| Project/Area Number |
18591658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Niigata University |
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Principal Investigator |
OGOSE Akira Niigata University, Institute of Meclicine and Dentistry, Associate Professor (80323963)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Bone formation / Calcium phosphate / Bone marrow cells / Micropore / Surface structure / 再生医療 / 骨再生 / マイクロポアー |
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| Research Abstract |
We did three experiments for developing new bone graft technique
1) Histological assessment of bone formation of be-ta tricalcium phosphate with bone marrow grafted in rat subcutaneous tissue.
2) Histological and histomorphometrical assenment of bone formation of beta-tricalcium phosphate with or without micropore in dog dorsal mscle
3) Analyses of bone formation of beta-tricalcium phosphate with human bone like substance in SCID mouse
These experiments resulted
Osteoclastogensis is found before bone formation in calcium phosphate in rat subcutaneous bone formation model.
Micropore structure stimulated bone formation in calcium phosphate with or without bone marrow
Tricalcium phosphate with bone like substance produced new bone formation in SCD mouse model
These results indicated that combination of calcium phosphate, bone marrow cell and bone like substance is reasonable new technique for bone grafting.
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