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A novel biomarker of oxidative stress : Exhaled CO concentration

Research Project

Project/Area Number 18591705
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOkayama University

Principal Investigator

MATSUMI Masaki  Okayama University, 医学部・歯学部附属病院, 准教授 (70219476)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Tooru  岡山大学, 医学部・歯学部附属病院, 講師 (40252952)
MORIMATU Hiroshi  岡山大学, 医学部・歯学部附属病院, 助教 (30379797)
MORITA Kiyoshi  岡山大学, 大学院・医歯薬学総合研究科, 教授 (40108171)
SHIMIZU Hiroko  岡山大学, 医学部, 客員研究員 (80423284)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,090,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords麻酔学 / 周術期管理学 / 蘇生学 / MODS / 酸化ストレス / ヘムオキシゲナーゼ / ヘム / ビリルビン / 一酸化炭素 / 連続呼気ガス測定 / SIRS / 呼気一酸化炭素 / COヘモグロビン
Research Abstract

医学の発達により心臓や肝臓などに対する侵襲の大きな手術が行われるようになってきた。しかし、手術自体が成功しても、その後、呼吸不全・腎不全などの多臓器不全に陥って死亡する症例が後を絶たない。本研究では、ストレスにより細胞内に誘導される蛋白Heme Oxygenase-1 (HO-1)の酵素反応産物である一酸化炭素(CO)が呼気に排出され、これが臓器不全の指標となり治療に応用できる可能性を示した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (21 results)

All 2009 2008 2007 2006 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock2009

    • Author(s)
      Takahashi T, Shimizu H, Morimatsu H, Maeshima K, Inoue K, Akagi R, Matsumi M, Katayama H, Morita K. Heme
    • Journal Title

      J Clin Biochem Nutr 44

      Pages: 28-40

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemin treatment abrogates monocrotaline-induced pulmonary hypertension2008

    • Author(s)
      Shimzu K, Takahashi T, Iwasaki T, Shimizu H, Inoue K, Morimatsu H, Omori E, Matsumi M, Akagi R, Morita K
    • Journal Title

      Med Chem 4

      Pages: 572-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased exhaled carbon monoxide concentration during living donor liver transplantation2008

    • Author(s)
      Matsusaki T, Morimatsu H, Takahashi T, Matsumi M, Sato K, Kaku R, Sato T,Takahito Yagi, Tanaka N, Morita K
    • Journal Title

      Int J Mol Med 21

      Pages: 75-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体肝移植後のfast-track管理2008

    • Author(s)
      松三昌樹
    • Journal Title

      日集中医誌 15

      Pages: 350-1

    • NAID

      10024840998

    • Related Report
      2008 Final Research Report
  • [Journal Article] A 27-year-old man who died of acute liver failure probably due to trichloroethylene abuse2008

    • Author(s)
      Takaki A, Suzuki H, Iwasaki Y, Takigawa T, Ogino K, Matsuda H, Yagi T, Hanazaki M, Nakatsuka H, Katayama H, Matsumi M, Shoji B, Terada R, Kobashi H, Sakaguchi K
    • Journal Title

      J Gastroenterol 43

      Pages: 239-42

    • NAID

      10021268046

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体肝移植術中呼気一酸化炭素濃度の動態とその意義について2008

    • Author(s)
      松崎孝、森松博史、高橋徹、林真雄、佐藤哲史、佐藤健治、清水裕子、松三昌樹、森田潔
    • Journal Title

      日本Shock学会雑誌 23

      Pages: 85-89

    • NAID

      10024300637

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hemin treatment abrogates monocrotaline-induced pulmonary hypertension2008

    • Author(s)
      Shimzu K, Takahashi T, Matsumi M, et al.
    • Journal Title

      Medicial Chemistry 4

      Pages: 572-576

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased exhaled carbon monoxide concentration during living donor liver transplantation2008

    • Author(s)
      Matsusaki T, Morimatsu H, Takahashi T, Matsumi M, et al.
    • Journal Title

      International Journal of Molecular Medicine 21

      Pages: 75-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット出血性ショック後急性肺傷害に対するウリナスタチンの治療効果2007

