The effect of pulmonary isolation on the initiation and sustenance of atrial fibrillation induced in left atrial, volume-load model
| Project/Area Number |
18591565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
NITTA Takashi Nippon Medical School, School of Medicine, Professor (40256954)
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| Co-Investigator(Kenkyū-buntansha) |
KANNO Shigeto Nippon Medical School, School of Medicine, Assistant Professor (20291718)
ISHII Yosuke Nippon Medical School, School of Medicine, Fellow (10307895)
OGNIRI Hiroya Nippon Medical School, School of Medicine, Fellow (40343587)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Atrial fibrillation / Pulmonary vein / Volume load / Left atrium / 左房容量負荷 |
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| Research Abstract |
Effect of pulmonary isolation on the initiation and sustenance of atrial fibrillation was studied in canine left atrial volume-load model. A shunt was made between the left subclavian artery and the left pulmonary artery in mongrel dogs. All the animals exhibited severe heart failure postoperatively. Some animals died of severe heart failure. Rapid pacing at the left atrial appendage was initiated one week after the shunt surgery. The animals survived for 4 weeks were subjected to the pulmonary vein mapping study.
Continuous atrial fibrillation was observed in all animals. The cycle length of the left atrial electrograms was shorter than that of the right atrial electrograms. The cycle length progressively shortened during the 4 weeks. Atrial activation maps during atrial fibrillation showed repetitive activation originated from the right and left superior pulmonary veins and fibrillatory conduction to the right atrium. Pulmonary vein isolation was performed by means of bipolar radiofrequency ablation device. Atrial fibrillation was not terminated in any animals.
In addition to the repetitive activation in the pulmonary veins, atrial reentrant activations or non-pulmonary vein abnormal activations might have played a role in the sustenance of atrial fibrillation in the left atrial volume-load model.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Histopathological Features of the Resected Left Atrial Appendage as Predictors of Recurrence After Surgery for Atrial Fibrillation in Valvular Heart Disease.2007
Author(s)
Saito, T., Tamura, K., Uchida, D., Saito, T., Togashi, M., Nitta, T., Sugisaki, Y
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Journal Title
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Histopathological evaluation of left atrial appendage thrombogenesis removed during surgery for atrial fibrillation2007
Author(s)
Saito, T., Tamura, K., Uchida, D., Saito, T., Nitta, T., Sugisaki, Y
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Journal Title
Am Heart J 153
Pages: 704-711
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Use of Bipolar Radiofrequency Ablation Devices Does Not Undermine the Efficacy of Surgery for AF2007
Author(s)
Ishii, Y., Bessho, R., Fujii, M., Ohmori, H., Kambe, M., Kurita, J., Ochi, M., Shimizu, K
Organizer
Twenty-eighth Heart Rhythm Society
Place of Presentation
Denver, CO
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Electroanatomical mapping-guided implantation of atrial pacemaker leads in idiopathic atrialfibrosis presenting partial atrial standstill and complete atrioventricular block : Improvement of left atrial contractility by achievement of A-V synchrony2007
Author(s)
Miyauchi, Y., Kobayashi, Y., Maruyama, M., Iwasaki, Y., Hirasawa, Y., Ueno, A., Okazaki, R., Murata, H., Ohara, T., Nitta, T., Katoh, T., Takano, T
Organizer
Twenty-eighth Heart Rhythm Society
Place of Presentation
Denver, CO
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] The Mechanisms and Radiofrequency Catheter Ablation of Atrial Tachycardia Following Surgery for Atrial Fibrillation.2006
Author(s)
Miyauchi, Y., Kobayashi, Y., Nitta, T., Maruyama, M., Iwasaki, Y., Horie, T., Taniguchi, H., Ueno, A., Tateoka, K., Okazaki, R., Hayashi, M., Ishii, Y., Katoh, T., Takano, T
Organizer
Twenty-seventh Heart Rhythm Society
Place of Presentation
Boston, MA
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Atrial Fibrillation Associated with an Atrial Septal Defect : The Mechanism and Optimal Lesion Set for Ablation.2006
Author(s)
Nitta, T., Ishii, Y., Bessho, R., Fujii, M., Ohmori, H., Kambe, M., Kurita, J., Ochi, M., Shimizu, K
Organizer
Twenty-seventh Heart Rhythm Society
Place of Presentation
Boston, MA
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Use of alternative ablation devices does not undermine the efficacy of AF surgery.2006
Author(s)
Nitta, T., Ishii, Y., Bessho, R., Fujii, M., Ohmori, H., Kambe, M., Kurita, J., Ochi, M., Shimizu, K
Organizer
Nineteenth World Society of Cardio-Thoracic Surgeons
Place of Presentation
Kanazawa
Description
「研究成果報告書概要(欧文)」より
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