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The early detection and clinical application of acute liver failure caused by major hepatectomy in the rat

Research Project

Project/Area Number 18591518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Miyazaki

Principal Investigator

甲斐 眞弘  University of Miyazaki, 医学部, 講師 (40264379)

Co-Investigator(Kenkyū-buntansha) 千々岩 一男  宮崎大学, 医学部, 教授 (90179945)
近藤 千博  宮崎大学, 医学部, 講師 (10244196)
大内田 次郎  宮崎大学, 医学部, 助教 (10363590)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords胆道外科学 / 有機アニオントランスポーター / 大量肝切除 / 肝不全 / トランスポーター / 閉塞性黄疸 / 胆汁酸
Research Abstract

胆道癌に対する拡大肝切除は, 術後の肝不全の誘因となりうる. 正確な残存肝予備能の把握と術後肝不全の早期予知およびその防止は臨床上重要な課題である. われわれは, 閉塞性黄疸ラットモデルおよび大量肝切除ラットモデルを用いてビリルビンおよび胆汁酸代謝や有機アニオントランスポーターの発現の変化を検討してきた. 閉塞性黄疸ラットモデルでの検討結果から, 胆汁外瘻と比較して胆汁内瘻による減黄の有用性が示唆された. また, 大量肝切除ラットモデルでの検討結果から, 肝切除術後の胆汁流量や胆汁酸排泄量の変化, 有機アニオントランスポーターの発現の変化が術後肝不全発症を早期に予知するうえでの指標となる可能性が示唆された.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (46 results)

All 2009 2008 2007 Other

All Journal Article (31 results) (of which Peer Reviewed: 7 results) Presentation (15 results)

  • [Journal Article] Prospective randomized controlled study of gastric emptying assessed by ^<13>C-acetate breath test after pylorus-preserving pancreaticoduodenectomy : Comparison between antecolic and vertical retrocolic duodenojejunostomy2009

    • Author(s)
      Chijiiwa K, Imamura N, Ohuchida J, Hiyoshi M, Nagano M, Otani K, Kai M and Kondo K
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 16(1)

      Pages: 49-55

    • Related Report
      2008 Final Research Report
  • [Journal Article] Surgical strategy for hepatocellular carcinoma patients with portal vein tumor thrombus based on prognostic factor2009

    • Author(s)
      Kondo K, Chijiiwa K, Kai M, Otani K, Nagaike K, Ohuchida J, Hiyoshi M and Nagano M
    • Journal Title

      Journal of Gastrointestinal Surgery 13(6)

      Pages: 1078-1083

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prospective randomized controlled siudy of gastric emptying assessed by 13_C-acetate breath test after pylorus-preservingpancreaticoduodenectomy : Comparison between antecolic andvertical retrocolic duodenojeiunostomy.2009

    • Author(s)
      Chijiiwa K, et. al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 16

      Pages: 49-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical strategy for hepatocellular carcinoma patients withportal vein tumor thrombus based on prognostic factor.2009

    • Author(s)
      Kondo K, et. al.
    • Journal Title

      Journal of Gastrointestinal Surgery 13

      Pages: 492-497

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in long-term outcome and prognostic factors according to viral status in patients with hepatocellular carcinoma treated by surgery2008

    • Author(s)
      Kondo K, Chijiiwa K, Funagayama M, Kai M, Otani K and Ohuchida J
    • Journal Title

      Journal of Gastrointestinal Surgery 12(3)

      Pages: 468-476

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hepatic resection is justified for elderly patients with hepatocellular carcinoma2008

    • Author(s)
      Kondo K, Chijiiwa K, Funagayama M, Kai M, Otani K and Ohuchida J
    • Journal Title

      World Journal of Surgery 32(10)

      Pages: 2223-2229

    • Related Report
      2008 Final Research Report
  • [Journal Article] Outcome of surgical treatment of hilar cholangiocarcinoma2008

    • Author(s)
      Otani K, Chijiiwa K, Kai M, Ohuchida J, Nagano M, Tsuchiya K and Kondo K
    • Journal Title

      Journal of Gastrointestinal Surgery 12(6)

      Pages: 1033-1040

    • Related Report
      2008 Final Research Report
  • [Journal Article] Unusual segmental stricture of the lower common bile duct mimicking bile duct cancer2008

    • Author(s)
      Uchiyama S, Chijiiwa K, Hiyoshi M, Ohuchida J, Kai M, Nagano M, Nagaike K, Kondo K, Akiyama Y and Kataoka H
    • Journal Title

      Journal of Gastrointestinal Surgery 12(1)

      Pages: 199-201

    • Related Report
      2008 Final Research Report
  • [Journal Article] 磁石圧迫吻合術後経過良好な術中胆道損傷による総肝管完全閉塞の1例2008

    • Author(s)
      旭吉雅秀, 千々岩一男, 大内田次郎, 今村直哉, 永野元章, 甲斐眞弘, 近藤千博
    • Journal Title

      胆道 22(4)

