Mechanism of information transmission between the irHnune system and the centrai nervous system in chronic

• Project/Area Number: 18591717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: LBUKI Takae Kyoto Prefectural University of Medicine, 医学研究科, 講師 (90232587)
• Research Collaborator: 岡 頼子 京都府立医科大学 ; 槌田 圭一郎 社会保険京都病院 ; 松村 潔 大阪工業大学 ; 小林 茂夫 京都大学
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,010,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 疼痛治療学 / サイトカイン / 情報伝達 / 中枢性痛覚過敏 / 血管内皮細胞 / 痛覚過敏 / 炎症 / 中枢神経系

Research Abstract

末梢性炎症に起因する慢性難治性疼痛発症に、各種炎症性サイトカインが炎症情報を中枢神経系血管内皮細胞に伝達するメカニズムが関与していることが示唆された。また各種炎症性サイトカインの措抗薬の予防薬および治療栗としての可能性が期待される。

Research Products

• [Journal Article] Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS (2007)
  • Author(s): Oka Y, Ibuki T, Matsumura K, Namba, Namba M, Yamazaki Y, Poole S, Tanaka Y, Kobayashi S
  • Journal Title: Neuroscience 14 145 Pages: 530-538
• [Journal Article] Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS (2007)
  • Author(s): Y. Oka, T. Ibuki, K. Matsumura, M. Namba, Y. Yamazaki, S. Poole, Y. Tanaka and S. Kobayashi
  • Journal Title: Neuroscience 145(2) Pages: 530-538
  • Peer Reviewed
• [Journal Article] Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS (2007)
  • Author(s): Y.Oka, T.Ibuki, K.Matsumura, M.Namba, Y.Yamazaki, S.Poole, Y.Tanaka, S.Kobayashi
  • Journal Title: Neuroscience 145(2) Pages: 530-530
• [Presentation] Neuroinflammatory Communication During lnflammatory Hyperalgesia (2009)
  • Author(s): Ibuki T, Oka Y, Tanaka Y, Matsumura K
  • Organizer: Twelfth World Congress on Pain, Glasgow
  • Place of Presentation: England
  • Year and Date: 2009-08-19
• [Presentation] Calcium非依7字位生phospollpaseA2(iPLA2)はカラゲエン誘発性熱性痛覚過敏に関与している (2007)
  • Author(s): 槌田圭一郎、伊吹京秀、松村潔、小林茂夫、田中義文
  • Organizer: 日本麻酔科学会第54回大会
  • Place of Presentation: 札幌
  • Year and Date: 2007-06-01
• [Presentation] Candidate molecule that is involved in the inflammatory signal transmission to the CNS - Pathway to central sensitization Joint lnternational symposium for 3rd spinal cord sciences and 7th society of nursing and health sciences (2007)
  • Author(s): Ibuki T
  • Organizer: maguchi
  • Place of Presentation: Japan
  • Year and Date: 2007-02-10
• [Presentation] Cytokines involved in the transmission of inflarlmatory signal from the periphery to the CNS (2006)
  • Author(s): Ibuki T, Oka Y, Matsumura K, obayashi S, Tanaka Y
  • Organizer: 2006 Annual meeting of the American society of anesthesiologists
  • Place of Presentation: Chicago USA
  • Year and Date: 2006-10-15