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Investigation of the mechanisms of epileptogenecity in cortical dysgenesis

Research Project

Project/Area Number 18591587
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyoto University

Principal Investigator

MIKUNI Nobuhiro  Kyoto University, Faculty of Medicine, Associate professor (60314217)

Co-Investigator(Kenkyū-buntansha) AMANO Shigeru  KYOTO UNIVERSITY, Faculty of Medicine, Professor (50111886)
IKEDA Akio  KYOTO UNIVERSITY, Faculty of Medicine, Associate Professor (90212761)
TOICHI Motomi  KYOTO UNIVERSITY, Faculty of Medicine, Professor (50303764)
MATSUMOTO Riki  KYOTO UNIVERSITY, Faculty of Medicine, Assistant Professor (00378754)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsepilepsy / cortical dysgenesis / brain function / 神経科学 / 医療・福祉
Research Abstract

We have studied the mechanisms underlying epileptogenesis in cortical dysplasia by using a rat model and a human specimen. The results have shown that excitatory postsynaptic NMDA receptors played a critical role of epilepsy associated with cortical dysplasia. To clarify the mechanisms of human epilepsy, we examined the total protein levels of both NR1 and calmodulin, as well as their coassembly in the human non- epileptogenic cortical areas compared to those in the epileptogenic cortical areas (ictal EEG seizure onset areas as determined by subdural grid electrode recordings). The coassembly of calmodulin and NMDAR1 was decreased in epileptogenic dysplastic cortex compared with normal appearing non- epileptogenic cortex, while there was no significant difference in the total protein levels of calmodulin or NMDAR1 between the two EEG groups. These results suggest that decreased calmodulin-NMDAR1 coassembly is a cellular mechanism that contributes to hyperexcitability in dysplastic cortical neurons and in focal seizure onsets. Reagarding the brain function, epileptic cortical dysplasia have language or motor function which could be compensated following resection. Furthermore, our results have shown that some of brain tumors were accompanied with epileptic cortical dysplasia.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (46 results)

All 2007 2006

All Journal Article (33 results) (of which Peer Reviewed: 18 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Deep brain stimulation of the posterior hypothalamus activates the his taminergic system to exert antiepileptic effect in rat pentylenetetrazol model2007

    • Author(s)
      Nishida N
    • Journal Title

      Exp Neurol 205

      Pages: 132-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Surgery of Cerebral Arteriovenous Malformations2007

    • Author(s)
      Hashimoto N
    • Journal Title

      Neurosurgery 61

      Pages: 375-389

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Fibers from the dorsal premotor cortex elicit motor-evoked potential in a cortical dysplasia2007

    • Author(s)
      Mikuni N
    • Journal Title

      Neuroimage 34

      Pages: 12-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison between motor evoked potential and fiber tracking for estimating pyramidal tracts near brain tumors2007

    • Author(s)
      Mikuni N
    • Journal Title

      J Neurosurg 106

      Pages: 128-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical impact of integrated functional neuronavigation and subcortical electrical stimulation to preserve motor function during the resection of brain tumors2007

    • Author(s)
      Mikuni N
    • Journal Title

      J Neurosurg 106

      Pages: 593-598

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical significance of preoperative fiber-tracking to preserve the affected pyramidal tracts during the resection of brain tumors in patients with preoperative motor weakness2007

    • Author(s)
      Mikuni N
    • Journal Title

      J Neurol Neurosurg Psychiatry 78

      Pages: 716-721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert antiepileptic effect in rat pentylenetetrazol model2007

    • Author(s)
      Nishida N
    • Journal Title

      Exp Neurol 205

      Pages: 132-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert2007

    • Author(s)
      Nishida N, Huang ZL, Mikuni N, Miura Y, Urade Y, Hashimoto N
    • Journal Title

      Exp Neurol 205

      Pages: 132-144

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibers from the dorsal premotor cortex elicit motor-evoked potential in a cortical dysplasia. Neuroimage2007

    • Author(s)
      Mikuni N, Oakada T, Taki J, et. al.
    • Journal Title

      Neuroimage 34

      Pages: 12-18

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bereitschaftspotentials recorded from the lateral part of the superior frontal gyms in humans2006

    • Author(s)
      Ohara S
    • Journal Title

      Neurosci Lett 399

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evidence for a wide distribution of negative motor areas in the perir olandic cortex2006

    • Author(s)
      Mikuni N
    • Journal Title

      Clin Neurophysiol 117

      Pages: 33-40

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A step-by-step resection guided by electrocorticography for non-malignant brain tumors associated with long-term intractable epilepsy2006

    • Author(s)
      Mikuni N
    • Journal Title

      Epilepsy Behav 8

      Pages: 560-564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Resection of cortical epileptogenecity2006

    • Author(s)
      Mikuni N
    • Journal Title

      Jpn J Neurosurg 15

      Pages: 195-202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Generators and temporal succession of giant somatosensory evoked potentials in cortical reflex myoclonus : Epicortical recording from sensorimotor cortex2006

    • Author(s)
      Hitomi T
    • Journal Title

      Clin Neurophysiol 117

      Pages: 1481-1486

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ipsilateral facial sensory and motor responses to basal fronto-temporal cortical stimulation : evidence suggesting direct activation of cranial nerves2006

    • Author(s)
      Begum T
    • Journal Title

      Epilepsy Res 71

      Pages: 216-222

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heterogeneous epileptogenicity and cortical function within malformations of cortical development : a case report2006

    • Author(s)
      Kinoshita M
    • Journal Title

      J Neurol Sci 251

      Pages: 129-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy2006

    • Author(s)
      Yamamoto J
    • Journal Title

      Seizure 15

      Pages: 520-527

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe epilepsy- preliminary results2006

    • Author(s)
      Mikuni N
    • Journal Title

      Epilepsia 47

      Pages: 1347-1353

    • NAID

      10019307665

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A minimally invasive transsulcal approach to the paracentral inner lesion2006

    • Author(s)
      Mikuni N
    • Journal Title

      Minim Invasive Neurosurg 49

      Pages: 291-295

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Bereitschaftspotentials recorded from the lateral part of the superior frontal gyrus in humans.2006

    • Author(s)
      Ohara S
    • Journal Title

      Neurosci Lett 399

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evidence for a wide distribution of negative motor areas in the perirolandic cortex.2006

    • Author(s)
      Mikuni N
    • Journal Title

      Clin Neurophysiol 117

      Pages: 33-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A step-by-step resection guided by electrocorticography for non-malignant brain tumors associated with long-term intractable epilepsy.2006

    • Author(s)
      Mikuni N
    • Journal Title

      Epilepsy Behav 8

      Pages: 560-564

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Resection of cortical epileptogenecity.2006

    • Author(s)
      Mikuni N, Hashimoto N
    • Journal Title

      Jpn J Neurosurg 15

      Pages: 195-202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Generators and temporal succession of giant somatosensory evoked potentials in cortical reflex myoclonus : Epicortical recording from sensorimotor cortex.2006

    • Author(s)
      Hitomi T
    • Journal Title

      Clin Neurophysiol 117

      Pages: 1481-1486

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ipsilateral facial sensory and motor responses to basal fronto-temporal cortical stimulation : evidence suggesting direct activation of cranial nerves.2006

    • Author(s)
      Begum T
    • Journal Title

      Epilepsy Res 71

      Pages: 216-222

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy.2006

    • Author(s)
      Yamamoto J
    • Journal Title

      Seizure 15

      Pages: 520-527

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe epilepsypreliminary results2006

    • Author(s)
      Mikuni N
    • Journal Title

      Epilepsia 47

      Pages: 1347-1353

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evidence for a wide distribution of negative motor areas in the perirolandic cortex.2006

    • Author(s)
      Mikuni N, Ohara S, Ikeda A, Hayashi N, Nishida N, Taki J
    • Journal Title

      Clin Neurophysiol 117・1

      Pages: 33-40

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A step-by-step resection guided by electrocorticography for non-malignant brain tumors associated with long-term2006

