CTLs in HLA-A24+ glioma patients (2006)
  • Author(s): HARADA mamoru
  • Organizer: 第36回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Identification of SART3- derived peptides having the potential to induce cancer-reactive CTLs from prostate cancer patients with HLA-A3 supertype alleles (2006)
  • Author(s): HARADA Mamoru
  • Organizer: 第36回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