Evaluation of articnlar cartilage made from mesenchymal stemcell drived from adipose using MRI

• Project/Area Number: 18591679
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Teikyo University
• Principal Investigator: YAMASHITA Takeshi Teikyo University, 医学部, 講師 (80407915)
• Co-Investigator(Kenkyū-buntansha): 和田 佑一 帝京大学, 医学部, 教授 (10282485) ; 中川 晃一 千葉大学, 医学部附属病院, 助教 (30400823)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,130,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥630,000); Fiscal Year 2009: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 軟骨 / MRI / 幹細胞 / 脂肪 / 関節軟骨 / 関節病学 / 骨軟骨代謝学

Research Abstract

New methods to treat the articular cartilage defects using adipose tissue in vitro were examined in the field of cartilage tissue engineering that already clinical trials had been started. Delayed gadolinium enhanced MRI of cartilage to evaluate the articular cartilage was efficient in clinical cases. New phenomenon that extracellular matrix could repair reversibly after an operation was observed.

Research Products

• [Presentation] 軟骨造影MRIを用いた前十字靱帯再建術後の関節軟骨評価 (2009)
  • Author(s): 山下剛司
  • Organizer: 日本関節鏡学会(JOSKAS)
  • Place of Presentation: 札幌
  • Year and Date: 2009-06-25
• [Presentation] Evaluation of the articular cartilage using dGEMRIC after HTO (2009)
  • Author(s): T. Yamashita
  • Organizer: 日仏整形外科学会
  • Place of Presentation: 沖縄
  • Year and Date: 2009-05-29
• [Presentation] 軟骨造影MRIを用いた変形性膝関節症の評価 (2009)
  • Author(s): 山下剛司
  • Organizer: 日本関節症研究会
  • Place of Presentation: 横浜
  • Year and Date: 2009-05-23
• [Presentation] Evaluation of ankle cartilage injury using dGEMRIC technique (2009)
  • Author(s): T. Yamashita
  • Organizer: 国際関節症学会(ISAKOS)
  • Place of Presentation: 大阪
  • Year and Date: 2009-04-04
• [Presentation] Time course evaluation of articular cartilage after high tibial osteotomy using dGEMRIC (2008)
  • Author(s): 山下剛司
  • Organizer: アジア太平洋膝関節学会
  • Place of Presentation: インドネシア
  • Year and Date: 2008-10-29
• [Presentation] Evaluation of articular cartilage after high tibial osteotomy using dGEMRIC (2008)
  • Author(s): 山下剛司
  • Organizer: 国際関節症学会
  • Place of Presentation: イタリア
  • Year and Date: 2008-09-18
• [Presentation] Time course evaluation of articular cartilage of the ankle using dGEMRIC (2008)
  • Author(s): 山下剛司
  • Organizer: 国際整形外科学会
  • Place of Presentation: 香港
  • Year and Date: 2008-08-24
• [Presentation] Evaluation of articular cartilage after ATFL reconstruction using dGEMRIC (2008)
  • Author(s): 山下剛司
  • Organizer: ヨーロッパスポーツ整形外科学会
  • Place of Presentation: ポルトガル
  • Year and Date: 2008-05-21
• [Presentation] Evaluation of articular cartilage after ATFL reconstruction us ing dGEMRIC (2008)
  • Author(s): 山下剛司
  • Organizer: ヨーロッパスポーツ整形外科学会
  • Place of Presentation: ポルトガル
  • Year and Date: 2008-05-21
• [Presentation] 遅延相軟骨造影MRIを用いた足関節靭帯再建術における軟骨細胞外基質の評価 (2008)
  • Author(s): 山下 剛司
  • Organizer: 日本軟骨代謝学会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-21
• [Presentation] 遅延相軟骨造影MRIを用いた高位脛骨骨切り術の関節軟骨評価 (2008)
  • Author(s): 山下 剛司
  • Organizer: 日本人工関節学会
  • Place of Presentation: 沖縄
  • Year and Date: 2008-02-29