| Project/Area Number |
18591581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Niigata University |
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Principal Investigator |
OISHI Makoto Niigata University, Medical and Dental Hospital, Medical Assistant (00422593)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Masafumi Niigata University, Medical and Dental Hospital, Assistant Professor (00361907)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,920,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | functional imaging / epilepsy / cortical network / electrocorticpgraphy / magnetoencephalography |
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| Research Abstract |
The primary purpose of this study was to visualize "the epileptogenic network", which guide the appropriate cortical resection for medically intractable neocortical epilepsy. We investigated the cortical propagation and spreading of epileptic activities by combination of various electrophysiological analyses such as the new analytic method for MEG topographic analysis of ECoG, and cortico-cortical evoked potentials, in our surgical cases of neocortical epilepsy. We have also investigated consistencies among results obtained by multiple modalities and have attempted to establish the reliable preoperative evaluation method to improve surgical outcomes. We are still proceeding to correlate between the presurgical evaluations and postsurgical seizure outcomes. We achieved several conclusions so far. First, we found we can classify the epileptogenicity and intractability of patients' neocortical epilepsy by patterns of presurgical MEG results. Second, in patients with tumor lesion relating to epilepsy, we found we can demarcate the areas to be resected by topographic analysis of intraoperative ECoG data. Third, in patients with temporal lobe epilepsy, we confirm the existence of the epilepsy related network between the medial temporal structure and temporal neocortices by cortico-cortical evoked potentials. Our final strategy of this study was to combine our results of connections between cortices and results of the high-quality MR axonography, to visualize the patient's "epilepsy network". Due to the technical limitations, we could not have achieved at the goal in this respect. This study is still ongoing to improve such limitations and to establish the new diagnostic methods.
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