Amelioration of ischemic neuronal by angiotensin receptor control

• Project/Area Number: 18591574
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Akita University
• Principal Investigator: SUGAWARA Taku Akita University, Akita University School of Medicine, Lecturer (80241660)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: global cerebral ischemia / hippocampal neurons / apoptosis / oxidative stress / superoxide / angiotensin II / DNA損傷 / 海馬CA1領域 / アンジオテンシン受容体

Research Abstract

Excessive superoxide production after cerebral ischemia is known to mediate neuronal injury. Angiotensin II type 1 receptor activation results in production of superoxide, but whether angiotensin II type 1 receptor blockade prevents production of superoxide and subsequent neuronal injury after ischemia remains unclear. Normotensive rats received the angiotensin II type 1 receptor blocker, candesartan or only vehicle before induction of global cerebral ischemia. Approximately 30% of the hippocampal CA1 neurons survived in candesartan-treated animals, whereas only 2% of neurons survived in vehicle-treated animals. Superoxide production was significantly less in these vulnerable neurons in candesartan-treated animals than in vehicle-treated animals. Angiotensin II type 1 receptor may have an essential role in superoxide production and subsequent injury in vulnerable neurons after global cerebral ischemia.

Research Products

• [Journal Article] Limaprost alfadex improves myelopathy symptoms in patients with cervical spinal canal stenosis (2009)
  • Author(s): Sugawara T, Hirano Y, Higashiyama N, Mizoi K
  • Journal Title: Spine 34 Pages: 551-555
  • NAID: 10027239605
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages. (2009)
  • Author(s): Sugawara T, Itoh Y, Hirano Y, Higashiyama N, Mizoi K
  • Journal Title: Acta Neurochir 151 Pages: 303-309
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cases (2009)
  • Author(s): Sugawara T, Itoh Y, Hirano Y, Higashiyama N, Mizoi K
  • Journal Title: Acta Neurochir 151 Pages: 303-309
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Delayed matrix metalloproteinase inhibition reduces intracerebral hemo rrhage after embolic stroke in rats. (2008)
  • Author(s): Copin JC, Merlani P, Sugawara T, Chan PH, Gasche Y
  • Journal Title: Exp Neurol 213 Pages: 196-201
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats. (2008)
  • Author(s): Copin JC, Merlani P, Sugawara T, Chan PH, Gasche Y
  • Journal Title: Exp Neurol 213 Pages: 196-201
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Angiographically occult spinal dural arteriovenous fistula located using selective computed tomography angiography (2007)
  • Author(s): Sugawara T, Hirano Y, Itoh Y, Kinouchi H, Takahashi S, Mizoi K.
  • Journal Title: J Neurosurg Spine 7 Pages: 215-220
  • Peer Reviewed
• [Journal Article] Direct correlation between ischemic injury and extracellular glycine concentration in mice with genetically altered activities of the glycine cleavage multienzyme system (2007)
  • Author(s): Oda M, Kure S, Sugawara T, Yamaguchi S, Kojima K, Shinka T, Sato K, Narisawa A, Aoki Y, Matsubara Y, Omae T, Mizoi K, Kinouchi H.
  • Journal Title: Stroke 38 Pages: 2157-2164
  • Peer Reviewed
• [Journal Article] 酸化ストレスとRAS-脳-脳梗塞急性期病態への関与 (2006)
  • Author(s): 菅原 卓
  • Journal Title: Angiotensin Research 3.4 Pages: 261-266
• [Journal Article] Overexpression of SODI in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. (2006)
  • Author(s): Yu F, Sugawara T et al.
  • Journal Title: J Neurotrauma 23.5 Pages: 595-603
• [Presentation] NMDA receptor antagonist SM-31900 protects against delayed neuronal death and reduces neurogenesis induced by transient global ischemia in rats (2007)
  • Author(s): Sugawara T, Yamaguchi S, Omae T, Mizoi K, Kinouchi H
  • Organizer: Brain 07'& Brain PET 07'
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] NMDA receptor antagonist SM-31900 protects against delayed neuronal death and reduces neurogenesis induced by transient global ischemia in rats (2007)
  • Author(s): Sugawara T, Yamaguchi S, Omae T, Mizoi K
  • Organizer: Brain 07' and Brain PET 07'
  • Place of Presentation: Osaka
  • Year and Date: 2007-05-22
  • Description: 「研究成果報告書概要(欧文)」より