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Effect of hyperbaric oxygen therapy on the ligament healing process

Research Project

Project/Area Number 18591674
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionDokkyo Medical University

Principal Investigator

TAMAI Kazuya  Dokkyo Medical University, faculty of medicine, Professor (40137831)

Co-Investigator(Kenkyū-buntansha) HOSHIKAWA Atsuto  Dokkyo Medical University, faculty of medicine, lecturer (50383021)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,860,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsHyperbaric oxygen therapy / Type I collagen / ligament injury / healing process / 靭帯治癒
Research Abstract

Hyperbaric oxygen therapy (HBO) has been known as a first option of treatment for decompression sickness, air embolism, carbon monoxide poisoning. Recently, HBO also has been applied for sports-related injuries, hoping it could promote the healing process of the soft tissue injuries such as a ligament injury. However, the effect on the soft tissue injuries was considered controversial in several clinical studies. Probably, the conflicting result was caused by the inconsistent setting of HBO such as the loading pressure, the loading time, the duration and interval of treatment. Therefore, basic research on HBO seems to be necessary to clarify the effect of HBO on the soft tissue injury. Previously, we reported that HBO for 4weeks promoted the healing process of the medial collateral ligament (MCL) of rats. The expression of Type I procollagen gene in the healing scar tissues increased in in situ hybridization and the tensile property of the healing ligaments of HBO group was greater tha … More n that of control group. The aim of this study is to examine the optimal timing of HBO to achieve the maximum of efficacy in the ligament healing.
In this study, HBO was administered under same protocol consisting of administering 100% oxygen at 2.5 atmospheres absolute for 2 hours 5 days per week. As the animal model of ligament injury, we used the gap model of MCL in rats, in which a 3-mm wide segment of the mid-substance of the MCL was resected. In the study on the fracture healing, the shaft of the femur in rats was cut using the cutter for plaster and fixed using intramedullary nailing of Kirchner wire. Real-time PCR revealed the increasing amount of expression of type I procollagen mRNA in HBO group as compared with control group ; this was especially apparent in early period after the operation. When the initiation of HBO was delayed for 1 week, the extent of expression of type I procollagen mRNA was almost equal to that of control group. In the study in vitro, when fibroblasts derived from human anterior cruciate ligaments was cultured with administering HBO, remarkable proliferation of fibroblasts was found rather than the increasing expression of type I procollagen mRNA. These results indicated that HBO should administer immediately after injury and extending over a long period seemed not to have very critical meaning. We speculated that administering HBO favorably affected the ligament healing through a sufficient supply of mesenchymal cells participating in the proliferation period of the healing process. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (8 results)

All 2008 2007 Other

All Journal Article (4 results) Presentation (4 results)

  • [Journal Article] 高圧酸素療法が損傷軟部組織治癒に与える温熱、血流的効果に関する研究2007

    • Author(s)
      星川 淳人
    • Journal Title

      Biomedical Thermology 27巻

      Pages: 32-32

    • NAID

      10019728986

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Thermal and hemodynamic effect of hyperbaric oxygen on the ligament healing process2007

    • Author(s)
      Hoshikawa, Atsuto
    • Journal Title

      Biomedical Thermology 27

      Pages: 32-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 高圧酸素療法渉損傷軟部組織治癒に与える温熱・血流的勧果に関する研究2007

    • Author(s)
      星川 淳人
    • Journal Title

      Biomedical Thermology 27巻

      Pages: 32-32

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 高圧酸素療法が損傷軟部組織治癒に与える温熱・血流的効果に関する研究2007

    • Author(s)
      星川淳人, 玉井和哉
    • Journal Title

      Biomedical Thermology 27.1(印刷中)

    • NAID

      10019728986

    • Related Report
      2006 Annual Research Report
  • [Presentation] 靭帯治癒過程における高気圧酸素負荷の至適時期2008

    • Author(s)
      阿久津 みわ
    • Organizer
      日本整形外科基礎学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-10-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 骨折治癒過程における高気圧酸素療法の効果2008

    • Author(s)
      高井 盛光
    • Organizer
      日本整形外科基礎学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2008-10-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Optimal stage of hyperbaric oxygen loading on ligament healing

    • Author(s)
      Akutsu, Miwa
    • Organizer
      The 23rd Annual Research Meeting of the Japanese Orthopaedic Association
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of hyperbaric oxygen on fracture healing process

    • Author(s)
      Takai, Morimitsu
    • Organizer
      The 23rd Annual Research Meeting of the Japanese Orthopaedic Association
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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