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Transplantation of primate embryonic stem cell-derived neural stem cell against brain ischemia

Research Project

Project/Area Number 18591588
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKyoto University

Principal Investigator

TAKAGI Yasushi  Kyoto University, Graduate School of Medicine, Lecturer (40312227)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsES cell / brain ischemia / regenerative therapy / primate / 神経幹細胞 / 移植
Research Abstract

It became possible that we can make neural stem cell from embryonic stem cells. Now we can stat to experimental transplantation aginst brain ischemia. We assessed the result of transplantation against mouse focal ischemaia model using monkey ES cells. We analyzed the survival of transplanted cells at 14 days and 28 days after ischemia. In addition, we analyzed matrix metalloproteinase expressions and tissue inhibitor of metalloproteinases after ischemis. We employed TIMP-1 and TIMP-2 knockout mice. Furthermore we analyzed the effect of heatshock protein110during brain ischemia.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (14 results)

All 2007 2006

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] Expression of hypoxia-inducing factor-1 alpha and endoglin in intimal hyperplasia of the middle cerebral artery of patients with Moyamoya disease.2007

    • Author(s)
      Takagi Y, et al.
    • Journal Title

      Neurosurgery 60

      Pages: 338-345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neuronal expression of Fas-associated death domain protein and caspase-8 in the perinidal parenchyma of cerebral arteriovenous malformations2007

    • Author(s)
      Takagi Y, et al.
    • Journal Title

      J Neurosurg 106

      Pages: 275-282

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cerebral aneurysm progression suppressed by blockage of endothelin Breceptor.2007

    • Author(s)
      Sadamasa N, et al.
    • Journal Title

      J Neurosurg 106

      Pages: 330-336

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] pression of hypoxia-inducing factor-1 alpha and endoglin in intimal hyperplasia of the middle cerebral artery of patients with Moyamoya disease.2007

    • Author(s)
      Takagi Y, Kikuta K, Nozaki K, Fujimoto M, Hayashi J, Imamura H, Hashimoto N.
    • Journal Title

      Neurosurgery. 60(2)

      Pages: 338-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuronal expression of Fas-associated death domain protein and caspase-8 in the perinidal parenchyma of cerebral arteriovenous malformations.2007

    • Author(s)
      Takagi Y, Kikuta K, Nozaki K, Fujimoto M, Hayashi J, Hashimoto N
    • Journal Title

      J Neurosurg. 106(2)

      Pages: 275-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cerebral aneurysm progression suppressed by blockage of endothelin B receptor.2007

    • Author(s)
      Sadamasa N, Nozaki K, Takagi Y, Moriwaki T, Kawanabe Y, Ishikawa M, Hashimoto N.
    • Journal Title

      J Neurosurg. 106(2)

      Pages: 330-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 脳梗塞に対する再生医療-現状と展望-2007

    • Author(s)
      高木 康志
    • Journal Title

      脳神経外科ジャーナル

      Pages: 481-489

    • NAID

      110006279434

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain2006

    • Author(s)
      Hayashi J, Takagi Y, Fukuda H, Imazato T, Nishimura M et al.
    • Journal Title

      J Cereb Blood Flow Metab 26(7)

      Pages: 906-914

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脳梗塞に対する細胞移植治療への期待-脳神経疾患への細胞移植治療の現状を含めて-2006

    • Author(s)
      高木康志
    • Journal Title

      脳循環代謝 18

      Pages: 104-109

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ES細胞を用いた脳梗塞治療2006

    • Author(s)
      高木康志
    • Journal Title

      分子血管病 5(4)

      Pages: 414-419

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脳梗塞に対するES細胞由来神経幹細胞の移植2006

    • Author(s)
      高木康志, 橋本信夫
    • Journal Title

      脳卒中 28

      Pages: 600-605

    • NAID

      10018686834

    • Related Report
      2006 Annual Research Report
  • [Presentation] 幹細胞移植とその臨床応用2007

    • Author(s)
      高木康志
    • Organizer
      第19回日本脳循環代謝学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transplantation of stem cells and clinical applications2007

    • Author(s)
      Yasushi Takagi
    • Organizer
      19^<th> annual meeting of Japanese society of cerebral blood flow and metabolism
    • Place of Presentation
      Morioka
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脳梗塞に対する再生医療2007

    • Author(s)
      高木 康志
    • Organizer
      日本脳循環代謝学会
    • Place of Presentation
      盛岡市
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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