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EXPRESSION OF THE TYPE III INOSITOL 1, 4, 5 TRIPHOSPHATE RECEPTOR IS A NOVEL MARKER TO EVALUATE MALIGNANT POTENTIAL IN COLORECTAL CARCINOMA

Research Project

Project/Area Number 18591490
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SHIBAO Kazunori  University of Occupational and Environmental Health, Japan, Sch. of Med., Assistant Prof. (10330987)

Co-Investigator(Kenkyū-buntansha) NAGATA Naoki  University of Occupational&Environmental Health, Sch. of Med., Associate Prof. (80200377)
HIRATA Kenji  University of Occupational&Environmental Health, Sch. of Med., Assistant Prof. (70269059)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsIP3 receptor / colorectal cancer / cell proliferation / calcium signaling / apoptosis
Research Abstract

The InsP3 receptor (Ca^<2+> signaling) is important for cell proliferation. There are three isoforms of the inositol 1, 4, 5-trisphosphate receptor (InsP3R).
In this study, we asked whether each isoform of InsP3R expression is associated with the clinico-pathological futures. METHODS: In 19 paraffin embedded specimens from surgically resected colorectal carcinomas, each isoform of InsP3R and Ki-67 were evaluated by immunohistochernistry. RESULTS: Cytoplasmic expression of type I and type II InsP3Rs were observed in human colorectal mucosa mostly in their apical half. But no type HI InsP3R expression was observed in colorectal mucosa. Meanwhile, all isoforms of InsP3R including type InsP3R were expressed in human colorectal cancer. Type I and type II InsP3R expression was not correlated to clinico-pathological futures including cell proliferation. The type III InsP3R expression was not associated with tumor size, tumor location, disease stage, or cell proliferation but was related to lymph node metastasis (P=0.020). CONCLUSIONS: The type HI InsP3R may be a potential candidate of biomarker for colorectal cancer and a possible therapeutic target for preventing tumor metastasis.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (3 results)

All 2007

All Presentation (3 results)

  • [Presentation] Expression of the type III Inositol 1, 4, 5 triphosphate receptor is a novel marker to evaluate malignant potential in colorectal2007

    • Author(s)
      Kazunori Shibao
    • Organizer
      The 62nd Annual Meetig of the Japan Society of Coloproctology
    • Place of Presentation
      Osaka
    • Year and Date
      2007-11-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸癌症例における3型イノシトール3リン酸レセプター発現の臨床病理学的検討2007

    • Author(s)
      柴尾 和徳
    • Organizer
      第107回日本外科学会
    • Place of Presentation
      大阪府
    • Year and Date
      2007-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of the type III Inositol 1, 4, 5 triphosphate receptor is a novel marker to evaluate malignant potential in colorectal2007

    • Author(s)
      Kazunori Shibao
    • Organizer
      The 107th Annual Congress of Japan Surgical Society
    • Place of Presentation
      Osaka
    • Year and Date
      2007-04-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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