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Basic analysis for the role of Na+/Ca2+ exchanger on ischemic brain damage to establish new brain resusciataion method

Research Project

Project/Area Number 18591724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Medical University

Principal Investigator

UTINO Hiroyuki  Tokyo Medical University, School of Medicine, Assistant Professor (60266476)

Co-Investigator(Kenkyū-buntansha) SHIBAZAKI Hutoshi  Tokyo Metropolitan Organization for Medical Research, The Tokyo Metropolitan Institute of Medical Science, Senior Researcher (90300954)
IWAMOTO Takahiro  Fukuoka University, Faculty of Medicine, Professor (20300973)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsBrain ischemia / Na+ / Ca2+ exchanger / mitochondria / Respiratory Control Ratio / Hippocampal Slice / Calcineurin / immunophilin / CyclosporinA / NA+ / 細胞内Ca2+ / 脳障害
Research Abstract

To investigate the mechanisms of ischemic neuronal cell death, we explored the planned experiments to focus on the relationship between the function of astrocytic Na+/Ca2+ exchanger and intracerebral Ca2+ dynamics, calcineurin/immunophilin cascade, and mitochondrial dysfunction based on Mitochondrial Permeability Transition(MPT) and also investigated the role of Na+/Ca2+ exchanger for the formation of ischemic neuronal cell death. We have used Na+/Ca2+ exchanger KO mouse(NCXKO) for our experiments.
From our pathohistological analysis, NCXKO group did not show any protective effect in mice forebrain ischemia model. NCXKO mice hippocampal slice experiments showed the high intracellular Ca2+ level but not mitochondrial compared to wild group, however, Cyclosporin A also inhibited both the rise of intracellular and intramitochondrial Ca2+ as same as wild group. NCXKO group and wild group showed no significant difference in terms of mitochondrial swelling and calcium retension capacity(CRC) due to Ca2+ overlaod.Respiratory control ratio(RCR) in NCXKO mice showed high oxygen consumption at state 3. From our results, we could speculate the reason why we could not get neuroprotectio is that mice was not homozygous, so gene deletion was not enough to explore the neuroprotection. But from the results of hippocampal slice experiments, we considered that NCX is somehow deleted. Mitochondrial permeability transition was induced in both NCXKO and wild mice and these results suggested that NCX gene deletion does not affect the inhibition of mitochondrial dysfunction. We have speculated the reseason why oxygen consumption was high in NCXKO mice is that Ca2+ extrusion to extracellular space in NCXKO mice need long time compared to wild one, so mitochondria need to produce ATP consuming huge amount of oxygen. From our results, importance of Na+/Ca2+ exchanger was explored.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (55 results)

All 2008 2007 2006

All Journal Article (29 results) (of which Peer Reviewed: 18 results) Presentation (19 results) Book (7 results)

  • [Journal Article] 神経集中治療における脳保護のあり方と薬物療法の現状2008

    • Author(s)
      内野 博之
    • Journal Title

      日集中医誌 15

      Pages: 21-40

    • NAID

      10024840049

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition2007

    • Author(s)
      Morota S, et. al.
    • Journal Title

      J.Neurochem 103

      Pages: 2066-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline2007

    • Author(s)
      Hansson, et. al.
    • Journal Title

      Neurobiol Dis 25

      Pages: 198-205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 【中枢神経の保護】虚血性神経細胞死の分子生物学的機序と薬物療法による脳保護(解説/特集)2007

    • Author(s)
      内野 博之, 諸田 沙織, 平林 剛, 牛島 一男, 柿沼 孝泰, 石井 脩夫, 芝崎 太, 黒田 泰弘
    • Journal Title

      麻酔 56

      Pages: 248-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 虚血性神経細胞障害の基礎的解明と臨床応用への展望-神経細胞死の機序と脳保護-2007

    • Author(s)
      内野 博之, 黒田 泰弘, 平林 剛, 石井 脩夫, 芝崎 太
    • Journal Title

      日臨麻会誌 27

      Pages: 1-26

    • NAID

      10018670347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 集中治療における脳虚血の病態と治療2007

    • Author(s)
      内野 博之
    • Journal Title

      日集中医誌 14

      Pages: 527-550

    • NAID

      10026918357

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition2007

    • Author(s)
      Morota, S, Hansson, MJ, Ishii, N, Kudo, Y, Elmer, E, Uchino, H
    • Journal Title

      J Neurochem 103(5)

