| Project/Area Number |
18591637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAYA Mitsunori Sapporo Medical University, MEDICAL SCHOOL, INSTRUCTOR (10398315)
|
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| Co-Investigator(Kenkyū-buntansha) |
WADA Takuro SAPPORO MEDICAL UNIVERSITY, MEDICAL SCHOOL, ASSOCIATE PROFESSOR (00244369)
YAMASHITA Toshihiko SAPPORO MEDICAL UNIVERSITY, MEDICAL SCHOOL, PROFESSOR (70244366)
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| Project Period (FY) |
2006 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Osteosarcoma / Pulmonary Metastasis / Anti-angingenic Therapy / Dormant / 肺移転 |
|---|
| Research Abstract |
We have evaluated the effect of anti-angiogenic therapy using endostatin on postoperative progression of pulmonary metastasis in osteosarcoma. Infection of a recombinant adonovirus which encodes endostatin cDNA after primary tumor removal suppressed the postoperative upregulation of systemic angiogenic activity and kept micrometastases dormant, which resulted in the prevention of progression of pulmonary metastasis. Our results indicate that anti-angiogenic therapy using endostatin has the potential to prevent postoperative progression of pulmonary metastasis in osteosarcoma. Although this therapeutic strategy cannot provide a cure for osteosarcoma, it should enable osteosarcoma patients to coexist with dormant pulmonary metastasis, and lead to the improvement of their prognosis.
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