• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Transplantation of opioid-gene-transferred autologous macrophage for the treatment of neurogemc pain

Research Project

Project/Area Number 18591635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionEhime University

Principal Investigator

YAMAMOTO Haruyasu  Ehime University, Graduate School of Medicine, Professor (10092446)

Co-Investigator(Kenkyū-buntansha) OGATA Tadanori  Ehime University, Graduate School of Medicine, Senior Assistant Professor (30291503)
森野 忠夫  愛媛大学, 医学部附属病院, 講師 (20380248)
NAKANO Yoko  Ehime University, Graduate School of Medicine, Senior Assistant Professor
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥2,760,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsPain / macrophage / gene-transfer / electroporation / Sciatic nerve / proenkepharin / pain / sciatic nerve
Research Abstract

To develop a novel analgesic treatment for neuropathic pain, opioid gene-transferred autologous macrophages were injected via lumbar puncture into the neuropathic pain model rats. Chronic constriction was produced in the left side by ligation using polyglucolic acid strings. These animals showed apparent hyperalgesia and allodynia in the left frt. Injection of opioid gene-transferred autologous macrophages effectively counteract the pain sensation induced by the chronic constriction. The opioid gene-transferred macrophages migrated into the gray matter in the lumbar spinal cord and showed proenkephalin mRNA. This method may be a useful technique for the treatment of several neuropathic pain.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2021-11-05  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi