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The pain regulatory system in CNS, and ideal anesthetic and pain managements

Research Project

Project/Area Number 18591720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTohoku University

Principal Investigator

MASAKI Eiji  Tohoku University, 大学院歯学研究科, 教授 (40221577)

Co-Investigator(Kenkyū-buntansha) 菊地 博達  埼玉医科大学, 医学部, 教授 (40034029)
Co-Investigator(Renkei-kenkyūsha) KIKUCHI Hirosato  埼玉医科大学, 医学部, 教授 (40034029)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,390,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords術後鎮痛 / 術後回復状態 / デクスメデトミジン / ネオスティグミン / 覚醒時間 / プロポフォール / セボフルレン / 麻酔法 / 患者調節鎮痛法 / 高容量 / 硬膜外麻酔
Research Abstract

これまでまったく疼痛管理とは関係していないとされている薬剤の脊髄、硬膜外投与で緩和されることが明らかとなってきた。このことは脊髄後角レベルに様々な疼痛伝達、抑制機構があることを示している。この機構に作用すると考えられる様々な薬剤を動物実験、臨床研究で用いることにより、手術後に疼痛抑制作用を示すことを明らかとした。このような方法により術後クオリティオブライフが向上することが期待できる。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007 2006

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (11 results)

  • [Journal Article] Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery Anesth2008

    • Author(s)
      Ohtani N, Kida K, Shoji K, Yasui Y, Masaki E
    • Journal Title

      Anesth Analg 107

      Pages: 1871-1874

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery2008

    • Author(s)
      Kida K, Ohtani N, Shoji K, Yasui Y, Masaki E
    • Journal Title

      Eur J Anaesthesiol 25

      Pages: 869-875

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery2008

    • Author(s)
      Kida K, et.al.
    • Journal Title

      Eur J Anaesthesiol 25

      Pages: 869-875

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery2008

    • Author(s)
      Ohtani N
    • Journal Title

      Anesth Analg 107

      Pages: 1871-1874

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane directly excites locus coeruleus neurons of rats2007

    • Author(s)
      Yasui Y, Masaki E, Kato F
    • Journal Title

      Anesthesiology 107

      Pages: 992-1002

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenosine facilitates postoperative analgesic effect of epidural neostigmine after open lower abdominal surgery2007

    • Author(s)
      Kida K, Ohtani N, Shoji K, Yasui Y, Masaki E
    • Journal Title

      Jikeikai Med J 54

      Pages: 133-139

    • NAID

      10024173302

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenosine facilitates postoperative analgesic effect of epidural neostigmine after open lower abdominal surgery.2007

    • Author(s)
      Kida K, et. al.
    • Journal Title

      Jikeikai Med J 54

      Pages: 133-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane directly excites locus coeruleus neurons of rats2007

    • Author(s)
      Yasui Y, et. al.
    • Journal Title

      Anesthesiology 107

      Pages: 992-1002

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 麻酔科関連の新しい薬物とその効果. ランジオロールとエスモロール(超短時間作用性β1遮断薬)(2)抗侵害作用2006

    • Author(s)
      正木英二
    • Journal Title

      麻酔 55

      Pages: 849-855

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Intraoperative infusion of dexmedetomidine decreases postoperative pain scores : A meta-analysis2008

    • Author(s)
      Kida K, Yasui Y, Ohtani N, Kuratani N, Masaki E
    • Organizer
      The 2008 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Dexmedetomidine counteracts the excitatory effect of sevoflurane on LC neurons of the rat2008

    • Author(s)
      Yasui Y, Okamoto Y, Shoji K, Kato F, Masaki E
    • Organizer
      The 2008 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Perioperative infusion of dexmedetomidine at high dose reduces postoperative analgesic requirement2008

    • Author(s)
      Ohtani N, Kida K, Yasui Y, Shoji K, Masaki E
    • Organizer
      The 2008 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Perioperative infusion of dexmedetomidine at high dose reduces postoperative analgesic requirement2008

    • Author(s)
      Ohtani N, et.al.
    • Organizer
      The 2008 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Postoperative pain status after intraoperative infusion of dexmedetomidine and epidural neostigmine2007

    • Author(s)
      Kida K, Ohtani N, Shoji K, Yasui Y, Masaki
    • Organizer
      The 2007 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2007-10-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Postoperative pain status after intraoperative infusion of dexmedetomidine and epidural neostigmine2007

    • Author(s)
      Kida K, el. al.
    • Organizer
      The 2007 annual meeting of American so ciety of Anesthesiologist
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2007-10-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Esmolol Modulates Inhibitory Transmission in the Trigeminal Nociceptive Network of the Rat2007

    • Author(s)
      Yasui Y, Masaki E, Shoji K, Terui T, Kato F
    • Organizer
      The 2007 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2007-10-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Recovery profile of sevoflurane and propofol anesthesia co-administered with dexmedetomidine2007

    • Author(s)
      Ohtani N, Kida K, Yasui Y, Shoji K, Masaki E
    • Organizer
      The 2007 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2007-10-15
    • Related Report
      2008 Final Research Report
  • [Presentation] デスメデトミジン術中使用が術後鎮痛に与える影響2007

    • Author(s)
      木田康太郎、大谷法理、安井豊、庄司和広、正木英二
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌. (J Anesth, 21 : O74-01.2007
    • Year and Date
      2007-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Dexmedetomidine enhances post-operative analgesic effect of epidural neostigmine2006

    • Author(s)
      Kida K, Otani N, Shoji K, Yasui Y, Masaki E
    • Organizer
      The 2006 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2006-10-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Emergence time from sevoflurane and propofol anesthesia co-administered with dexmedetomidine2006

    • Author(s)
      Ohtani N, Kida K, Yasui Y, Shoji K, Masaki E
    • Organizer
      The 2006 annual meeting of American society of Anesthesiologist
    • Place of Presentation
      Chicago,Illinois
    • Year and Date
      2006-10-16
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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