    • Author(s)
      井上一由, 高橋 徹, 井戸佳奈, 清水裕子, 森松博史, 前島亨一朗, 松三昌樹, 片山 浩,森田 潔
    • Journal Title

      日本Shock学会雑誌 22

      Pages: 96-99

    • NAID

      10024300584

    • Related Report
      2008 Final Research Report
  • [Journal Article] 全身性炎症反応における呼気中一酸化炭素(CO)濃度の上昇2007

    • Author(s)
      高橋 徹、松三昌樹、他7名
    • Journal Title

      エンドトキシン研究 10

      Pages: 65-68

    • Related Report
      2007 Annual Research Report
  • [Journal Article] IIcmc Arginate Pretreatment Attenuates PuImonary NF-κB and AP-1 Activation Induced by Hemorrhagic Shock via Heme Oxygenase-1 Induction2006

    • Author(s)
      T.Sasaki, T.Takahashi, et al.
    • Journal Title

      Medicinal Chemistry 2

      Pages: 271-274

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 敗血症性多臓器不全におけるストレス淡白 : ヘムオキシゲナーゼー1の発現とその意義2006

    • Author(s)
      高橋 徹, 松三昌樹, 森田 潔他
    • Journal Title

      エンドトキシン研究 9

      Pages: 70-75

    • Related Report
      2006 Annual Research Report
  • [Presentation] HO-1は出血性ショックによる自然免疫系の活性化を抑制し腸管を保護する2008

    • Author(s)
      松三昌樹
    • Organizer
      日本エンドトキシン研究会
    • Place of Presentation
      仙台市 艮陵会館
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Peak Exhaled Carbon Monoxide Concentration and Hyperbilirubinemia after Liver Transplantation2007

    • Author(s)
      Matsumi M
    • Organizer
      American Society of Anesthesiologists 2007 Annual Meeting
    • Place of Presentation
      Francisco, CA, USA
    • Year and Date
      2007-10-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Peak Exhaled Carbon Monoxide Concentration and Hyperbilirubinemia after Liver Transplantation2007

    • Author(s)
      Matsusaki, T., Matsumi, M., Takahashi, T., et. al.
    • Organizer
      Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      San francisco, USA
    • Year and Date
      2007-10-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Increased exhaled carbon monoxide concentration during living donor liver transplantation2007

    • Author(s)
      Matsumi M
    • Organizer
      The 5th International Congress Heme Oxygenases
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2007-09-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Peak Exhaled Carbon Monoxide Concentration After Reperfusion Influenced2007

    • Author(s)
      Matsumi M
    • Organizer
      Hyperbilirubinemia Early after Liver Transplantation American Transplant Congress 2007
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2007-05-08
    • Related Report
      2008 Final Research Report
  • [Book] 臓器移植手術の緊急麻酔 B. 肝臓移植について. 緊急麻酔の心得-ここが肝心・おさえどこ!-(池田編)2008

    • Author(s)
      賀来隆治, 松三昌樹, 片山浩
    • Publisher
      克誠堂出版, 東京
    • Related Report
      2008 Final Research Report
  • [Book] 全身性炎症反応における呼気中一酸化炭素(CO)濃度の上昇, (分担)「エンドトキシン研究10 基礎と臨床の最新知見(上西紀夫、小川利久、小玉正智、横地高志、谷徹編)2007

    • Author(s)
      高橋徹、森松博史、松崎孝、清水裕子、井上一由、井戸佳奈、松三昌樹、片山浩、森田潔
    • Publisher
      医学図書出版株式会社、東京
    • Related Report
      2008 Final Research Report
  • [Book] 敗血症性多臓器不全におけるストレス蛋白 : ヘムオキシゲナーゼー1の発現とその意義, (分担)「エンドトキシン研究9自然免疫の最前線(熊沢義雄、小玉正智、横地高志、谷徹編)2006

    • Author(s)
      高橋徹, 上原健司, 清水裕子, 井上一由, 藤井洋泉, 松三昌樹, 片山 浩, 森田潔
    • Publisher
      医学図書出版株式会社、東京
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.okadaimasui.com/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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