    • Author(s)
      Mikuni N, Ikeda A, Takahashi JA, Nozaki K, Miyamoto S, Taki W
    • Journal Title

      Epilepsy Behav 8・3

      Pages: 560-564

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Resection of cortical epileptogenecity2006

    • Author(s)
      Mikuni N, Hashimoto N
    • Journal Title

      脳神経外科ジャーナル 15・3

      Pages: 195-202

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal2006

    • Author(s)
      Mikuni N, Miyamoto S, Ikeda A, Satow I, Taki J, Takahashi J, Ohigashi Y, Hashimoto N
    • Journal Title

      Epilepsia 47・8

      Pages: 1347-1353

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heterogeneous epileptogenicity and cortical function within malformations of cortical development : a case2006

    • Author(s)
      Kinoshita M, Ikeda A, Taki J, Usui K, Matsumoto R, Mikui N, Takahashi JB, Fukuyama H, Hashimoto N, Takahashi R
    • Journal Title

      J Neurol Sci 251・1-2

      Pages: 129-133

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Low-frequency electric cortical stimulation decreases interictal and ictal activity in human epilepsy2006

    • Author(s)
      Yamamoto J, Ikeda A, Kinoshita M, Matsumoto R, Satow T, Takeshita K, Matsuhashi M, Mikuni N, Miyamoto S, Hashimoto N, Shibasaki H
    • Journal Title

      Seizure 15・7

      Pages: 520-527

    • Related Report
      2006 Annual Research Report
  • [Presentation] 脳機能と病態の理解に基づいた、てんかんの外科的治療2007

    • Author(s)
      三國信啓
    • Organizer
      三重脳神経外科集談会
    • Place of Presentation
      津
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Eloquent area の外科的治療法と治療予後の検証Eloquent areaに存在する病変の摘出と術後予後の検討2007

    • Author(s)
      三國信啓
    • Organizer
      第66回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 覚醒下手術の実際と意義2007

    • Author(s)
      三國信啓
    • Organizer
      浜松医科大学臨床神経カンファランス
    • Place of Presentation
      浜松
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] てんかん外科の基礎と応用2007

    • Author(s)
      三國信啓
    • Organizer
      第27回日本脳神経外科コングレス総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] てんかん外科における硬膜下電極2007

    • Author(s)
      三國 信啓
    • Organizer
      第27回日本脳神経外科コングレス総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腫瘍及びてんかんのコントロールを目指したLow grade gliomaの治療 -安全で確実な摘出のために-2007

    • Author(s)
      三國信啓
    • Organizer
      第16回脳神経外科手術と機器学会
    • Place of Presentation
      東京
    • Year and Date
      2007-04-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] awake surgeryの適応2007

    • Author(s)
      三國信啓
    • Organizer
      第49回関西脳神経外科懇話会
    • Place of Presentation
      大阪
    • Year and Date
      2007-02-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 内側側頭葉てんかんに対する手術手技-側頭下アプローチ2007

    • Author(s)
      三國信啓
    • Organizer
      第29回日本てんかん外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-01-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 術中モニタリングの限界と今後-脳電気刺激法を軸とした検査の中でのイメージング、覚醒下手術が持つ意義の検討2006

    • Author(s)
      三國信啓
    • Organizer
      第11回日本脳腫瘍の外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] トピックスレビュー : 内側側頭葉てんかんの手術-発作抑制と高次脳機能温存に関する術式の検討2006

    • Author(s)
      三國信啓
    • Organizer
      第52回日本脳神経外科学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2006-09-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] てんかん外科における現状と今後の課題2006

    • Author(s)
      三國信啓
    • Organizer
      第29回日本てんかん外科学会
    • Place of Presentation
      大宮
    • Year and Date
      2006-01-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 脳腫瘍の外科2007

    • Author(s)
      三國信啓
    • Total Pages
      5
    • Publisher
      メディカ出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 脳腫瘍の外科2007

    • Author(s)
      三國 信啓
    • Total Pages
      5
    • Publisher
      メディカ出版
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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