| Project/Area Number |
18591616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Meiji College of Oriental Medicine |
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Principal Investigator |
TANAKA Chuzo Meiji College of Oriental Medicine, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (80163541)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Toshihiro MEIJI UNIVERSITY OF ORIENTAL MEDICINE, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (80218700)
UMEDA Masahoro MEIJI UNIVERSITY OF ORIENTAL MEDICINE, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (60223608)
AOKI Ichio National Institute of Radiological Sciences, Biophysics Group, Molecular Imaging Center, MR Molecular Imaging Team, Team Leader (10319519)
WTANABE Yasuharu MEIJI UNIVERSITY OF ORIENTAL MEDICINE, SCHOOL OF HEALTH SCIENCES AND MEDICAL CARE, PROFESSOR (90454537)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,950,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | manganese enhanced MRI / AIM-MRI / molecular imaging / neural regeneration / cerebral infarction / gliosis / transient cerebral ischemia / hippocampus / MEMRI / 一過性脳虚血 / アポトーシス / グリオーシス / マンガン造影 / fMRI / 個体差 / 3次元感覚マップ |
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| Research Abstract |
In this study, molecular MR imaging has been developed using manganese enhanced brain imaging. Activity-Induced Manganese-dependent (AIM) MRI was introduced in fMRI as method independent of hemodynamic changes. 1) Though systemic administration of MnC1 always showed enhanced hypocampal structures such as CA1, CA2, and dentate gyrus. We could not show the decreased signal change in CA1 layer at transient cerebral ischemia using rat cardiac arrest model. Our study has performed using a 7 tesla MR apparatus to improve the signal noise ratio of MR images. 2) From histological examination, we could obtained apoptotic changes in CA1 cells in acute stage and increased glial cells in chronic stage. 2) Using this model, a water maze test could not show the behavior difference between transient ischemia rats and control rats except very acute stage in cerebral ischemia. 3) Though systemic administration of MnC12 always showed enhanced spinal cord, in the case of rat spinal injury model, contused spinal cord has not been enhanced in any stages. This model was useful to analyze acute spinal cord injury and its recovery stage.
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