      Pages: 2066-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline2007

    • Author(s)
      Mansson, R, Hansson, MJ, Morota, S, Uchino, H, Ekdahl, CT, Elmer, E
    • Journal Title

      Neurobiol Dis 25(1)

      Pages: 198-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Re-evaluation of mitochondrial permeaUility transition as a primary neuroprotective target of minocycline.2007

    • Author(s)
      Hansson, et. al.
    • Journal Title

      Neurobiol Dis 25

      Pages: 198-205

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D in hibition2007

    • Author(s)
      Morota S, et. al.
    • Journal Title

      J.Neurochem 103

      Pages: 2066-2076

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 虚血性神経細胞障害の基礎的解明と臨床応用への展望-神経細胞死の機序と脳保護-2007

    • Author(s)
      内野 博之、黒田 泰弘、平林 剛、石井 脩夫、芝崎 太
    • Journal Title

      日臨麻会誌 27

      Pages: 1-26

    • NAID

      10018670347

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 集中治療における脳虚血の病態と治療2007

    • Author(s)
      内野 博之、牛島 一男、平林 剛、石井 脩夫、黒田 泰弘、芝崎 太
    • Journal Title

      日集中医誌 14

      Pages: 527-550

    • NAID

      10026918357

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Neuroprotective Compound FR901459 with Dual Inhibition of Calcineurin and Cyclophilins2006

    • Author(s)
      Uchino H, Morota S, Takahashi T, Chen Li, Ikeda Y, Kudo Y, Ishii N, Siesjo BK and Shibasaki F
    • Journal Title

      Acta Neurochir Sppl 96

      Pages: 157-162

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Search the Novel Genemakers for Traumatic Brain Injury by Time Differential Microarray Analysis2006

    • Author(s)
      Yu-ichiro Ishikawa, Hiroyuki Uchino, , Saori Morota, Chen Li Toshiaki Takahashi, Yukio Ikeda Nagao Ishii and Futoshi Shibasaki
    • Journal Title

      Acta Neurochir Sppl 96

      Pages: 163-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of Cyclosporin A on Immediate Early Gene in rat global ischemia and its neuroprotection2006

    • Author(s)
      Tatsuo Yamaguchi, Kazuto Miyata, Futoshi Shibasaki, Atushi Isshiki Hiroyuki Uchino
    • Journal Title

      Journal of Pharmacological Science 100

      Pages: 73-81

    • NAID

      10018241202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 脳低温療法とNeuloscience Critical Care Brain Hypothermia and Neuroscience Critical Care2006

    • Author(s)
      池田 幸穂, 村上 守, 伊澤 仁之, 大野 晋, 西岡 宏, 中島 智, 内野 博之, 原岡 裏
    • Journal Title

      東京医科大学雑誌 64

      Pages: 557-564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 脳障害のメカニズム2006

    • Author(s)
      内野 博之, 諸田 沙織, Chen Li, 高橋 俊明, 工藤 佳久, 石井 脩夫, 芝崎 太
    • Journal Title

      蘇生 25

      Pages: 1-11

    • NAID

      10017417823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 虚血性神経細胞死のメカニズム2006

    • Author(s)
      内野 博之, 諸田 沙織, 牛島 一男, Chen Li, 高橋 俊明, 池田 幸穂, 工藤 佳久, 石井 脩夫, 芝崎 太
    • Journal Title

      蘇生 25

      Pages: 88-99

    • NAID

      10017644555

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 蘇生後脳症における脳循環代謝2006

    • Author(s)
      黒田 泰弘, 山下 進, 中村 丈洋, 河北 賢哉, 西由 佳宏, 河井 信行, 内野 博之
    • Journal Title

      日救急医会誌(JJAAM) 17

      Pages: 167-176

    • NAID

      10018811070

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] マイクロダイアリシスによる脳代謝モニタリング2006

    • Author(s)
      黒田 泰弘, 山下 進, 中村 丈洋, 阿部 祐子, 河北 賢哉, 河井 信行, 内野 博之
    • Journal Title

      ICUとCCU 30

      Pages: 269-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Novel Neuroprotective Compound FR901459 with Dual Inhibition of Calcineurin and Cyclophilins2006

    • Author(s)
      Uchino, H, Morota, S, Takahashi, T, Chen, Li, Ikeda, Y, Kudo, Y, Ishii, N, Siesjo, BK, Shibasaki, F
    • Journal Title

      Acta Neurochir Sppl

      Pages: 157-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Search the Novel Genemakers for Traumatic Brain Injury by Time Differential Microarray Analysis2006

    • Author(s)
      Yu-ichiro, Ishikawa, Hiroyuki, Uchino, Saori, Morota, Chen, Li, Toshiaki, Takahashi, Yukio, Ikeda, Nagao, Ishii, Futoshi, Shibasaki
    • Journal Title

      Acta Neurochir Sppl

      Pages: 163-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of Cyclosporin A on Immediate Early Gene in rat global ischemia and its neuroprotection2006

    • Author(s)
      Tatsuo, Yamaguchi, Kazuto, Miyata, Futoshi, Shibasaki, Atushi, Isshiki, Hiroyuki, Uchino
    • Journal Title

      Journal of Pharmacological Science 100(1)

      Pages: 73-81

    • NAID

      10018241202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Novel Neuroprotective Compound FR901459 with Dual Inhibition of Calcineurin and Cyclophilins2006

    • Author(s)
      Uchino H et al.
    • Journal Title

      Acta Neurochir Sppl

      Pages: 157-162

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 脳障害のメカニズム2006

    • Author(s)
      内野 博之
    • Journal Title

      蘇生 25(1)

      Pages: 1-11

    • NAID

      10017417823

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 虚血性神経細胞死のメカニズム2006

    • Author(s)
      内野 博之
    • Journal Title

      蘇生 25(2)

      Pages: 88-99

    • NAID

      10017644555

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 蘇生後脳症における脳循環代謝2006

    • Author(s)
      黒田泰弘 等
    • Journal Title

      日救急医会誌(JJAAM) 17

      Pages: 167-176

    • Related Report
      2006 Annual Research Report
  • [Journal Article] マイクロダイアリシスによる脳代謝モニタリング2006

    • Author(s)
      黒田泰弘 等
    • Journal Title

      ICUとCCU 30(4)

      Pages: 269-278

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of Cyclosporin A on Immediate Early Gene in rat global Ischemia and its neuroprotection2006

    • Author(s)
      Tatsuo Yamaguchi et al.
    • Journal Title

      Journal of Pharmacological Science 100(1)

      Pages: 73-81

    • Related Report
      2006 Annual Research Report
  • [Presentation] 神経麻酔集中治療における脳障害のメカニズム解明と脳保護法確立のため戦略2007

    • Author(s)
      内野 博之
    • Organizer
      日本臨床麻酔学会第27回大会
    • Place of Presentation
      東京
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 脳低温療法中の尿中フリーラジカルについて2007

    • Author(s)
      池田 一美, 池田 寿昭, 上野 琢哉, 横山 智仁, 須田 慎吾, 内野 博之
    • Organizer
      第21回日本神経救急学会
    • Place of Presentation
      京都
    • Year and Date
      2007-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Cyclopsorin A prevent mitochondrial permeability transition similarly in both brain and spinal cord2007

    • Author(s)
      Saori Morota, Magnus Hasson, Yoshihisa Kudo, Eskil Elmer, Nagao Ishii, Hiroyuki Uchino
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism&Function
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cyclopsorin A prevent mitochondrial permeability transition similarly in both brain and spinal cord2007

    • Author(s)
      Saori Morota, Magims Hasson, Yoshihisa Kudo, Eskil Elme, Nagao Isllii, Hiroyuki Uchino
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Educational course 3:Anesthesia in stroke experiments Are general and reginal anesthetics neuroprotective2007

    • Author(s)
      Hiroyuki Uchino
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism&Function
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Educational course 3 : Anesthesia in stroke experiments Are general and reginal anesthetics neuroprotective?2007

    • Author(s)
      Hiroyuki, Uchino
    • Organizer
      The 23rd International Symposium on Cerebral blood flow and Metabolism & Function
    • Place of Presentation
      Osaka
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Educational course 3:Anesthesia in stroke experiments Are general and reginal anesthetics neuroprotective?2007

    • Author(s)
      Hiroyuki Uchino
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳虚血侵襲と脳保護2007

    • Author(s)
      内野 博之
    • Organizer
      香川侵襲と生体反応研究会
    • Place of Presentation
      香川
    • Year and Date
      2007-01-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蘇生後の脳低温療法低酸素性脳症に対する脳低温療法について全身冷却法と頭部冷却法の比較2007

    • Author(s)
      池田 一美, 池田 寿昭, 黒木 雄一, 横山 智仁, 吉川 和幸, 内野 博之
    • Organizer
      第34回日本集中治療医学会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脳と脊髄のCa2+負荷誘発性MRT解析に基づくミトコンドリア機能の比較2007

