• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation the roles of LPA producing enzyme ATX in the invasion of glioma

Research Project

Project/Area Number 18591609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSaitama Medical University (2007)
Teikyo University (2006)

Principal Investigator

FUJIMAKI Takamitsu  Saitama Medical University, Faculty of Medicine, Professor (80251255)

Co-Investigator(Kenkyū-buntansha) MOCHIZUKI Toshihiro  Teikyo University, Faculty of Medicine, Lecturer (30302706)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,520,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsglioma / invasion / LPA / autotaxin / Autotaxin / Glioma
Research Abstract

Gliomas are malignant brain tumors. The 2-year survival of most malignant form of glioma, glioblastoma, is less than 20%. These tumors are difficult to treat because of the invasiveness of the tumor cells.
Autotaxin (ATX) is a phosphodiesterase and a potential cell motility-stimulating factor. ATX is identical to lysophospholipase D, which produces lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). In this study, we found that ATX transfected mouse gliomas are more motile and infiltrative in vitro. Moreover our result showed that mRNA of ATX is highly expressed in higher grade gliomas whereas that expression is lower in low grade gliomas or other benign brain tumors. A patient with low grade glioma who had high expression of ATX recurred early to show the malignant nature of the tumor.
These results suggest that the ATX contributes to the invasiveness of glioma cells and is correlated with the malignant characteristics of glioma.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (12 results)

All 2007 2006

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocyatoma2007

    • Author(s)
      Fujimaki T
    • Journal Title

      Wourld J Surgical Oncol 89

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocyatoma2007

    • Author(s)
      Fujimaki, T
    • Journal Title

      Wourld J Surgical Oncol 89

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid2006

    • Author(s)
      Kishi Y
    • Journal Title

      J Biol Chem 281

      Pages: 17492-17500

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Congenital gemistocytic astrocytoma in a fetus2006

    • Author(s)
      Nozaki M
    • Journal Title

      Childs Nerv Syst 22

      Pages: 168-171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid2006

    • Author(s)
      Kishi, Y
    • Journal Title

      J Biol Chem 281

      Pages: 17492-500

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Congenital gemistocytic astrocytoma in a fetus2006

    • Author(s)
      Nozaki, M
    • Journal Title

      Childs Nery Syst 22

      Pages: 168-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.2006

    • Author(s)
      Kishi Y, Fujimaki T, Arai H, et al.
    • Journal Title

      J Biol Chem 281.25

      Pages: 17492-17492

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 神経膠腫に対するTemozolomide2006

    • Author(s)
      藤巻 高光
    • Journal Title

      Medibal Briefs in Brain and Nerve 15.1

      Pages: 8-8

    • Related Report
      2006 Annual Research Report
  • [Presentation] Interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent malignant gliomas:a single institutional phase I-II trial2007

    • Author(s)
      Fujimaki T
    • Organizer
      The 5^<th> Meeting of the Asian Society for Neuro-Oncology
    • Place of Presentation
      Istanbur
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Autotaxin is overexpressed in glioma and contributes to cell morility of glioblastoma cells2006

    • Author(s)
      Fujimaki T
    • Organizer
      The 11th International Congress of Metastasis Research Society
    • Place of Presentation
      Tokushima
    • Year and Date
      2006-09-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Autotaxin is overexpressed in glioma and contributes to cemotility of glioblastoma cells2006

    • Author(s)
      Fujimaki, T
    • Organizer
      The 11th International Congress of Metastasi Research Society
    • Place of Presentation
      Tokushimm JAPAN
    • Year and Date
      2006-09-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 脳神経外科専門医に聞く最新の臨床/Low grade glioma に放射線照射を行なうべきか(分担執筆)2006

    • Author(s)
      藤巻 高光
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi