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The neuronal toxicity of general anesthetics on the developing rat brain

Research Project

Project/Area Number 18591683
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHokkaido University

Principal Investigator

MORIMOTO Yuji  Hokkaido University, Graduate School of Medicine, Professor (00250457)

Co-Investigator(Kenkyū-buntansha) TACHIBANA Kaori  Hokkaido University, Hokkaido Univ. Hospital, Medical Doctor (50374468)
YOSHIOKA Mitsuhiro  Hokkaido University, Graduate School of Medicine, Professor (40182729)
TSURUGA Kenkichi  Hokkaido University, Hokkaido Univ. Hospital, Medical Doctor (50399896)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,950,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsAnesthesia / Neurotoxicity
Research Abstract

It was recently shown that exposure of commonly used general anesthetics to the developing rat brain during the peak of synaptogenesis can trigger widespread apoptotic neurodegeneration in the brain, especially in the hippocampus. This can cause the persistent learning/memory deficits later on life. This study examined whether pentobarbital, an anesthetic with GABAergic property, administered to neonate rats, can trigger the behavioral and electrophysiological deficits occur later in adulthood. Rats administered pentobarbital (10 and 20 mg/kg, i.p.) on the 7th day after birth (7PD) displayed suppressed the hippocampal long-term potentiation (LTP) at 10-12 weeks old. Paired-pulse facilitation was augmented by pentobarbital, suggesting the presynaptic depression in the hippocampus. The behavioral exploration, tested by the open field test, showed the tendency of suppression. Exploration in the open-field test has shown to correlate to the hippocampal function, i.e. spatial memory and learning. These data suggest that administration of pentobarbital during a critical stage of brain development may result in functional deficits of hippocampus in adulthood. On the other hand, blood gas analysis during the pentobarbital anesthesia at 7PD induced the critical hypoxia and/or systemic acidosis via the respiratory depression. Given that neonatal hypoxia and/or systemic acidosis can cause the hippocampal dysfunction later on life, we have to take that bias into consideration when discussing the functional deficits induced by pentobarbital during a critical stage of neonatal brain development.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (7 results)

All 2007

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo.2007

    • Author(s)
      Kaori Tachibana, Koichi Takita, Toshikazu Hashimoto, Machiko Matsumoto, Mitsuhiro Yoshioka and Yuji Morimoto
    • Journal Title

      Anesthesia and Analgesia 105(4)

      Pages: 1006-1011

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo2007

    • Author(s)
      Kaori Tachibana, Koichi Takita, Toshikazu Hashimoto, Machiko Matsumoto, Mitsuhiro Yoshioka and Yuji Morimoto
    • Journal Title

      Anesthesia and Analgesia 105(4)

      Pages: 1006-1011

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Isoflurane bidirectionally modulates the paired-pulse responses in the rat hippocampal CA1 field in vivo2007

    • Author(s)
      Kaori Tachibana
    • Journal Title

      Anesthesia and Analgesia 105

      Pages: 1006-1011

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Isoflurane bidirectionally modulates the hippocampal paired-pulse responses in vivo.2007

    • Author(s)
      Kaori Tachibana and Yuji Morimoto
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Isoflurane bidirectionally modulates the hippocampal paired-pulse responses in vivo.2007

    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-09-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 低濃度イソフルランはin vivoラット海馬CA1領域で短期シナプス可塑性を増強する2007

    • Author(s)
      橘 かおり, 橋本 聡一, 森本 裕二
    • Organizer
      第54回日本麻酔科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Low concentration of isoflurane induces paired-pulse facilitation in the hippocampal CA1 field: an in vivo study.2007

    • Organizer
      The 54th Annual meeting of Japanese Society of Anesthesiologists.
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2007-03-31
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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