Molecular mechanisms of solid tumor growth inhibition by a new differentiation inducer

• Project/Area Number: 18591450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Research Institute for Clinical Oncology, Saitama Cancer Center
• Principal Investigator: KASUKABE Takashi Research Institute for Clinical Oncology, Saitama Cancer Center, 臨床腫瘍研究所, 主幹 (50152658)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,060,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: Cotylenin A, Rapamycin / 分化誘導剤乳 / 乳癌細胞 / 増殖抑制 / G1 arrest / cDNAmicroarray / Cyclin G2 / Cotvlenin A / Rapamycin / 分化誘導剤 / セルシグナリング / Akt / mToR / Cotylenin A / cyclin G2 / siRNA / cDNA microarray

Research Abstract

本研究は白血病細胞の新規分化誘導剤が固形癌細胞への増殖抑制効果を発揮する可能性があること、およびその分子的基盤を明らかにし、新しい作用機序による固形癌の治療法を確立することを目的とした。
その結果、我々が新たに見出した分化誘導剤 cotylenin A はrapamycinと相乗的にヒト乳癌細胞の増殖を顕著に抑制することを見出した。
また、この作用機序には、サイクリンG2 が関与していることを見出した。

Research Products

• [Journal Article] Cancer Sci (2008)
  • Author(s): Kasukabe, T., Okabe-Kado, J., Honma, Y. Cotylenin A
  • Journal Title: new differentiation inducer,and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2 99 Pages: 1693-1698
  • Peer Reviewed
• [Journal Article] Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2 (2008)
  • Author(s): Kasukabe T.
  • Journal Title: Cancer Science 99 Pages: 1693-1698
  • NAID: 10024010291
  • Peer Reviewed
• [Journal Article] Cotylenin A,a new differentiation inducer,and rapamycin cooperatively inhibit growth of cancer cells through induction of cychn G2. (2008)
  • Author(s): Kasukabe, T.
  • Journal Title: Cancer Science 99(印刷中)
  • Peer Reviewed
• [Journal Article] Cotylenin A-induced differentiation isindependent of the transforming growth factor-b signaling system in human myeloid leukemia HL-60 cells (2006)
  • Author(s): Matunawa, M., Ishii, Y., Kasukabe, T., Tomoyasu, S., Ota, H., Honma, Y.
  • Journal Title: Leukemia & Lymphoma 47 Pages: 733-740
  • Peer Reviewed
• [Journal Article] Cotylenin A-induced differentiation is independent of the transforming growth factor-β signaling system in human myeloid leukemia HL-60 cells (2006)
  • Author(s): Matsunawa, M, Ishii, Y, Kasukabe, T, Tomoyasu, S, Ota, H, Honma, Y
  • Journal Title: Leukemia ＆ Lymphoma 47 Pages: 733-740
• [Presentation] Inhibition ofrapamycin-induced Akt phosphorylation by cotylenin A correlated their growth inhibition of cancer cells (2008)
  • Author(s): 粕壁 隆, 他2 名
  • Organizer: 第67 回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Inhibition of rapamycin-induced Akt phosphorylation by cotylenin A correlated their growth inhibition of cancer cells (2008)
  • Author(s): 粕壁隆
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Cotylenin A, a differentiation-induing agent, inhibits rapamycin-induced feedback activation of Akt signaling (2007)
  • Author(s): 粕壁 隆, 他2 名
  • Organizer: 第66 回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Cotylenin A,a differentiation agent,inhibits rapamycin-induced feedback activation of Akt signaling (2007)
  • Author(s): 粕壁 隆
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] 分化誘導剤cotylenin Aとrapamycin のヒト乳癌細胞に対する増殖抑制とcyclin G2 発現誘導 (2006)
  • Author(s): 粕壁 隆, 他2 名
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-30
• [Presentation] 分化誘導剤cotylenin Aとrapamycin によるヒト乳癌細胞の増殖抑制とcyclin G2 発現誘導 (2006)
  • Author(s): 粕壁 隆, 他2 名
  • Organizer: 第10回がん分子標的治療研究会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-06-16
• [Book] Focus on Neuroblastoma Research (2007)
  • Author(s): Okabe-Kado, J., Kasukabe, T., Kaneko, Y
  • Publisher: NOVA Publishers
• [Book] Focus on Neuroblastoma Res. (2007)
  • Author(s): Okabe-Kado, J., Kasukabe, T., Kaneko, Y.
  • Publisher: NOVA Publishers
• [Book] Focus on Neuroblastoma Res. (2007)
  • Author(s): Okabe-kado, J, Kasukabe, T, Kaneko, Y
  • Publisher: NOVA Publishers (印刷中)
• [Remarks]
  • URL: http://www.pref.saitama.lg.jp/A80/BA02/top.htm
• [Remarks]
  • URL: http://www.pref.saitama.lg.jp/A80/BA02/top.htm
• [Remarks]
  • URL: http://www.pref.saitama.lg.jp/A80/BAO2/top.htm