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Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 in nerve regeneration

Research Project

Project/Area Number 18591629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAGANO Akira  Hamamatsu University School of Medicine, 医学部, 教授 (50272547)

Co-Investigator(Kenkyū-buntansha) SAWADA Tomokazu  浜松医科大学, 医学部・附属病院, 助教 (10397375)
SANO Michio  浜松医科大学, 医学部, 助手 (50313945)
OMURA Takao  浜松医科大学, 医学部・附属病院, 助教 (70402295)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords脳・神経 / 再生医学 / 神経再生 / Waller変性 / サイトカイン / 血液-神経関門
Research Abstract

ラット坐骨神経圧挫モデルを用いて、末梢神経におけるWaller変性と引き続きおこる神経再生時におけるTNFα、IL-10の経時的・部位的変化の検討を行った。血液-神経関門(BNB)の検討とあわせて考えると、免疫染色におけるTNFα陽性細胞数の変化とBNBの変化が同時期、同部位に起きており、TNFαがBNBの変化に深く関わっていることが考えられた。また、IL10の変化はTNFαの変化に先立っておきており、IL-10はTNFαの変化の鍵になっていることが示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (4 results)

All 2007 2006 2005

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistry2007

    • Author(s)
      Sawada T, Sano M, Omura T, Omura K, Hasegawa T, Funahashi S, Nagano A.
    • Journal Title

      Neuroscience Letters 417

      Pages: 55-60

    • Related Report
      2008 Final Research Report
  • [Journal Article] Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistry2007

    • Author(s)
      Sawada T, Sano M, Omura T, Omura K, Hasegawa T, Funahashi S, Nagano A
    • Journal Title

      Neuroscience Letters 417

      Pages: 55-60

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 末梢神経再生におけるTNFαの変化の検討2006

    • Author(s)
      澤田智一他
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎市
    • Year and Date
      2006-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 末梢神経損傷後に遊走する炎症性細胞とIL10の検討2005

    • Author(s)
      澤田智一他
    • Organizer
      第20回日本整形外科学会基礎学術集会
    • Place of Presentation
      伊勢市
    • Year and Date
      2005-10-20
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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