| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
Background and Goals: The aim of this study was to evaluate the gastric motor function by magnetic resonance imaging (MRI), and it investigated whether this examination is a useful tool for therapeutic efficacy or postoperative gastric motor function.
Methods: Twenty-five healthy volunteers and 10 gastric cancer patients with pylorus-preserving gastrectomy (PPG) underwent cine-MRIs. Gastric volume was determined by 3D-volumetry. Gastric motility was quantified by calculating the gastric motility index (GMI).
Results: The image acquisition and analysis were successfully performed for all subjects. In healthy volunteers, the mean frequency, amplitude, velocity of gastric peristaltic waves, and GMI 30 minutes after the intake of jelly were 3/min, 8.8mm, 2.2mm/s, and 19.6mm2/s, respectively. The mean amplitude (8.8 vs. 10.4 mm, p=0.027), velocity (2.2 vs.2.6 mm/s, p<0.001) of peristaltic waves, GMI (19.6 vs.26.7 mm2/s, p<0.001), and gastric emptying rate (18.2vs.27.5%, p=0.004) significantly increased at 30 minutes after mosapride citrate administration. PPG patients with postprandial symptoms were observed having antiperistalsis-like contraction waves and reflux of gastric contents from the pyloric region into the upper part of the stomach. The mean gastric emptying rate in PPG patients with postprandial symptoms at 30 minutes after the intake of jelly tended to be less than in those without such symptoms(9.9vs.22.1%).
Conclusions: The present study demonstrates that cine-MRI is a sensitive and noninvasive imaging technique for simultaneously measuring gastric motility and emptying.
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