      Pages: 558-562

    • NAID

      10030905785

    • Related Report
      2008 Final Research Report
  • [Journal Article] Differences in long-term outcome and prognostic factors according to viral status in patients with hepatocelluralcarcinoma treated by surgery.2008

    • Author(s)
      Kondo K, et al.
    • Journal Title

      Journal of Gastrointestinal Surgery 12

      Pages: 468-476

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic resection is justified for elderly patients withhepatocellular carcinoma.2008

    • Author(s)
      Kondo K, et. al.
    • Journal Title

      World Journal of Surgery 32

      Pages: 2223-2229

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of surgical treatment of hi lar cholangiocarcinoma2008

    • Author(s)
      Otani K, et al.
    • Journal Title

      Journal of Gastrointestinal Surgery 12

      Pages: 1033-1040

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unusual segmental stricture of the lower common bile ductmimicking bile duct cancer.2008

    • Author(s)
      Uchiyama S, et. al.
    • Journal Title

      Journal of Gastrointestinal Surgery 12

      Pages: 199-201

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁石圧迫吻合術後経過良好な術中胆道損傷による総肝管完全閉塞の1例.2008

    • Author(s)
      旭吉雅秀, 他
    • Journal Title

      胆道 11

      Pages: 558-562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A curative resection improves the postoperative survival rate even in patients with advanced gallbladder carcinoma2007

    • Author(s)
      Kai M, Chijiiwa K, Ohuchida J, Nagano M, Hiyoshi M and Kondo K
    • Journal Title

      Journal of Gastrointestinal Surgery 11(8)

      Pages: 1025-1032

    • Related Report
      2008 Final Research Report
  • [Journal Article] 膵石症に対する体外衝撃波結石破砕療法(ESWL)2007

    • Author(s)
      甲斐眞弘, 千々岩一男, 長沼志興, 近藤千博, 大谷和広, 大内田次郎, 永野元章, 旭吉雅秀
    • Journal Title

      膵臓 22(6)

      Pages: 681-690

    • NAID

      10024367159

    • Related Report
      2008 Final Research Report
  • [Journal Article] Outcome of radical surgery for stage IV gallbladder carcinoma2007

    • Author(s)
      Chijiiwa K, Kai M, Nagano M., Hiyoshi M, Ohuchida J and Kondo K
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 14(4)

      Pages: 345-350

    • Related Report
      2008 Final Research Report
  • [Journal Article] Vertical retrocolic duodenojejunostomy decreases delayed gastric emptying after pylorus-preserving pancreatoduodenectomy2007

    • Author(s)
      Chijiiwa K, Ohuchida J, Hiyoshi M, Nagano M, Kai M and Kondo K
    • Journal Title

      Hepato-Gastroenterology 54(78)

      Pages: 1874-1877

    • Related Report
      2008 Final Research Report
  • [Journal Article] Comparison of seven prognostic staging systems in patients who undergo hepatectomy for hepatocellular carcinoma2007

    • Author(s)
      Kondo K, Chijiiwa K, Nagano M, Hiyoshi M, Kai M, Maehara N, Ohuchida J, Nakao H and Ohkawa Y
    • Journal Title

      Hepato-Gastroenterology 54(77)

      Pages: 1534-1538

    • Related Report
      2008 Final Research Report
  • [Journal Article] Mucin-producing bile duct tumor of the caudate lobe protruding into the common hepatic duct2007

    • Author(s)
      Uchiyama S, Chijiiwa K, Hiyoshi M, Nagano M, Ohuchida J, Nagaike K, Kai M. and Kondo K
    • Journal Title

      Journal of Gastrointestinal Surgery 11(11)

      Pages: 1570-1572

    • Related Report
      2008 Final Research Report
  • [Journal Article] A curative resection improves the postoperative surgical rate even in patients with advanced gallbladder carcinoma.2007

    • Author(s)
      Kai, M., et. al.
    • Journal Title

      Journal of Gastrointestinal Surgery 11(8)

      Pages: 1025-1032

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 膵石症に対する体外衝撃波結石破砕療法(ESWL).2007

    • Author(s)
      甲斐真弘, 他
    • Journal Title

      膵臓 22(6)

      Pages: 681-690

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Outcome of radical surgery for stage IV gallbladder carcinoma.2007

    • Author(s)
      Chijiiwa, K., et. al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 14(4)

      Pages: 345-350

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Vertical retrocolic duodenojejunostomy decreases delayed gastric emptying after pylorus-preserving pancreatoduodenectomy.2007

    • Author(s)
      Chijiiwa, K., et. al.
    • Journal Title

      Hepato-Gastroenterology 54(78)

      Pages: 1874-1877

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Comparison of seven prognostic staging systems in patients who undergo hepatectomy for hepatocellular carcinoma.2007

    • Author(s)
      Kondo, K., et. al.
    • Journal Title

      Hepato-Gastroenterology 54(77)

      Pages: 1534-1538

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Mucin-producing bile duct tumor of the caudate lobe protruding into the common hepatic duct.2007

    • Author(s)
      Uchiyama, S., et. al.
    • Journal Title

      Journal of Gastrointestinal Surgery 11(11)

      Pages: 1570-1572

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A curative resection improve the postoperative surgical rate even in patients with advanced gallbladder carcinoma.

    • Author(s)
      Kai, M.et al.
    • Journal Title

      Journal of Gastrointestinal Surgery (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Compariso Chijiiwa, K. n of seven prognostic staging systems in patients who undergo hepatectomy for hepatocellular carcinoma.

    • Author(s)
      Kondo, K. et al.
    • Journal Title

      Hepato-Gastroenterology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Vertical retrocolic duodenojejunostomy decreases delayed gastric emptying after pylorus preserving pancreatoduodenectomy.

    • Author(s)
      Chijiiwa, K. et al.
    • Journal Title

      Hepato-Gastroenterology (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Outcome of radical surgery for stage IV gallbladder carcinoma.

    • Author(s)
      Chijiiwa, K. et al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Medical Students' Attitudes to Laparoscopic Surgery.

    • Author(s)
      Hotokezaka, M. et al.
    • Journal Title

      Hepato-Gastroenterology (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Prognostic factors and diagnosis of extent of the bile duct cancer.2009

    • Author(s)
      Kai M, et. al.
    • Organizer
      2^<nd> Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] The indicat ion of bile duct resect ion without hepatectomyfor treatment of hilar cholangiocarcinoma.2009

    • Author(s)
      Otani K, et. al.
    • Organizer
      2^<nd> Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prognostic factors and diagnosis of extent of the bile duct cancer2009

    • Author(s)
      Kai M, Chijiiwa K and Otani K
    • Organizer
      2nd Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2008 Final Research Report
  • [Presentation] The indication of bile duct resection without hepatectomy for treatment of hilar cholangiocarcinoma2009

    • Author(s)
      Otani K, Chijiiwa K, Kai M, Nagano M and Ohuchida J
    • Organizer
      2nd Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Bangkok
    • Related Report
      2008 Final Research Report
  • [Presentation] 術後良性胆道狭窄の病態と病態に応じた至適治療法の検討.2008

    • Author(s)
      甲斐真弘, 他
    • Organizer
      第44回日本胆道学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胆嚢癌における進展度別外科治療の問題と対策.2008

    • Author(s)
      甲斐真弘, 他
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行胆嚢癌の進行度別生存率と長期生存例からみた至適術式の検討.2008

    • Author(s)
      甲斐真弘, 他
    • Organizer
      第20回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      山形
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行胆嚢癌長期生存例から至適術式の検討.2008

    • Author(s)
      甲斐真弘, 他
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] pT2胆嚢癌における術式選択2008

    • Author(s)
      甲斐眞弘, 千々岩一男, 永野元章, 大内田次郎, 近藤千博, 大谷和広, 長池幸樹, 旭吉雅秀, 今村直哉
    • Organizer
      第70回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 術後良性胆道狭窄の病態と病態に応じた至適治療法の検討2008

    • Author(s)
      甲斐眞弘, 千々岩一男, 旭吉雅秀, 大内田次郎, 近藤千博, 大谷和広, 長池幸樹, 永野元章, 今村直哉, 矢野公一
    • Organizer
      第44回日本胆道学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 胆嚢癌における進展度別外科治療の問題と対策2008

    • Author(s)
      甲斐眞弘, 千々岩一男, 永野元章, 大内田次郎, 近藤千博, 大谷和広, 佐野浩一郎, 旭吉雅秀, 今村直哉, 矢野公一
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行胆嚢癌の進行度別生存率と長期生存例からみた至適術式の検討2008

    • Author(s)
      甲斐眞弘, 千々岩一男, 永野元章, 大内田次郎, 近藤千博, 大谷和広, 佐野浩一郎, 内山周一郎, 旭吉雅秀, 今村直哉, 矢野公一
    • Organizer
      第20回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      山形
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行胆嚢癌長期生存例から至適術式の検討2008

    • Author(s)
      甲斐眞弘, 千々岩一男, 永野元章, 大内田次郎, 近藤千博, 大谷和広, 佐野浩一郎, 内山周一郎, 旭吉雅秀, 今村直哉, 矢野公一
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinicopathological analysis of ampullary lesions treated by wide ampullectomy2008

    • Author(s)
      Uchiyama S, Chijiiwa K, Hiyoshi M, Imamura N, Nagano M, Ohuchida J, Nagaike K, Kai M and Kondo K
    • Organizer
      8th World Congress of the International Hepato Pancreato Biliary Association
    • Place of Presentation
      Mumbai
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinicopathological analysis of lymph node metastases in cases of the cancer of the major duodenal papilla2008

    • Author(s)
      Nagaike K, Chijiiwa K, Uchiyama S, Nagano M, Hiyoshi M, Ohuchida J, Kai M and Kondo K
    • Organizer
      8th World Congress of the International Hepato Pancreato Biliary Association
    • Place of Presentation
      Mumbai
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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