| Budget Amount *help |
¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Research Abstract |
To validate the sensori-motor fiber somatotopy at semioval center with 3T-MRI based fiber tractography, we conducted the following study and obtained the results as followings.
1. In a total of 20 normal volunteers and patients, diffusion tensor imaging (DTI) was obtained by a 3T-MRI scanner. In the procedure, we standardized the MR parameters on DTI in the scanner, and appropriate parameters were set as slice thickness of 2.6mm, motion probing gradient of 25 axes and b-value of 2000. By putting 3 regions of interest (ROI) on the primary motor and sensory cortices, we could delineate motor and sensory fibers innervating to upper extremity, trunk and lower extremity separately. Fiber tractography delineating three major bundles separately were exported as DICOM images and utilized on surgical nerro-navigator.
2. We compared those anatomical ROIs with functional cortical structure obtained by functional MRI and magnetoencephalography (MEG) in 15 patients. In fourteen patients, those anatomically defined ROIs for fiber tractography were compatible with functional data. We observed one patient with diffuse astrocytoma arising from primary motor area, in whom fractional center was thought to have slightly moved from anatomically defined center. In most of cases, we can define the ROIs anatomically for fiber tractography, however, in some instances like slowly growing tumors, we need to use functional data from fMRI or MEG to set ROIs for fiber tractography.
3.In 5 patients who underwent eloquent surgery for the lesions close to semioval center, validation study was conducted by comparing 3T-MRI fiber tractography on navigational system with electrophysiological study by sensory and motor evoked potentials (SEP and MEP). In 4 patients in whom SEP and MEP were trustable, sensori-motor fiber somatotopy obtained by fiber tractography was successfully validated.
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