    • Author(s)
      内野 博之, 石井 脩夫
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 蘇生後の脳低温療法低酸素性脳症に対する脳低温療法について全身冷却法と頭部冷却法の比較2007

    • Author(s)
      池田 一美, 池田 寿昭, 黒木 雄一, 横山 智仁, 吉川 和幸, 内野 博之
    • Organizer
      第10回日本脳低温療法学会
    • Place of Presentation
      山口
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] シンポジウム「脳虚血の治療と麻酔」虚血性脳障害におけるミトコンドリア機能不全の役割と麻酔薬による脳保護の可能性2007

    • Author(s)
      内野 博之, 芝崎 太, 石井 脩夫
    • Organizer
      日本蘇生学会第25回大会
    • Place of Presentation
      岡山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms of cerebral nerve injuries during intensive care and possible drug-mediated protection of brain2006

    • Author(s)
      Hiroyuki, Uchino, Go, Hirabayashi, Takayasu, Kakinuma, Tomoyoshi, Johko, Futoshi, Shibasaki, Nagao, Ishii
    • Organizer
      2nd joint symposium of Japan-Korea-China Neuroanesthesia 140
    • Place of Presentation
      Osaka
    • Year and Date
      2006-04-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms of cerebral nerve injuries during intensive care and possible drug-mediated protection of brain2006

    • Author(s)
      Hiroyuki Uchino, Go Hirabayashi, Takayasu Kakinuma, Tomoyoshi Johko, Futoshi Shibasaki, Nagao Ishii
    • Organizer
      第2回日中韓神経麻酔ジョイントシンポジウム
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シンポジウム「心臓手術における脳障害とその予防」周術期の脳障害マーカーとその制御2006

    • Author(s)
      内野 博之
    • Organizer
      日本麻酔科学会第53回学術集会
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms of cerebral nerve injuries during intensive care and importance of calcineurin/immunophilin signal transduction cascade2006

    • Author(s)
      Hiroyuki Uchino, Nagao Ishii, Yukio Ikeda
    • Organizer
      日本脳低温療法学会第9回大会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脳低温療法における尿中-ヒドロキシデオキシグアニジン(8-OHdG)の変化について-全身冷却法と頭部冷却法の比較-2006

    • Author(s)
      池田 一美, 池田 寿昭, 黒木 雄一, 横山 智仁, 吉川 和幸, 石井 脩夫, 内野 博之
    • Organizer
      第34回日本救急医学会総会、学術集会
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脳および脊髄ミトコンドリアにおけるカルシウム誘発性ミトコンドリア膜透過性充進の比較2006

    • Author(s)
      諸田 沙織, Magnus J.Hansson, 内野 博之, Eskil Elmer, 工藤 佳久, 石井 脩夫
    • Organizer
      日本蘇生学会第25回大会
    • Place of Presentation
      浜松
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms of cerebral nerve injuries during intensive care and importance of calcineurin/immunophilin signal transduction cascade symposium f Imuunophilins and Neuroprotection2006

    • Author(s)
      Hiroyuki, Uchino, Nagao, Ishii, Yukio, Ikeda
    • Organizer
      9th congress of Japanese Society of Brain Hypothermia
    • Place of Presentation
      tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 救急、集中治療ガイドライン2007

    • Author(s)
      内野 博之
    • Publisher
      総合医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 脳神経外科麻酔ミラー麻酔科学2007

    • Author(s)
      内野 博之
    • Publisher
      メディカルサイエンスインターナショナル
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 救急・集中治療ガイドライン2007

    • Author(s)
      内野 博之
    • Publisher
      総合医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 救急、集中治療ガイドライン18(5-6)2006

    • Author(s)
      内野 博之, 池田 幸穂, 黒田 泰弘
    • Publisher
      総合医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 脳保護のストラテジーJSAリフレッシャーコース2006

    • Author(s)
      内野 博之
    • Publisher
      メディカルサイエンスインターナショナル
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 頭蓋内の生理学と頭蓋内圧充進神経救急集中治療ガイドライン2006

    • Author(s)
      内野 博之
    • Publisher
      メディカルサイエンスインターナショナル
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 救急・集中治療ガイドライン-最新の診療方針-2006

    • Author(s)
      岡元 和文 (編集)
    • Total Pages
      810
    • Publisher
      総合医学社
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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