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Approach to the genetic therapy of neuropathic pain with the lentivirus vector

Research Project

Project/Area Number 18591686
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTohoku University

Principal Investigator

KATO Masato  Tohoku University, Tohoku Univ. Graduate Sc., of Med., PROFESSOR (50169520)

Co-Investigator(Kenkyū-buntansha) SATOH Daizoh  Tohoku Univ. Graduate Sch., Of Med., 大学院・医学系研究科, Associate Professor (30205934)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordsvector / neuropathic pain / gene pain therapy / 脳・神経 / 遺伝子 / ウィルス
Research Abstract

Na 1.8 is an isoform of voltage-gated sodium channel implicated in the pathogenesis of inflammatory and neuropathic pain. Previously, our collaborative researchers described a series of results in which they blocked production of NAV 1.8 utilizing a strategy so called RNA interference. They used a lentivirus that is taken up by cells and expresses the small hairpin RNA to block the production of the voltage-gated sodium channel subtype.
Present research have tried to investigate the above mentioned effect of the off target effect of the RNA interference of NaV 1.8 mRNA on the rat chronic pain model. However, there was a legal issues concerning the transport of the lentivirus vector from the United States to Japan. Therefore, we could not yet harvest enough data to submit the results to international journals, particularly on this specific issue

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (11 results)

All 2008 2007 2006 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (2 results)

  • [Journal Article] 小児の硬膜外麻酔実施状況:全国大学病院アンケート調査2008

    • Author(s)
      蔵谷紀文、加藤正人
    • Journal Title

      麻酔 57

      Pages: 230-237

    • NAID

      40015847449

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Awake craniotomy麻酔管理の現状2008

    • Author(s)
      佐藤清貴、加藤正人、坂部武史ほか
    • Journal Title

      麻酔 57

      Pages: 492-496

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pediatric epidural catheterization in Japan: A postal survey of current Status in university hospitals2008

    • Author(s)
      NORIFUM KURATANI
    • Journal Title

      MASUI 57

      Pages: 230-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The present state of anesthetic management for awake craniotomy in Japan2008

    • Author(s)
      KTYOTAKASATO
    • Journal Title

      MASUI 57: (4)

      Pages: 492-496

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 薬物動態における他の麻薬との比較と特徴2007

    • Author(s)
      加藤正人、佐藤大三、岡田吉史ほか
    • Journal Title

      麻酔 56

      Pages: 1281-1286

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pharmacodynamics and pharmacokinetics of remifentanil: Overview and comparison with other opioids2007

    • Author(s)
      MASATO KATO
    • Journal Title

      MASUI 56: (11)

      Pages: 1281-1286

    • NAID

      40015700238

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 麻酔管理と長期予後2006

    • Author(s)
      加藤 正人, 黒澤 伸
    • Journal Title

      臨床麻酔 30・11

      Pages: 1707-1707

    • Related Report
      2006 Annual Research Report
  • [Presentation] シンポジウム:吸入麻酔薬との併用によるレミフェンタニルの使用2007

    • Author(s)
      加藤 正人、佐藤 大三ほか
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Balanced general anesthesia with remifentanil and inhalational anesthetics

    • Author(s)
      MASATO KATO
    • Organizer
      The 54^<th> Annual Meeting of the Japanese Society of Anesthesiologists
    • Place of Presentation
      Sapporo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] すぐ役に立つレミフェンタニル(アルチバ)の使用法:腹部外科手術2007

    • Author(s)
      加藤 正人、佐藤 大三
    • Total Pages
      113
    • Publisher
      株式会社 ライフメディコム
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] すぐ役に立つレミフェンタニル(アルチバ)の使用法:腹部外科手術2007

    • Author(s)
      加藤 正人、佐藤 大三
    • Publisher
      株式会社 ラィフメディコム
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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